Predicting the development of normal tension glaucoma and related risk factors in normal tension glaucoma suspects

Abstract This study investigated the predicted risk factors for the development of normal-tension glaucoma (NTG) in NTG suspects. A total of 684 eyes of 379 NTG suspects who were followed-up for at least 5 years were included in the study. NTG suspects were those having (1) intraocular pressure with...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hae-Young Lopilly Park, Da Young Shin, Soo Ji Jeon, Yong-Chan Kim, Younhea Jung, Eun Kyoung Kim, Hye-Young Shin, Kyoung In Jung, Jin A. Choi, Na Young Lee, Seung Woo Hong, Chan Kee Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e8434c08287c47ce9b9cbf1e4c54a08f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e8434c08287c47ce9b9cbf1e4c54a08f
record_format	dspace
spelling	oai:doaj.org-article:e8434c08287c47ce9b9cbf1e4c54a08f2021-12-02T17:08:36ZPredicting the development of normal tension glaucoma and related risk factors in normal tension glaucoma suspects10.1038/s41598-021-95984-72045-2322https://doaj.org/article/e8434c08287c47ce9b9cbf1e4c54a08f2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95984-7https://doaj.org/toc/2045-2322Abstract This study investigated the predicted risk factors for the development of normal-tension glaucoma (NTG) in NTG suspects. A total of 684 eyes of 379 NTG suspects who were followed-up for at least 5 years were included in the study. NTG suspects were those having (1) intraocular pressure within normal range, (2) suspicious optic disc (neuroretinal rim thinning) or enlarged cup-to-disc ratio (≥ 0.6), but without definite localized retinal nerve fiber layer (RNFL) defects on red-free disc/fundus photographs, and (3) normal visual field (VF). Demographic, systemic, and ocular characteristics were determined at the time of the first visit via detailed history-taking and examination of past medical records. Various ocular parameters were assess using spectral-domain optical coherence tomography and Heidelberg retinal tomography. Conversion to NTG was defined either by the presence of a new localized RNFL defect at the superotemporal or inferotemporal region on disc/fundus red-free photographs, or presence of a glaucomatous VF defect on pattern standard deviation plots on two consecutive tests. Hazard ratios were calculated with the Cox proportional hazard model. In total, 86 (12.6%) of the 684 NTG suspects converted to NTG during the follow-up period of 69.39 ± 7.77 months. Significant (P < 0.05, Cox regression) risk factors included medication for systemic hypertension, longer axial length, worse baseline VF parameters, thinner baseline peripapillary RNFL, greater disc torsion, and lamina cribrosa (LC) thickness < 180.5 μm (using a cut-off value obtained by regression analysis). Significant (P < 0.05, Cox regression) risk factors in the non-myopic NTG suspects included medication for systemic hypertension and a LC thinner than the cut-off value. Significant (P < 0.05, Cox regression) risk factors in the myopic NTG suspects included greater disc torsion. The results indicated that 12.6% of NTG suspects converted to NTG during the 5–6-year follow-up period. NTG suspects taking medication for systemic hypertension, disc torsion of the optic disc in the inferotemporal direction, and thinner LC of the optic nerve head at baseline were at greater risk of NTG conversion. Related baseline risk factors were different between myopic and non-myopic NTG suspects.Hae-Young Lopilly ParkDa Young ShinSoo Ji JeonYong-Chan KimYounhea JungEun Kyoung KimHye-Young ShinKyoung In JungJin A. ChoiNa Young LeeSeung Woo HongChan Kee ParkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hae-Young Lopilly Park Da Young Shin Soo Ji Jeon Yong-Chan Kim Younhea Jung Eun Kyoung Kim Hye-Young Shin Kyoung In Jung Jin A. Choi Na Young Lee Seung Woo Hong Chan Kee Park Predicting the development of normal tension glaucoma and related risk factors in normal tension glaucoma suspects
description	Abstract This study investigated the predicted risk factors for the development of normal-tension glaucoma (NTG) in NTG suspects. A total of 684 eyes of 379 NTG suspects who were followed-up for at least 5 years were included in the study. NTG suspects were those having (1) intraocular pressure within normal range, (2) suspicious optic disc (neuroretinal rim thinning) or enlarged cup-to-disc ratio (≥ 0.6), but without definite localized retinal nerve fiber layer (RNFL) defects on red-free disc/fundus photographs, and (3) normal visual field (VF). Demographic, systemic, and ocular characteristics were determined at the time of the first visit via detailed history-taking and examination of past medical records. Various ocular parameters were assess using spectral-domain optical coherence tomography and Heidelberg retinal tomography. Conversion to NTG was defined either by the presence of a new localized RNFL defect at the superotemporal or inferotemporal region on disc/fundus red-free photographs, or presence of a glaucomatous VF defect on pattern standard deviation plots on two consecutive tests. Hazard ratios were calculated with the Cox proportional hazard model. In total, 86 (12.6%) of the 684 NTG suspects converted to NTG during the follow-up period of 69.39 ± 7.77 months. Significant (P < 0.05, Cox regression) risk factors included medication for systemic hypertension, longer axial length, worse baseline VF parameters, thinner baseline peripapillary RNFL, greater disc torsion, and lamina cribrosa (LC) thickness < 180.5 μm (using a cut-off value obtained by regression analysis). Significant (P < 0.05, Cox regression) risk factors in the non-myopic NTG suspects included medication for systemic hypertension and a LC thinner than the cut-off value. Significant (P < 0.05, Cox regression) risk factors in the myopic NTG suspects included greater disc torsion. The results indicated that 12.6% of NTG suspects converted to NTG during the 5–6-year follow-up period. NTG suspects taking medication for systemic hypertension, disc torsion of the optic disc in the inferotemporal direction, and thinner LC of the optic nerve head at baseline were at greater risk of NTG conversion. Related baseline risk factors were different between myopic and non-myopic NTG suspects.
format	article
author	Hae-Young Lopilly Park Da Young Shin Soo Ji Jeon Yong-Chan Kim Younhea Jung Eun Kyoung Kim Hye-Young Shin Kyoung In Jung Jin A. Choi Na Young Lee Seung Woo Hong Chan Kee Park
author_facet	Hae-Young Lopilly Park Da Young Shin Soo Ji Jeon Yong-Chan Kim Younhea Jung Eun Kyoung Kim Hye-Young Shin Kyoung In Jung Jin A. Choi Na Young Lee Seung Woo Hong Chan Kee Park
author_sort	Hae-Young Lopilly Park
title	Predicting the development of normal tension glaucoma and related risk factors in normal tension glaucoma suspects
title_short	Predicting the development of normal tension glaucoma and related risk factors in normal tension glaucoma suspects
title_full	Predicting the development of normal tension glaucoma and related risk factors in normal tension glaucoma suspects
title_fullStr	Predicting the development of normal tension glaucoma and related risk factors in normal tension glaucoma suspects
title_full_unstemmed	Predicting the development of normal tension glaucoma and related risk factors in normal tension glaucoma suspects
title_sort	predicting the development of normal tension glaucoma and related risk factors in normal tension glaucoma suspects
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e8434c08287c47ce9b9cbf1e4c54a08f
work_keys_str_mv	AT haeyounglopillypark predictingthedevelopmentofnormaltensionglaucomaandrelatedriskfactorsinnormaltensionglaucomasuspects AT dayoungshin predictingthedevelopmentofnormaltensionglaucomaandrelatedriskfactorsinnormaltensionglaucomasuspects AT soojijeon predictingthedevelopmentofnormaltensionglaucomaandrelatedriskfactorsinnormaltensionglaucomasuspects AT yongchankim predictingthedevelopmentofnormaltensionglaucomaandrelatedriskfactorsinnormaltensionglaucomasuspects AT younheajung predictingthedevelopmentofnormaltensionglaucomaandrelatedriskfactorsinnormaltensionglaucomasuspects AT eunkyoungkim predictingthedevelopmentofnormaltensionglaucomaandrelatedriskfactorsinnormaltensionglaucomasuspects AT hyeyoungshin predictingthedevelopmentofnormaltensionglaucomaandrelatedriskfactorsinnormaltensionglaucomasuspects AT kyounginjung predictingthedevelopmentofnormaltensionglaucomaandrelatedriskfactorsinnormaltensionglaucomasuspects AT jinachoi predictingthedevelopmentofnormaltensionglaucomaandrelatedriskfactorsinnormaltensionglaucomasuspects AT nayounglee predictingthedevelopmentofnormaltensionglaucomaandrelatedriskfactorsinnormaltensionglaucomasuspects AT seungwoohong predictingthedevelopmentofnormaltensionglaucomaandrelatedriskfactorsinnormaltensionglaucomasuspects AT chankeepark predictingthedevelopmentofnormaltensionglaucomaandrelatedriskfactorsinnormaltensionglaucomasuspects
_version_	1718381589886402560

Predicting the development of normal tension glaucoma and related risk factors in normal tension glaucoma suspects

Ejemplares similares