The histone chaperone NAP1L3 is required for haematopoietic stem cell maintenance and differentiation

The histone chaperone NAP1L3 is required for haematopoietic stem cell maintenance and differentiation

Abstract Nucleosome assembly proteins (NAPs) are histone chaperones with an important role in chromatin structure and epigenetic regulation of gene expression. We find that high gene expression levels of mouse Nap1l3 are restricted to haematopoietic stem cells (HSCs) in mice. Importantly, with shRNA...

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Autores principales: Yaser Heshmati, Shabnam Kharazi, Gözde Türköz, David Chang, Esmat Kamali Dolatabadi, Johan Boström, Aleksandra Krstic, Theodora Boukoura, Emma Wagner, Nadir Kadri, Robert Månsson, Mikael Altun, Hong Qian, Julian Walfridsson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/e85ae0005d43458ea0e54cc10c6d246f
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