B cell intrinsic expression of IFNλ receptor suppresses the acute humoral immune response to experimental blood-stage malaria

Antibodies play a critical protective role in the host response to blood-stage malaria infection. The role of cytokines in shaping the antibody response to blood-stage malaria is unclear. Interferon lambda (IFNλ), a type III interferon, is a cytokine produced early during blood-stage malaria infecti...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	William O. Hahn, Marion Pepper, W. Conrad Liles
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2020
Materias:	malaria plasmodium type iii interferon interferon-λ humoral immune response Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/e84b43c0af7148f3803c226d2380e90a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e84b43c0af7148f3803c226d2380e90a
record_format	dspace
spelling	oai:doaj.org-article:e84b43c0af7148f3803c226d2380e90a2021-11-17T14:21:58ZB cell intrinsic expression of IFNλ receptor suppresses the acute humoral immune response to experimental blood-stage malaria2150-55942150-560810.1080/21505594.2020.1768329https://doaj.org/article/e84b43c0af7148f3803c226d2380e90a2020-12-01T00:00:00Zhttp://dx.doi.org/10.1080/21505594.2020.1768329https://doaj.org/toc/2150-5594https://doaj.org/toc/2150-5608Antibodies play a critical protective role in the host response to blood-stage malaria infection. The role of cytokines in shaping the antibody response to blood-stage malaria is unclear. Interferon lambda (IFNλ), a type III interferon, is a cytokine produced early during blood-stage malaria infection that has an unknown physiological role during malaria infection. We demonstrate that B cell-intrinsic IFNλ signals suppress the acute antibody response, acute plasmablast response, and impede acute parasite clearance during a primary blood-stage malaria infection. Our findings demonstrate a previously unappreciated role for B cell intrinsic IFNλ-signaling in the initiation of the humoral immune response in the host response to experimental malaria.William O. HahnMarion PepperW. Conrad LilesTaylor & Francis Grouparticlemalariaplasmodiumtype iii interferoninterferon-λhumoral immune responseInfectious and parasitic diseasesRC109-216ENVirulence, Vol 11, Iss 1, Pp 594-606 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	malaria plasmodium type iii interferon interferon-λ humoral immune response Infectious and parasitic diseases RC109-216
spellingShingle	malaria plasmodium type iii interferon interferon-λ humoral immune response Infectious and parasitic diseases RC109-216 William O. Hahn Marion Pepper W. Conrad Liles B cell intrinsic expression of IFNλ receptor suppresses the acute humoral immune response to experimental blood-stage malaria
description	Antibodies play a critical protective role in the host response to blood-stage malaria infection. The role of cytokines in shaping the antibody response to blood-stage malaria is unclear. Interferon lambda (IFNλ), a type III interferon, is a cytokine produced early during blood-stage malaria infection that has an unknown physiological role during malaria infection. We demonstrate that B cell-intrinsic IFNλ signals suppress the acute antibody response, acute plasmablast response, and impede acute parasite clearance during a primary blood-stage malaria infection. Our findings demonstrate a previously unappreciated role for B cell intrinsic IFNλ-signaling in the initiation of the humoral immune response in the host response to experimental malaria.
format	article
author	William O. Hahn Marion Pepper W. Conrad Liles
author_facet	William O. Hahn Marion Pepper W. Conrad Liles
author_sort	William O. Hahn
title	B cell intrinsic expression of IFNλ receptor suppresses the acute humoral immune response to experimental blood-stage malaria
title_short	B cell intrinsic expression of IFNλ receptor suppresses the acute humoral immune response to experimental blood-stage malaria
title_full	B cell intrinsic expression of IFNλ receptor suppresses the acute humoral immune response to experimental blood-stage malaria
title_fullStr	B cell intrinsic expression of IFNλ receptor suppresses the acute humoral immune response to experimental blood-stage malaria
title_full_unstemmed	B cell intrinsic expression of IFNλ receptor suppresses the acute humoral immune response to experimental blood-stage malaria
title_sort	b cell intrinsic expression of ifnλ receptor suppresses the acute humoral immune response to experimental blood-stage malaria
publisher	Taylor & Francis Group
publishDate	2020
url	https://doaj.org/article/e84b43c0af7148f3803c226d2380e90a
work_keys_str_mv	AT williamohahn bcellintrinsicexpressionofifnlreceptorsuppressestheacutehumoralimmuneresponsetoexperimentalbloodstagemalaria AT marionpepper bcellintrinsicexpressionofifnlreceptorsuppressestheacutehumoralimmuneresponsetoexperimentalbloodstagemalaria AT wconradliles bcellintrinsicexpressionofifnlreceptorsuppressestheacutehumoralimmuneresponsetoexperimentalbloodstagemalaria
_version_	1718425517591363584

B cell intrinsic expression of IFNλ receptor suppresses the acute humoral immune response to experimental blood-stage malaria

Ejemplares similares