Clozapine As Transformative Treatment In Bipolar Patients

Alina Wilkowska, Wiesław J Cubała Department of Psychiatry, Medical University of Gdańsk, Gdańsk, PolandCorrespondence: Alina WilkowskaDepartment of Psychiatry, Medical University of Gdańsk, Dębinki 7, Gdańsk 80-211, PolandTel +48 58 349 2650Fax +48 349 2748Email ali.wilkowska@gmail.comAbstract: Clo...

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Autores principales:	Wilkowska A, Cubała WJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	clozapine transformative treatment bipolar disorder treatment resistance Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/e85114cfcb784a4781ede4aa9e9afe25
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spelling	oai:doaj.org-article:e85114cfcb784a4781ede4aa9e9afe252021-12-02T11:46:39ZClozapine As Transformative Treatment In Bipolar Patients1178-2021https://doaj.org/article/e85114cfcb784a4781ede4aa9e9afe252019-10-01T00:00:00Zhttps://www.dovepress.com/clozapine-as-transformative-treatment-in-bipolar-patients-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Alina Wilkowska, Wiesław J Cubała Department of Psychiatry, Medical University of Gdańsk, Gdańsk, PolandCorrespondence: Alina WilkowskaDepartment of Psychiatry, Medical University of Gdańsk, Dębinki 7, Gdańsk 80-211, PolandTel +48 58 349 2650Fax +48 349 2748Email ali.wilkowska@gmail.comAbstract: Clozapine is an atypical antipsychotic used in treatment-resistant bipolar disorder. There is evidence for its anti-suicidal, anti-aggressive properties and efficacy in substance use comorbidities. Despite guidelines, the drug is used in 1.5% of bipolar patients only. Considering its effectiveness in treatment-resistant cases as well as its epigenetic effects it may become transformative treatment in bipolar disorder impacting the clinical course and psychosocial burden of the disease.Keywords: clozapine, transformative treatment, bipolar disorder, treatment resistanceWilkowska ACubała WJDove Medical Pressarticleclozapinetransformative treatmentbipolar disordertreatment resistanceNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 2901-2905 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	clozapine transformative treatment bipolar disorder treatment resistance Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	clozapine transformative treatment bipolar disorder treatment resistance Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Wilkowska A Cubała WJ Clozapine As Transformative Treatment In Bipolar Patients
description	Alina Wilkowska, Wiesław J Cubała Department of Psychiatry, Medical University of Gdańsk, Gdańsk, PolandCorrespondence: Alina WilkowskaDepartment of Psychiatry, Medical University of Gdańsk, Dębinki 7, Gdańsk 80-211, PolandTel +48 58 349 2650Fax +48 349 2748Email ali.wilkowska@gmail.comAbstract: Clozapine is an atypical antipsychotic used in treatment-resistant bipolar disorder. There is evidence for its anti-suicidal, anti-aggressive properties and efficacy in substance use comorbidities. Despite guidelines, the drug is used in 1.5% of bipolar patients only. Considering its effectiveness in treatment-resistant cases as well as its epigenetic effects it may become transformative treatment in bipolar disorder impacting the clinical course and psychosocial burden of the disease.Keywords: clozapine, transformative treatment, bipolar disorder, treatment resistance
format	article
author	Wilkowska A Cubała WJ
author_facet	Wilkowska A Cubała WJ
author_sort	Wilkowska A
title	Clozapine As Transformative Treatment In Bipolar Patients
title_short	Clozapine As Transformative Treatment In Bipolar Patients
title_full	Clozapine As Transformative Treatment In Bipolar Patients
title_fullStr	Clozapine As Transformative Treatment In Bipolar Patients
title_full_unstemmed	Clozapine As Transformative Treatment In Bipolar Patients
title_sort	clozapine as transformative treatment in bipolar patients
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/e85114cfcb784a4781ede4aa9e9afe25
work_keys_str_mv	AT wilkowskaa clozapineastransformativetreatmentinbipolarpatients AT cubaławj clozapineastransformativetreatmentinbipolarpatients
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Clozapine As Transformative Treatment In Bipolar Patients

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