Digital Biomarkers for the Objective Assessment of Disability in Neurogenic Thoracic Outlet Syndrome

Neurogenic thoracic outlet syndrome (nTOS) is a musculoskeletal disorder in which compression of the brachial plexus between the scalene muscles of the neck and the first rib results in disabling upper extremity pain and paresthesia. Currently there are no objective metrics for assessing the disabil...

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Autores principales:	Bijan Najafi, Mohsen Zahiri, Changhong Wang, Anmol Momin, Paul Paily, Bryan M. Burt
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	thoracic outlet syndrome wearables sensors disability digital health upper extremity Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/e85c4300e99f40548e432ca1f53deb70
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spelling	oai:doaj.org-article:e85c4300e99f40548e432ca1f53deb702021-11-25T18:56:39ZDigital Biomarkers for the Objective Assessment of Disability in Neurogenic Thoracic Outlet Syndrome10.3390/s212274621424-8220https://doaj.org/article/e85c4300e99f40548e432ca1f53deb702021-11-01T00:00:00Zhttps://www.mdpi.com/1424-8220/21/22/7462https://doaj.org/toc/1424-8220Neurogenic thoracic outlet syndrome (nTOS) is a musculoskeletal disorder in which compression of the brachial plexus between the scalene muscles of the neck and the first rib results in disabling upper extremity pain and paresthesia. Currently there are no objective metrics for assessing the disability of nTOS or for monitoring response to its therapy. We aimed to develop digital biomarkers of upper extremity motor capacity that could objectively measure the disability of nTOS using an upper arm inertial sensor and a 20-s upper extremity task that provokes nTOS symptoms. We found that digital biomarkers of slowness, power, and rigidity statistically differentiated the affected extremities of patients with nTOS from their contralateral extremities (n = 16) and from the extremities of healthy controls (n = 13); speed and power had the highest effect sizes. Digital biomarkers representing slowness, power, and rigidity correlated with patient-reported outcomes collected with the Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire and the visual analog scale of pain (VAS); speed had the highest correlation. Digital biomarkers of exhaustion correlated with failure of physical therapy in treating nTOS; and digital biomarkers of slowness, power, and exhaustion correlated with favorable response to nTOS surgery. In conclusion, sensor-derived digital biomarkers can objectively assess the impairment of motor capacity resultant from nTOS, and correlate with patient-reported symptoms and response to therapy.Bijan NajafiMohsen ZahiriChanghong WangAnmol MominPaul PailyBryan M. BurtMDPI AGarticlethoracic outlet syndromewearablessensorsdisabilitydigital healthupper extremityChemical technologyTP1-1185ENSensors, Vol 21, Iss 7462, p 7462 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	thoracic outlet syndrome wearables sensors disability digital health upper extremity Chemical technology TP1-1185
spellingShingle	thoracic outlet syndrome wearables sensors disability digital health upper extremity Chemical technology TP1-1185 Bijan Najafi Mohsen Zahiri Changhong Wang Anmol Momin Paul Paily Bryan M. Burt Digital Biomarkers for the Objective Assessment of Disability in Neurogenic Thoracic Outlet Syndrome
description	Neurogenic thoracic outlet syndrome (nTOS) is a musculoskeletal disorder in which compression of the brachial plexus between the scalene muscles of the neck and the first rib results in disabling upper extremity pain and paresthesia. Currently there are no objective metrics for assessing the disability of nTOS or for monitoring response to its therapy. We aimed to develop digital biomarkers of upper extremity motor capacity that could objectively measure the disability of nTOS using an upper arm inertial sensor and a 20-s upper extremity task that provokes nTOS symptoms. We found that digital biomarkers of slowness, power, and rigidity statistically differentiated the affected extremities of patients with nTOS from their contralateral extremities (n = 16) and from the extremities of healthy controls (n = 13); speed and power had the highest effect sizes. Digital biomarkers representing slowness, power, and rigidity correlated with patient-reported outcomes collected with the Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire and the visual analog scale of pain (VAS); speed had the highest correlation. Digital biomarkers of exhaustion correlated with failure of physical therapy in treating nTOS; and digital biomarkers of slowness, power, and exhaustion correlated with favorable response to nTOS surgery. In conclusion, sensor-derived digital biomarkers can objectively assess the impairment of motor capacity resultant from nTOS, and correlate with patient-reported symptoms and response to therapy.
format	article
author	Bijan Najafi Mohsen Zahiri Changhong Wang Anmol Momin Paul Paily Bryan M. Burt
author_facet	Bijan Najafi Mohsen Zahiri Changhong Wang Anmol Momin Paul Paily Bryan M. Burt
author_sort	Bijan Najafi
title	Digital Biomarkers for the Objective Assessment of Disability in Neurogenic Thoracic Outlet Syndrome
title_short	Digital Biomarkers for the Objective Assessment of Disability in Neurogenic Thoracic Outlet Syndrome
title_full	Digital Biomarkers for the Objective Assessment of Disability in Neurogenic Thoracic Outlet Syndrome
title_fullStr	Digital Biomarkers for the Objective Assessment of Disability in Neurogenic Thoracic Outlet Syndrome
title_full_unstemmed	Digital Biomarkers for the Objective Assessment of Disability in Neurogenic Thoracic Outlet Syndrome
title_sort	digital biomarkers for the objective assessment of disability in neurogenic thoracic outlet syndrome
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e85c4300e99f40548e432ca1f53deb70
work_keys_str_mv	AT bijannajafi digitalbiomarkersfortheobjectiveassessmentofdisabilityinneurogenicthoracicoutletsyndrome AT mohsenzahiri digitalbiomarkersfortheobjectiveassessmentofdisabilityinneurogenicthoracicoutletsyndrome AT changhongwang digitalbiomarkersfortheobjectiveassessmentofdisabilityinneurogenicthoracicoutletsyndrome AT anmolmomin digitalbiomarkersfortheobjectiveassessmentofdisabilityinneurogenicthoracicoutletsyndrome AT paulpaily digitalbiomarkersfortheobjectiveassessmentofdisabilityinneurogenicthoracicoutletsyndrome AT bryanmburt digitalbiomarkersfortheobjectiveassessmentofdisabilityinneurogenicthoracicoutletsyndrome
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Digital Biomarkers for the Objective Assessment of Disability in Neurogenic Thoracic Outlet Syndrome

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