Association Between Colchicine Treatment and Clinical Outcomes in Patients with Coronary Artery Disease: Systematic Review and Meta-analysis

Background: The authors examined the association between colchicine treatment and clinical outcomes in patients with coronary artery disease. Methods: They performed a meta-analysis of randomised controlled trials (RCTs) involving patients with coronary artery disease receiving add-on colchicine to...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Francesco Condello, Matteo Sturla, Bernhard Reimers, Gaetano Liccardo, Giulio G Stefanini, Gianluigi Condorelli, Giuseppe Ferrante
Formato:	article
Lenguaje:	EN
Publicado:	Radcliffe Medical Media 2021
Materias:	Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/e850f9fdd86a4034972f80375d188bd5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e850f9fdd86a4034972f80375d188bd5
record_format	dspace
spelling	oai:doaj.org-article:e850f9fdd86a4034972f80375d188bd52021-12-04T16:05:09ZAssociation Between Colchicine Treatment and Clinical Outcomes in Patients with Coronary Artery Disease: Systematic Review and Meta-analysis10.15420/ecr.2021.311758-37641758-3756https://doaj.org/article/e850f9fdd86a4034972f80375d188bd52021-10-01T00:00:00Zhttps://www.ecrjournal.com/articleindex/ecr.2021.31https://doaj.org/toc/1758-3756https://doaj.org/toc/1758-3764Background: The authors examined the association between colchicine treatment and clinical outcomes in patients with coronary artery disease. Methods: They performed a meta-analysis of randomised controlled trials (RCTs) involving patients with coronary artery disease receiving add-on colchicine to standard treatment compared with standard treatment. They used a mixed-effects Poisson regression model with random intervention effects to estimate the pooled incidence rate ratios (IRR) with 95% CI. Results: Ten RCTs were identified, including 12,819 participants followed up for a median of 6 months. Colchicine was associated with a lower risk of major adverse cardiovascular events (IRR 0.69; 95% CI [0.60–0.79]; number needed to treat for an additional beneficial outcome [NNTB] = 28); MI (IRR 0.77; 95% CI [0.64–0.93]; NNTB = 95) and ischaemic stroke (IRR 0.48; 95% CI [0.30–0.76]; NNTB = 155) and with a higher risk of gastrointestinal adverse events (IRR 1.69; 95% CI [1.12–2.54]; number needed to treat for an additional harmful outcome [NNTH] = 10). Colchicine did not affect all-cause death (IRR 1.09; 95% CI [0.85–1.40]), or cardiovascular death (IRR 0.75; 95% CI [0.51–1.12]), while it was associated with a higher risk of non-cardiovascular death (IRR 1.45; 95% CI [1.04–2.02]; NNTH = 396). Conclusion: The meta-analysis showed that the relative and absolute beneficial treatment effects of colchicine on cardiovascular outcomes outweigh the potential harm for non-cardiovascular mortality. Registration: PROSPERO 2021 CRD42021248874.Francesco CondelloMatteo SturlaBernhard ReimersGaetano LiccardoGiulio G StefaniniGianluigi CondorelliGiuseppe FerranteRadcliffe Medical MediaarticleDiseases of the circulatory (Cardiovascular) systemRC666-701ENEuropean Cardiology Review , Vol 16, Iss , Pp - (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Diseases of the circulatory (Cardiovascular) system RC666-701 Francesco Condello Matteo Sturla Bernhard Reimers Gaetano Liccardo Giulio G Stefanini Gianluigi Condorelli Giuseppe Ferrante Association Between Colchicine Treatment and Clinical Outcomes in Patients with Coronary Artery Disease: Systematic Review and Meta-analysis
description	Background: The authors examined the association between colchicine treatment and clinical outcomes in patients with coronary artery disease. Methods: They performed a meta-analysis of randomised controlled trials (RCTs) involving patients with coronary artery disease receiving add-on colchicine to standard treatment compared with standard treatment. They used a mixed-effects Poisson regression model with random intervention effects to estimate the pooled incidence rate ratios (IRR) with 95% CI. Results: Ten RCTs were identified, including 12,819 participants followed up for a median of 6 months. Colchicine was associated with a lower risk of major adverse cardiovascular events (IRR 0.69; 95% CI [0.60–0.79]; number needed to treat for an additional beneficial outcome [NNTB] = 28); MI (IRR 0.77; 95% CI [0.64–0.93]; NNTB = 95) and ischaemic stroke (IRR 0.48; 95% CI [0.30–0.76]; NNTB = 155) and with a higher risk of gastrointestinal adverse events (IRR 1.69; 95% CI [1.12–2.54]; number needed to treat for an additional harmful outcome [NNTH] = 10). Colchicine did not affect all-cause death (IRR 1.09; 95% CI [0.85–1.40]), or cardiovascular death (IRR 0.75; 95% CI [0.51–1.12]), while it was associated with a higher risk of non-cardiovascular death (IRR 1.45; 95% CI [1.04–2.02]; NNTH = 396). Conclusion: The meta-analysis showed that the relative and absolute beneficial treatment effects of colchicine on cardiovascular outcomes outweigh the potential harm for non-cardiovascular mortality. Registration: PROSPERO 2021 CRD42021248874.
format	article
author	Francesco Condello Matteo Sturla Bernhard Reimers Gaetano Liccardo Giulio G Stefanini Gianluigi Condorelli Giuseppe Ferrante
author_facet	Francesco Condello Matteo Sturla Bernhard Reimers Gaetano Liccardo Giulio G Stefanini Gianluigi Condorelli Giuseppe Ferrante
author_sort	Francesco Condello
title	Association Between Colchicine Treatment and Clinical Outcomes in Patients with Coronary Artery Disease: Systematic Review and Meta-analysis
title_short	Association Between Colchicine Treatment and Clinical Outcomes in Patients with Coronary Artery Disease: Systematic Review and Meta-analysis
title_full	Association Between Colchicine Treatment and Clinical Outcomes in Patients with Coronary Artery Disease: Systematic Review and Meta-analysis
title_fullStr	Association Between Colchicine Treatment and Clinical Outcomes in Patients with Coronary Artery Disease: Systematic Review and Meta-analysis
title_full_unstemmed	Association Between Colchicine Treatment and Clinical Outcomes in Patients with Coronary Artery Disease: Systematic Review and Meta-analysis
title_sort	association between colchicine treatment and clinical outcomes in patients with coronary artery disease: systematic review and meta-analysis
publisher	Radcliffe Medical Media
publishDate	2021
url	https://doaj.org/article/e850f9fdd86a4034972f80375d188bd5
work_keys_str_mv	AT francescocondello associationbetweencolchicinetreatmentandclinicaloutcomesinpatientswithcoronaryarterydiseasesystematicreviewandmetaanalysis AT matteosturla associationbetweencolchicinetreatmentandclinicaloutcomesinpatientswithcoronaryarterydiseasesystematicreviewandmetaanalysis AT bernhardreimers associationbetweencolchicinetreatmentandclinicaloutcomesinpatientswithcoronaryarterydiseasesystematicreviewandmetaanalysis AT gaetanoliccardo associationbetweencolchicinetreatmentandclinicaloutcomesinpatientswithcoronaryarterydiseasesystematicreviewandmetaanalysis AT giuliogstefanini associationbetweencolchicinetreatmentandclinicaloutcomesinpatientswithcoronaryarterydiseasesystematicreviewandmetaanalysis AT gianluigicondorelli associationbetweencolchicinetreatmentandclinicaloutcomesinpatientswithcoronaryarterydiseasesystematicreviewandmetaanalysis AT giuseppeferrante associationbetweencolchicinetreatmentandclinicaloutcomesinpatientswithcoronaryarterydiseasesystematicreviewandmetaanalysis
_version_	1718372707552198656

Association Between Colchicine Treatment and Clinical Outcomes in Patients with Coronary Artery Disease: Systematic Review and Meta-analysis

Ejemplares similares