Virtual cardiac monolayers for electrical wave propagation

Abstract The complex structure of cardiac tissue is considered to be one of the main determinants of an arrhythmogenic substrate. This study is aimed at developing the first mathematical model to describe the formation of cardiac tissue, using a joint in silico–in vitro approach. First, we performed...

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Autores principales:	Nina Kudryashova, Valeriya Tsvelaya, Konstantin Agladze, Alexander Panfilov
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e8591d80c84f41ce93e998606387be65
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spelling	oai:doaj.org-article:e8591d80c84f41ce93e998606387be652021-12-02T11:40:13ZVirtual cardiac monolayers for electrical wave propagation10.1038/s41598-017-07653-32045-2322https://doaj.org/article/e8591d80c84f41ce93e998606387be652017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07653-3https://doaj.org/toc/2045-2322Abstract The complex structure of cardiac tissue is considered to be one of the main determinants of an arrhythmogenic substrate. This study is aimed at developing the first mathematical model to describe the formation of cardiac tissue, using a joint in silico–in vitro approach. First, we performed experiments under various conditions to carefully characterise the morphology of cardiac tissue in a culture of neonatal rat ventricular cells. We considered two cell types, namely, cardiomyocytes and fibroblasts. Next, we proposed a mathematical model, based on the Glazier-Graner-Hogeweg model, which is widely used in tissue growth studies. The resultant tissue morphology was coupled to the detailed electrophysiological Korhonen-Majumder model for neonatal rat ventricular cardiomyocytes, in order to study wave propagation. The simulated waves had the same anisotropy ratio and wavefront complexity as those in the experiment. Thus, we conclude that our approach allows us to reproduce the morphological and physiological properties of cardiac tissue.Nina KudryashovaValeriya TsvelayaKonstantin AgladzeAlexander PanfilovNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-19 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nina Kudryashova Valeriya Tsvelaya Konstantin Agladze Alexander Panfilov Virtual cardiac monolayers for electrical wave propagation
description	Abstract The complex structure of cardiac tissue is considered to be one of the main determinants of an arrhythmogenic substrate. This study is aimed at developing the first mathematical model to describe the formation of cardiac tissue, using a joint in silico–in vitro approach. First, we performed experiments under various conditions to carefully characterise the morphology of cardiac tissue in a culture of neonatal rat ventricular cells. We considered two cell types, namely, cardiomyocytes and fibroblasts. Next, we proposed a mathematical model, based on the Glazier-Graner-Hogeweg model, which is widely used in tissue growth studies. The resultant tissue morphology was coupled to the detailed electrophysiological Korhonen-Majumder model for neonatal rat ventricular cardiomyocytes, in order to study wave propagation. The simulated waves had the same anisotropy ratio and wavefront complexity as those in the experiment. Thus, we conclude that our approach allows us to reproduce the morphological and physiological properties of cardiac tissue.
format	article
author	Nina Kudryashova Valeriya Tsvelaya Konstantin Agladze Alexander Panfilov
author_facet	Nina Kudryashova Valeriya Tsvelaya Konstantin Agladze Alexander Panfilov
author_sort	Nina Kudryashova
title	Virtual cardiac monolayers for electrical wave propagation
title_short	Virtual cardiac monolayers for electrical wave propagation
title_full	Virtual cardiac monolayers for electrical wave propagation
title_fullStr	Virtual cardiac monolayers for electrical wave propagation
title_full_unstemmed	Virtual cardiac monolayers for electrical wave propagation
title_sort	virtual cardiac monolayers for electrical wave propagation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e8591d80c84f41ce93e998606387be65
work_keys_str_mv	AT ninakudryashova virtualcardiacmonolayersforelectricalwavepropagation AT valeriyatsvelaya virtualcardiacmonolayersforelectricalwavepropagation AT konstantinagladze virtualcardiacmonolayersforelectricalwavepropagation AT alexanderpanfilov virtualcardiacmonolayersforelectricalwavepropagation
_version_	1718395734470950912

Virtual cardiac monolayers for electrical wave propagation

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