Lin−CCR2+ hematopoietic stem and progenitor cells overcome resistance to PD-1 blockade

Brain tumors are difficult to treat using existing immunotherapeutic strategies. Here, the authors show that in brain tumors resistant to PD-1 blockade, HSCs expressing CCR2+ can reverse treatment resistance and sensitizes mice to immunotherapy.

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Auteurs principaux:	Catherine T. Flores, Tyler J. Wildes, Jeffrey A. Drake, Ginger L. Moore, Bayli DiVita Dean, Rebecca S. Abraham, Duane A. Mitchell
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/e858bb0fbd22476293c8ca108b30024b
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id	oai:doaj.org-article:e858bb0fbd22476293c8ca108b30024b
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spelling	oai:doaj.org-article:e858bb0fbd22476293c8ca108b30024b2021-12-02T17:31:29ZLin−CCR2+ hematopoietic stem and progenitor cells overcome resistance to PD-1 blockade10.1038/s41467-018-06182-52041-1723https://doaj.org/article/e858bb0fbd22476293c8ca108b30024b2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06182-5https://doaj.org/toc/2041-1723Brain tumors are difficult to treat using existing immunotherapeutic strategies. Here, the authors show that in brain tumors resistant to PD-1 blockade, HSCs expressing CCR2+ can reverse treatment resistance and sensitizes mice to immunotherapy.Catherine T. FloresTyler J. WildesJeffrey A. DrakeGinger L. MooreBayli DiVita DeanRebecca S. AbrahamDuane A. MitchellNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Catherine T. Flores Tyler J. Wildes Jeffrey A. Drake Ginger L. Moore Bayli DiVita Dean Rebecca S. Abraham Duane A. Mitchell Lin−CCR2+ hematopoietic stem and progenitor cells overcome resistance to PD-1 blockade
description	Brain tumors are difficult to treat using existing immunotherapeutic strategies. Here, the authors show that in brain tumors resistant to PD-1 blockade, HSCs expressing CCR2+ can reverse treatment resistance and sensitizes mice to immunotherapy.
format	article
author	Catherine T. Flores Tyler J. Wildes Jeffrey A. Drake Ginger L. Moore Bayli DiVita Dean Rebecca S. Abraham Duane A. Mitchell
author_facet	Catherine T. Flores Tyler J. Wildes Jeffrey A. Drake Ginger L. Moore Bayli DiVita Dean Rebecca S. Abraham Duane A. Mitchell
author_sort	Catherine T. Flores
title	Lin−CCR2+ hematopoietic stem and progenitor cells overcome resistance to PD-1 blockade
title_short	Lin−CCR2+ hematopoietic stem and progenitor cells overcome resistance to PD-1 blockade
title_full	Lin−CCR2+ hematopoietic stem and progenitor cells overcome resistance to PD-1 blockade
title_fullStr	Lin−CCR2+ hematopoietic stem and progenitor cells overcome resistance to PD-1 blockade
title_full_unstemmed	Lin−CCR2+ hematopoietic stem and progenitor cells overcome resistance to PD-1 blockade
title_sort	lin−ccr2+ hematopoietic stem and progenitor cells overcome resistance to pd-1 blockade
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e858bb0fbd22476293c8ca108b30024b
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Lin−CCR2+ hematopoietic stem and progenitor cells overcome resistance to PD-1 blockade

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