STUDY OF APOPTOSIS OF IMMUNE CELLS IN TYPE 1 DIABETES MELLITUS

Type 1 diabetic mellitus (T1DM) is known to be associated with progressive destruction of β-cells of the pancreas. Dysregulated immunity and programmed cell death are an important link in pathogenesis of diabetes. In this study, we examined expression levels of interleukin-2, Bcl-1, ANXA-11 genes in...

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Autores principales:	L. M. Hovsepyan, G. S. Kazaryan, A. V. Zanginyan, A. A. Akopdzhanyan, G. V. Zakharyan, Martin Petrek
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2017
Materias:	diabetes leukocytes interleukin-2 annexin proliferation apoptosis Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/e860f634dd8d4f8b93909c52f9869335
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spelling	oai:doaj.org-article:e860f634dd8d4f8b93909c52f98693352021-11-18T08:03:46ZSTUDY OF APOPTOSIS OF IMMUNE CELLS IN TYPE 1 DIABETES MELLITUS1563-06252313-741X10.15789/1563-0625-2017-5-635-640https://doaj.org/article/e860f634dd8d4f8b93909c52f98693352017-10-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1365https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XType 1 diabetic mellitus (T1DM) is known to be associated with progressive destruction of β-cells of the pancreas. Dysregulated immunity and programmed cell death are an important link in pathogenesis of diabetes. In this study, we examined expression levels of interleukin-2, Bcl-1, ANXA-11 genes in patients with T1DM. The study was done with blood leukocures of T1DM patients (30) and healthy controls (70). Reverse-transcription PCR was done with Transcriptor First Strand cDNA Synthesis Kit from Roche Life Science. The study of IL-2 and Bcl-1 gene expression level in peripheral blood leukocytes indicated that the median gene expression levels of IL-2 and Bcl-1 are increased in patients with T1DM patients compared with control group of healthy persons. The study of apoptosis by annexin test has revealed an increased level of ANXA 11 expression in T1DM patients. The obtained data can serve as an additional source for understanding the pathogenesis of T1DM mechanisms.L. M. HovsepyanG. S. KazaryanA. V. ZanginyanA. A. AkopdzhanyanG. V. ZakharyanMartin PetrekSPb RAACIarticlediabetesleukocytesinterleukin-2annexinproliferationapoptosisImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 19, Iss 5, Pp 635-640 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	diabetes leukocytes interleukin-2 annexin proliferation apoptosis Immunologic diseases. Allergy RC581-607
spellingShingle	diabetes leukocytes interleukin-2 annexin proliferation apoptosis Immunologic diseases. Allergy RC581-607 L. M. Hovsepyan G. S. Kazaryan A. V. Zanginyan A. A. Akopdzhanyan G. V. Zakharyan Martin Petrek STUDY OF APOPTOSIS OF IMMUNE CELLS IN TYPE 1 DIABETES MELLITUS
description	Type 1 diabetic mellitus (T1DM) is known to be associated with progressive destruction of β-cells of the pancreas. Dysregulated immunity and programmed cell death are an important link in pathogenesis of diabetes. In this study, we examined expression levels of interleukin-2, Bcl-1, ANXA-11 genes in patients with T1DM. The study was done with blood leukocures of T1DM patients (30) and healthy controls (70). Reverse-transcription PCR was done with Transcriptor First Strand cDNA Synthesis Kit from Roche Life Science. The study of IL-2 and Bcl-1 gene expression level in peripheral blood leukocytes indicated that the median gene expression levels of IL-2 and Bcl-1 are increased in patients with T1DM patients compared with control group of healthy persons. The study of apoptosis by annexin test has revealed an increased level of ANXA 11 expression in T1DM patients. The obtained data can serve as an additional source for understanding the pathogenesis of T1DM mechanisms.
format	article
author	L. M. Hovsepyan G. S. Kazaryan A. V. Zanginyan A. A. Akopdzhanyan G. V. Zakharyan Martin Petrek
author_facet	L. M. Hovsepyan G. S. Kazaryan A. V. Zanginyan A. A. Akopdzhanyan G. V. Zakharyan Martin Petrek
author_sort	L. M. Hovsepyan
title	STUDY OF APOPTOSIS OF IMMUNE CELLS IN TYPE 1 DIABETES MELLITUS
title_short	STUDY OF APOPTOSIS OF IMMUNE CELLS IN TYPE 1 DIABETES MELLITUS
title_full	STUDY OF APOPTOSIS OF IMMUNE CELLS IN TYPE 1 DIABETES MELLITUS
title_fullStr	STUDY OF APOPTOSIS OF IMMUNE CELLS IN TYPE 1 DIABETES MELLITUS
title_full_unstemmed	STUDY OF APOPTOSIS OF IMMUNE CELLS IN TYPE 1 DIABETES MELLITUS
title_sort	study of apoptosis of immune cells in type 1 diabetes mellitus
publisher	SPb RAACI
publishDate	2017
url	https://doaj.org/article/e860f634dd8d4f8b93909c52f9869335
work_keys_str_mv	AT lmhovsepyan studyofapoptosisofimmunecellsintype1diabetesmellitus AT gskazaryan studyofapoptosisofimmunecellsintype1diabetesmellitus AT avzanginyan studyofapoptosisofimmunecellsintype1diabetesmellitus AT aaakopdzhanyan studyofapoptosisofimmunecellsintype1diabetesmellitus AT gvzakharyan studyofapoptosisofimmunecellsintype1diabetesmellitus AT martinpetrek studyofapoptosisofimmunecellsintype1diabetesmellitus
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STUDY OF APOPTOSIS OF IMMUNE CELLS IN TYPE 1 DIABETES MELLITUS

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