Physical and digital phantoms for validating tractography and assessing artifacts

Fiber tractography is widely used to non-invasively map white-matter bundles in vivo using diffusion-weighted magnetic resonance imaging (dMRI). As it is the case for all scientific methods, proper validation is a key prerequisite for the successful application of fiber tractography, be it in the ar...

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Autores principales:	Ivana Drobnjak, Peter Neher, Cyril Poupon, Tabinda Sarwar
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/e84cd92b1b2a40b59086095e64a2e756
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spelling	oai:doaj.org-article:e84cd92b1b2a40b59086095e64a2e7562021-11-14T04:30:57ZPhysical and digital phantoms for validating tractography and assessing artifacts1095-957210.1016/j.neuroimage.2021.118704https://doaj.org/article/e84cd92b1b2a40b59086095e64a2e7562021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1053811921009769https://doaj.org/toc/1095-9572Fiber tractography is widely used to non-invasively map white-matter bundles in vivo using diffusion-weighted magnetic resonance imaging (dMRI). As it is the case for all scientific methods, proper validation is a key prerequisite for the successful application of fiber tractography, be it in the area of basic neuroscience or in a clinical setting. It is well-known that the indirect estimation of the fiber tracts from the local diffusion signal is highly ambiguous and extremely challenging. Furthermore, the validation of fiber tractography methods is hampered by the lack of a real ground truth, which is caused by the extremely complex brain microstructure that is not directly observable non-invasively and that is the basis of the huge network of long-range fiber connections in the brain that are the actual target of fiber tractography methods. As a substitute for in vivo data with a real ground truth that could be used for validation, a widely and successfully employed approach is the use of synthetic phantoms. In this work, we are providing an overview of the state-of-the-art in the area of physical and digital phantoms, answering the following guiding questions: “What are dMRI phantoms and what are they good for?”, “What would the ideal phantom for validation fiber tractography look like?” and “What phantoms, phantom datasets and tools used for their creation are available to the research community?”. We will further discuss the limitations and opportunities that come with the use of dMRI phantoms, and what future direction this field of research might take.Ivana DrobnjakPeter NeherCyril PouponTabinda SarwarElsevierarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENNeuroImage, Vol 245, Iss , Pp 118704- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Ivana Drobnjak Peter Neher Cyril Poupon Tabinda Sarwar Physical and digital phantoms for validating tractography and assessing artifacts
description	Fiber tractography is widely used to non-invasively map white-matter bundles in vivo using diffusion-weighted magnetic resonance imaging (dMRI). As it is the case for all scientific methods, proper validation is a key prerequisite for the successful application of fiber tractography, be it in the area of basic neuroscience or in a clinical setting. It is well-known that the indirect estimation of the fiber tracts from the local diffusion signal is highly ambiguous and extremely challenging. Furthermore, the validation of fiber tractography methods is hampered by the lack of a real ground truth, which is caused by the extremely complex brain microstructure that is not directly observable non-invasively and that is the basis of the huge network of long-range fiber connections in the brain that are the actual target of fiber tractography methods. As a substitute for in vivo data with a real ground truth that could be used for validation, a widely and successfully employed approach is the use of synthetic phantoms. In this work, we are providing an overview of the state-of-the-art in the area of physical and digital phantoms, answering the following guiding questions: “What are dMRI phantoms and what are they good for?”, “What would the ideal phantom for validation fiber tractography look like?” and “What phantoms, phantom datasets and tools used for their creation are available to the research community?”. We will further discuss the limitations and opportunities that come with the use of dMRI phantoms, and what future direction this field of research might take.
format	article
author	Ivana Drobnjak Peter Neher Cyril Poupon Tabinda Sarwar
author_facet	Ivana Drobnjak Peter Neher Cyril Poupon Tabinda Sarwar
author_sort	Ivana Drobnjak
title	Physical and digital phantoms for validating tractography and assessing artifacts
title_short	Physical and digital phantoms for validating tractography and assessing artifacts
title_full	Physical and digital phantoms for validating tractography and assessing artifacts
title_fullStr	Physical and digital phantoms for validating tractography and assessing artifacts
title_full_unstemmed	Physical and digital phantoms for validating tractography and assessing artifacts
title_sort	physical and digital phantoms for validating tractography and assessing artifacts
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/e84cd92b1b2a40b59086095e64a2e756
work_keys_str_mv	AT ivanadrobnjak physicalanddigitalphantomsforvalidatingtractographyandassessingartifacts AT peterneher physicalanddigitalphantomsforvalidatingtractographyandassessingartifacts AT cyrilpoupon physicalanddigitalphantomsforvalidatingtractographyandassessingartifacts AT tabindasarwar physicalanddigitalphantomsforvalidatingtractographyandassessingartifacts
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Physical and digital phantoms for validating tractography and assessing artifacts

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