Eya3 partners with PP2A to induce c-Myc stabilization and tumor progression

Eya proteins are characterised by phosphatase activity associated with both the evolutionary conserved region and the less conserved N-terminal domain (NTD). Here the authors show that NTD mediates the interaction with PP2A and regulates c-Myc phosphorylation and stability, potentially switching PP2...

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Autores principales:	Lingdi Zhang, Hengbo Zhou, Xueni Li, Rebecca L Vartuli, Michael Rowse, Yongna Xing, Pratyaydipta Rudra, Debashis Ghosh, Rui Zhao, Heide L Ford
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e85d17f3da1b488cb955698e3352b45c
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spelling	oai:doaj.org-article:e85d17f3da1b488cb955698e3352b45c2021-12-02T15:34:27ZEya3 partners with PP2A to induce c-Myc stabilization and tumor progression10.1038/s41467-018-03327-42041-1723https://doaj.org/article/e85d17f3da1b488cb955698e3352b45c2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03327-4https://doaj.org/toc/2041-1723Eya proteins are characterised by phosphatase activity associated with both the evolutionary conserved region and the less conserved N-terminal domain (NTD). Here the authors show that NTD mediates the interaction with PP2A and regulates c-Myc phosphorylation and stability, potentially switching PP2A from a tumour suppressor to an oncogene.Lingdi ZhangHengbo ZhouXueni LiRebecca L VartuliMichael RowseYongna XingPratyaydipta RudraDebashis GhoshRui ZhaoHeide L FordNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lingdi Zhang Hengbo Zhou Xueni Li Rebecca L Vartuli Michael Rowse Yongna Xing Pratyaydipta Rudra Debashis Ghosh Rui Zhao Heide L Ford Eya3 partners with PP2A to induce c-Myc stabilization and tumor progression
description	Eya proteins are characterised by phosphatase activity associated with both the evolutionary conserved region and the less conserved N-terminal domain (NTD). Here the authors show that NTD mediates the interaction with PP2A and regulates c-Myc phosphorylation and stability, potentially switching PP2A from a tumour suppressor to an oncogene.
format	article
author	Lingdi Zhang Hengbo Zhou Xueni Li Rebecca L Vartuli Michael Rowse Yongna Xing Pratyaydipta Rudra Debashis Ghosh Rui Zhao Heide L Ford
author_facet	Lingdi Zhang Hengbo Zhou Xueni Li Rebecca L Vartuli Michael Rowse Yongna Xing Pratyaydipta Rudra Debashis Ghosh Rui Zhao Heide L Ford
author_sort	Lingdi Zhang
title	Eya3 partners with PP2A to induce c-Myc stabilization and tumor progression
title_short	Eya3 partners with PP2A to induce c-Myc stabilization and tumor progression
title_full	Eya3 partners with PP2A to induce c-Myc stabilization and tumor progression
title_fullStr	Eya3 partners with PP2A to induce c-Myc stabilization and tumor progression
title_full_unstemmed	Eya3 partners with PP2A to induce c-Myc stabilization and tumor progression
title_sort	eya3 partners with pp2a to induce c-myc stabilization and tumor progression
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e85d17f3da1b488cb955698e3352b45c
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Eya3 partners with PP2A to induce c-Myc stabilization and tumor progression

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