Clozapine As Transformative Treatment In Bipolar Patients

Alina Wilkowska, Wiesław J Cubała Department of Psychiatry, Medical University of Gdańsk, Gdańsk, PolandCorrespondence: Alina WilkowskaDepartment of Psychiatry, Medical University of Gdańsk, Dębinki 7, Gdańsk 80-211, PolandTel +48 58 349 2650Fax +48 349 2748Email ali.wilkowska@gmail.comAbstract: Clo...

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Autores principales: Wilkowska A, Cubała WJ
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2019
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Acceso en línea:https://doaj.org/article/e85114cfcb784a4781ede4aa9e9afe25
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Sumario:Alina Wilkowska, Wiesław J Cubała Department of Psychiatry, Medical University of Gdańsk, Gdańsk, PolandCorrespondence: Alina WilkowskaDepartment of Psychiatry, Medical University of Gdańsk, Dębinki 7, Gdańsk 80-211, PolandTel +48 58 349 2650Fax +48 349 2748Email ali.wilkowska@gmail.comAbstract: Clozapine is an atypical antipsychotic used in treatment-resistant bipolar disorder. There is evidence for its anti-suicidal, anti-aggressive properties and efficacy in substance use comorbidities. Despite guidelines, the drug is used in 1.5% of bipolar patients only. Considering its effectiveness in treatment-resistant cases as well as its epigenetic effects it may become transformative treatment in bipolar disorder impacting the clinical course and psychosocial burden of the disease.Keywords: clozapine, transformative treatment, bipolar disorder, treatment resistance