Prognostic value of high-expression of miR-17-92 cluster in various tumors: evidence from a meta-analysis

Prognostic value of high-expression of miR-17-92 cluster in various tumors: evidence from a meta-analysis

Abstract The prognostic value of miR-17-92 cluster high-expression in various tumors remains controversial. Therefore, we conducted this meta-analysis by searching literatures in PubMed, Embase, Cochrane Library, China Biology Medicine disc, China National Knowledge Infrastructure to identify eligib...

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Autores principales: Kaiping Zhang, Li Zhang, Meng Zhang, Yin Zhang, Dengxin Fan, Jiabin Jiang, Liqin Ye, Xiang Fang, Xianguo Chen, Song Fan, Min Chao, Chaozhao Liang
Formato: article
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Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/e85c65eb8c6b48be891b1625217c0932
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spelling oai:doaj.org-article:e85c65eb8c6b48be891b1625217c09322021-12-02T16:06:49ZPrognostic value of high-expression of miR-17-92 cluster in various tumors: evidence from a meta-analysis10.1038/s41598-017-08349-42045-2322https://doaj.org/article/e85c65eb8c6b48be891b1625217c09322017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08349-4https://doaj.org/toc/2045-2322Abstract The prognostic value of miR-17-92 cluster high-expression in various tumors remains controversial. Therefore, we conducted this meta-analysis by searching literatures in PubMed, Embase, Cochrane Library, China Biology Medicine disc, China National Knowledge Infrastructure to identify eligible studies. Eventually, we analyzed 36 articles that examined 17 tumor types from 4965 patients. Consequently, high-expression of miR-17-92 cluster in various tumors was associated with unfavorable overall survival in both univariate (HR = 2.05, 95%CI: 1.58–2.65, P<0.001) and multivariate (HR = 2.14, 95%CI: 1.75–2.61, P<0.001) analyses. Likewise, similar results were found in different subgroups of country, test method, miR-17-92 cluster component, sample source and size. Additionally, high-expression of miR-17-92 cluster was linked with poor disease-free survival (Univariate: HR = 1.96, 95%CI: 1.55–2.48, P<0.001; Multivariate: HR = 2.18, 95%CI: 1.63–2.91, P<0.001), favorable progression-free survival (Univariate: HR = 0.36, 95%CI: 0.16–0.80, P = 0.012; Multivariate: HR = 1.55, 95%CI: 0.79–3.05, P = 0.201) and poor cancer specific survival in univariate rather than multivariate analyses (Univariate: HR = 1.77, 95%CI: 1.21–2.60, P = 0.004; Multivariate: HR = 1.77, 95%CI: 0.80–3.92, P = 0.160). However, no association of miR-17-92 cluster high-expression was detected with recurrence or relapse-free survival. In summary, this meta-analysis towards high-expression of miR-17-92 cluster has indicated poor prognosis of various cancers. Notably, future studies comprising large cohort size from multicenter are required to confirm our conclusions.Kaiping ZhangLi ZhangMeng ZhangYin ZhangDengxin FanJiabin JiangLiqin YeXiang FangXianguo ChenSong FanMin ChaoChaozhao LiangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Kaiping Zhang
Li Zhang
Meng Zhang
Yin Zhang
Dengxin Fan
Jiabin Jiang
Liqin Ye
Xiang Fang
Xianguo Chen
Song Fan
Min Chao
Chaozhao Liang
Prognostic value of high-expression of miR-17-92 cluster in various tumors: evidence from a meta-analysis
description Abstract The prognostic value of miR-17-92 cluster high-expression in various tumors remains controversial. Therefore, we conducted this meta-analysis by searching literatures in PubMed, Embase, Cochrane Library, China Biology Medicine disc, China National Knowledge Infrastructure to identify eligible studies. Eventually, we analyzed 36 articles that examined 17 tumor types from 4965 patients. Consequently, high-expression of miR-17-92 cluster in various tumors was associated with unfavorable overall survival in both univariate (HR = 2.05, 95%CI: 1.58–2.65, P<0.001) and multivariate (HR = 2.14, 95%CI: 1.75–2.61, P<0.001) analyses. Likewise, similar results were found in different subgroups of country, test method, miR-17-92 cluster component, sample source and size. Additionally, high-expression of miR-17-92 cluster was linked with poor disease-free survival (Univariate: HR = 1.96, 95%CI: 1.55–2.48, P<0.001; Multivariate: HR = 2.18, 95%CI: 1.63–2.91, P<0.001), favorable progression-free survival (Univariate: HR = 0.36, 95%CI: 0.16–0.80, P = 0.012; Multivariate: HR = 1.55, 95%CI: 0.79–3.05, P = 0.201) and poor cancer specific survival in univariate rather than multivariate analyses (Univariate: HR = 1.77, 95%CI: 1.21–2.60, P = 0.004; Multivariate: HR = 1.77, 95%CI: 0.80–3.92, P = 0.160). However, no association of miR-17-92 cluster high-expression was detected with recurrence or relapse-free survival. In summary, this meta-analysis towards high-expression of miR-17-92 cluster has indicated poor prognosis of various cancers. Notably, future studies comprising large cohort size from multicenter are required to confirm our conclusions.
format article
author Kaiping Zhang
Li Zhang
Meng Zhang
Yin Zhang
Dengxin Fan
Jiabin Jiang
Liqin Ye
Xiang Fang
Xianguo Chen
Song Fan
Min Chao
Chaozhao Liang
author_facet Kaiping Zhang
Li Zhang
Meng Zhang
Yin Zhang
Dengxin Fan
Jiabin Jiang
Liqin Ye
Xiang Fang
Xianguo Chen
Song Fan
Min Chao
Chaozhao Liang
author_sort Kaiping Zhang
title Prognostic value of high-expression of miR-17-92 cluster in various tumors: evidence from a meta-analysis
title_short Prognostic value of high-expression of miR-17-92 cluster in various tumors: evidence from a meta-analysis
title_full Prognostic value of high-expression of miR-17-92 cluster in various tumors: evidence from a meta-analysis
title_fullStr Prognostic value of high-expression of miR-17-92 cluster in various tumors: evidence from a meta-analysis
title_full_unstemmed Prognostic value of high-expression of miR-17-92 cluster in various tumors: evidence from a meta-analysis
title_sort prognostic value of high-expression of mir-17-92 cluster in various tumors: evidence from a meta-analysis
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/e85c65eb8c6b48be891b1625217c0932
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