Oxidized Albumin and Cartilage Acidic Protein-1 as Blood Biomarkers to Predict Ischemic Stroke Outcomes

Background: There is high demand for blood biomarkers that reflect the therapeutic response or predict the outcomes of patients with acute ischemic stroke (AIS); however, few biomarkers have been evidentially verified to date. This study evaluated two proteins, oxidized albumin (OxHSA) and cartilage...

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Autores principales:	Takahiro Kuwashiro, Kazuhiro Tanabe, Chihiro Hayashi, Tadataka Mizoguchi, Kota Mori, Juro Jinnouchi, Masahiro Yasaka, Yasushi Okada
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	acute ischemic stroke cartilage acidic protein-1 oxidative stress oxidized albumin mass spectrometry LC-MS/MS Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/e8475af34b3a4606a9e01335ff366cc8
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spelling	oai:doaj.org-article:e8475af34b3a4606a9e01335ff366cc82021-12-01T20:31:59ZOxidized Albumin and Cartilage Acidic Protein-1 as Blood Biomarkers to Predict Ischemic Stroke Outcomes1664-229510.3389/fneur.2021.686555https://doaj.org/article/e8475af34b3a4606a9e01335ff366cc82021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fneur.2021.686555/fullhttps://doaj.org/toc/1664-2295Background: There is high demand for blood biomarkers that reflect the therapeutic response or predict the outcomes of patients with acute ischemic stroke (AIS); however, few biomarkers have been evidentially verified to date. This study evaluated two proteins, oxidized albumin (OxHSA) and cartilage acidic protein-1 (CRTAC1), as potential prognostic markers of AIS.Methods: The ratio of OxHSA to normal albumin (%OxHSA) and the level of CRTAC1 in the sera of 74 AIS patients were analyzed on admission (day 0), and at 1 and 7 days after admission. AIS patients were divided into two groups according to their modified Rankin Scale (mRS) at 3 months after discharge: the low-mRS (mRS < 2) group included 48 patients and the high-mRS (mRS ≥ 2) group included 26 patients. The differences in %OxHSA and CRTAC1 between the two groups on days 0, 1, and 7 were evaluated.Results: The mean %OxHSA values of the high-mRS group on days 0, 1, and 7 were significantly higher than those of the low-mRS group (p < 0.05). The CRTAC1 levels continuously increased from day 0 to day 7, and those of the high-mRS group were significantly higher than those of the low-mRS group on day 7 (p < 0.05).Conclusions: These results suggest that higher %OxHSA and CRTAC1 are associated with poor outcomes in AIS patients. An index that combines %OxHSA and CRTAC1 can accurately predict the outcomes of AIS patients.Takahiro KuwashiroKazuhiro TanabeKazuhiro TanabeChihiro HayashiTadataka MizoguchiKota MoriJuro JinnouchiMasahiro YasakaYasushi OkadaFrontiers Media S.A.articleacute ischemic strokecartilage acidic protein-1oxidative stressoxidized albuminmass spectrometryLC-MS/MSNeurology. Diseases of the nervous systemRC346-429ENFrontiers in Neurology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	acute ischemic stroke cartilage acidic protein-1 oxidative stress oxidized albumin mass spectrometry LC-MS/MS Neurology. Diseases of the nervous system RC346-429
spellingShingle	acute ischemic stroke cartilage acidic protein-1 oxidative stress oxidized albumin mass spectrometry LC-MS/MS Neurology. Diseases of the nervous system RC346-429 Takahiro Kuwashiro Kazuhiro Tanabe Kazuhiro Tanabe Chihiro Hayashi Tadataka Mizoguchi Kota Mori Juro Jinnouchi Masahiro Yasaka Yasushi Okada Oxidized Albumin and Cartilage Acidic Protein-1 as Blood Biomarkers to Predict Ischemic Stroke Outcomes
description	Background: There is high demand for blood biomarkers that reflect the therapeutic response or predict the outcomes of patients with acute ischemic stroke (AIS); however, few biomarkers have been evidentially verified to date. This study evaluated two proteins, oxidized albumin (OxHSA) and cartilage acidic protein-1 (CRTAC1), as potential prognostic markers of AIS.Methods: The ratio of OxHSA to normal albumin (%OxHSA) and the level of CRTAC1 in the sera of 74 AIS patients were analyzed on admission (day 0), and at 1 and 7 days after admission. AIS patients were divided into two groups according to their modified Rankin Scale (mRS) at 3 months after discharge: the low-mRS (mRS < 2) group included 48 patients and the high-mRS (mRS ≥ 2) group included 26 patients. The differences in %OxHSA and CRTAC1 between the two groups on days 0, 1, and 7 were evaluated.Results: The mean %OxHSA values of the high-mRS group on days 0, 1, and 7 were significantly higher than those of the low-mRS group (p < 0.05). The CRTAC1 levels continuously increased from day 0 to day 7, and those of the high-mRS group were significantly higher than those of the low-mRS group on day 7 (p < 0.05).Conclusions: These results suggest that higher %OxHSA and CRTAC1 are associated with poor outcomes in AIS patients. An index that combines %OxHSA and CRTAC1 can accurately predict the outcomes of AIS patients.
format	article
author	Takahiro Kuwashiro Kazuhiro Tanabe Kazuhiro Tanabe Chihiro Hayashi Tadataka Mizoguchi Kota Mori Juro Jinnouchi Masahiro Yasaka Yasushi Okada
author_facet	Takahiro Kuwashiro Kazuhiro Tanabe Kazuhiro Tanabe Chihiro Hayashi Tadataka Mizoguchi Kota Mori Juro Jinnouchi Masahiro Yasaka Yasushi Okada
author_sort	Takahiro Kuwashiro
title	Oxidized Albumin and Cartilage Acidic Protein-1 as Blood Biomarkers to Predict Ischemic Stroke Outcomes
title_short	Oxidized Albumin and Cartilage Acidic Protein-1 as Blood Biomarkers to Predict Ischemic Stroke Outcomes
title_full	Oxidized Albumin and Cartilage Acidic Protein-1 as Blood Biomarkers to Predict Ischemic Stroke Outcomes
title_fullStr	Oxidized Albumin and Cartilage Acidic Protein-1 as Blood Biomarkers to Predict Ischemic Stroke Outcomes
title_full_unstemmed	Oxidized Albumin and Cartilage Acidic Protein-1 as Blood Biomarkers to Predict Ischemic Stroke Outcomes
title_sort	oxidized albumin and cartilage acidic protein-1 as blood biomarkers to predict ischemic stroke outcomes
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/e8475af34b3a4606a9e01335ff366cc8
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Oxidized Albumin and Cartilage Acidic Protein-1 as Blood Biomarkers to Predict Ischemic Stroke Outcomes

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