Impact of the molar activity and PSMA expression level on [18F]AlF-PSMA-11 uptake in prostate cancer

Abstract This two-part preclinical study aims to evaluate prostate specific membrane antigen (PSMA) as a valuable target for expression-based imaging applications and to determine changes in target binding in function of varying apparent molar activities (MAapp) of [18F]AlF-PSMA-11. For the evaluati...

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Autores principales:	Sarah Piron, Jeroen Verhoeven, Emma De Coster, Benedicte Descamps, Ken Kersemans, Leen Pieters, Anne Vral, Christian Vanhove, Filip De Vos
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e86245019d2c44038a8b1e90bc80cbd1
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spelling	oai:doaj.org-article:e86245019d2c44038a8b1e90bc80cbd12021-11-21T12:24:44ZImpact of the molar activity and PSMA expression level on [18F]AlF-PSMA-11 uptake in prostate cancer10.1038/s41598-021-02104-62045-2322https://doaj.org/article/e86245019d2c44038a8b1e90bc80cbd12021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02104-6https://doaj.org/toc/2045-2322Abstract This two-part preclinical study aims to evaluate prostate specific membrane antigen (PSMA) as a valuable target for expression-based imaging applications and to determine changes in target binding in function of varying apparent molar activities (MAapp) of [18F]AlF-PSMA-11. For the evaluation of PSMA expression levels, male NOD/SCID mice bearing prostate cancer (PCa) xenografts of C4-2 (PSMA+++), 22Rv1 (PSMA+) and PC-3 (PSMA−) were administered [18F]AlF-PSMA-11 with a medium MAapp (20.24 ± 3.22 MBq/nmol). SUVmean and SUVmax values were respectively 3.22 and 3.17 times higher for the high versus low PSMA expressing tumors (p < 0.0001). To evaluate the effect of varying MAapp, C4-2 and 22Rv1 xenograft bearing mice underwent additional [18F]AlF-PSMA-11 imaging with a high (211.2 ± 38.9 MBq/nmol) and/or low MAapp (1.92 ± 0.27 MBq/nmol). SUV values showed a significantly increasing trend with higher MAapp. Significant changes were found for SUVmean and SUVmax between the high versus low MAapp and medium versus low MAapp (both p < 0.05), but not between the high versus medium MAapp (p = 0.055 and 0.25, respectively). The effect of varying MAapp was more pronounced in low expressing tumors and PSMA expressing tissues (e.g. salivary glands and kidneys). Overall, administration of a high MAapp increases the detection of low expression tumors while also increasing uptake in PSMA expressing tissues, possibly leading to false positive findings. In radioligand therapy, a medium MAapp could reduce radiation exposure to dose-limiting organs with only limited effect on radionuclide accumulation in the tumor.Sarah PironJeroen VerhoevenEmma De CosterBenedicte DescampsKen KersemansLeen PietersAnne VralChristian VanhoveFilip De VosNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sarah Piron Jeroen Verhoeven Emma De Coster Benedicte Descamps Ken Kersemans Leen Pieters Anne Vral Christian Vanhove Filip De Vos Impact of the molar activity and PSMA expression level on [18F]AlF-PSMA-11 uptake in prostate cancer
description	Abstract This two-part preclinical study aims to evaluate prostate specific membrane antigen (PSMA) as a valuable target for expression-based imaging applications and to determine changes in target binding in function of varying apparent molar activities (MAapp) of [18F]AlF-PSMA-11. For the evaluation of PSMA expression levels, male NOD/SCID mice bearing prostate cancer (PCa) xenografts of C4-2 (PSMA+++), 22Rv1 (PSMA+) and PC-3 (PSMA−) were administered [18F]AlF-PSMA-11 with a medium MAapp (20.24 ± 3.22 MBq/nmol). SUVmean and SUVmax values were respectively 3.22 and 3.17 times higher for the high versus low PSMA expressing tumors (p < 0.0001). To evaluate the effect of varying MAapp, C4-2 and 22Rv1 xenograft bearing mice underwent additional [18F]AlF-PSMA-11 imaging with a high (211.2 ± 38.9 MBq/nmol) and/or low MAapp (1.92 ± 0.27 MBq/nmol). SUV values showed a significantly increasing trend with higher MAapp. Significant changes were found for SUVmean and SUVmax between the high versus low MAapp and medium versus low MAapp (both p < 0.05), but not between the high versus medium MAapp (p = 0.055 and 0.25, respectively). The effect of varying MAapp was more pronounced in low expressing tumors and PSMA expressing tissues (e.g. salivary glands and kidneys). Overall, administration of a high MAapp increases the detection of low expression tumors while also increasing uptake in PSMA expressing tissues, possibly leading to false positive findings. In radioligand therapy, a medium MAapp could reduce radiation exposure to dose-limiting organs with only limited effect on radionuclide accumulation in the tumor.
format	article
author	Sarah Piron Jeroen Verhoeven Emma De Coster Benedicte Descamps Ken Kersemans Leen Pieters Anne Vral Christian Vanhove Filip De Vos
author_facet	Sarah Piron Jeroen Verhoeven Emma De Coster Benedicte Descamps Ken Kersemans Leen Pieters Anne Vral Christian Vanhove Filip De Vos
author_sort	Sarah Piron
title	Impact of the molar activity and PSMA expression level on [18F]AlF-PSMA-11 uptake in prostate cancer
title_short	Impact of the molar activity and PSMA expression level on [18F]AlF-PSMA-11 uptake in prostate cancer
title_full	Impact of the molar activity and PSMA expression level on [18F]AlF-PSMA-11 uptake in prostate cancer
title_fullStr	Impact of the molar activity and PSMA expression level on [18F]AlF-PSMA-11 uptake in prostate cancer
title_full_unstemmed	Impact of the molar activity and PSMA expression level on [18F]AlF-PSMA-11 uptake in prostate cancer
title_sort	impact of the molar activity and psma expression level on [18f]alf-psma-11 uptake in prostate cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e86245019d2c44038a8b1e90bc80cbd1
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Impact of the molar activity and PSMA expression level on [18F]AlF-PSMA-11 uptake in prostate cancer

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