The CCR4–NOT deadenylase complex safeguards thymic positive selection by down-regulating aberrant pro-apoptotic gene expression
The CCR4-NOT complex catalyzes mRNA deadenylation and hence regulates protein translation. Here the authors show that CNOT3 regulation of this complex is needed for positive selection of thymocytes via a mechanism involving inhibition of pro-apoptotic gene expression.
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Nature Portfolio
2020
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oai:doaj.org-article:e8632bde18164a9fa0e055cc88ae0bea2021-12-02T16:56:32ZThe CCR4–NOT deadenylase complex safeguards thymic positive selection by down-regulating aberrant pro-apoptotic gene expression10.1038/s41467-020-19975-42041-1723https://doaj.org/article/e8632bde18164a9fa0e055cc88ae0bea2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19975-4https://doaj.org/toc/2041-1723The CCR4-NOT complex catalyzes mRNA deadenylation and hence regulates protein translation. Here the authors show that CNOT3 regulation of this complex is needed for positive selection of thymocytes via a mechanism involving inhibition of pro-apoptotic gene expression.Taku Ito-KurehaTakahisa MiyaoSaori NishijimaToru SuzukiShin-ichi KoizumiAlejandro Villar-BrionesAkinori TakahashiNobuko AkiyamaMasahiro MoritaIsao NaguroHiroki IshikawaHidenori IchijoTaishin AkiyamaTadashi YamamotoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Taku Ito-Kureha Takahisa Miyao Saori Nishijima Toru Suzuki Shin-ichi Koizumi Alejandro Villar-Briones Akinori Takahashi Nobuko Akiyama Masahiro Morita Isao Naguro Hiroki Ishikawa Hidenori Ichijo Taishin Akiyama Tadashi Yamamoto The CCR4–NOT deadenylase complex safeguards thymic positive selection by down-regulating aberrant pro-apoptotic gene expression |
| description |
The CCR4-NOT complex catalyzes mRNA deadenylation and hence regulates protein translation. Here the authors show that CNOT3 regulation of this complex is needed for positive selection of thymocytes via a mechanism involving inhibition of pro-apoptotic gene expression. |
| format |
article |
| author |
Taku Ito-Kureha Takahisa Miyao Saori Nishijima Toru Suzuki Shin-ichi Koizumi Alejandro Villar-Briones Akinori Takahashi Nobuko Akiyama Masahiro Morita Isao Naguro Hiroki Ishikawa Hidenori Ichijo Taishin Akiyama Tadashi Yamamoto |
| author_facet |
Taku Ito-Kureha Takahisa Miyao Saori Nishijima Toru Suzuki Shin-ichi Koizumi Alejandro Villar-Briones Akinori Takahashi Nobuko Akiyama Masahiro Morita Isao Naguro Hiroki Ishikawa Hidenori Ichijo Taishin Akiyama Tadashi Yamamoto |
| author_sort |
Taku Ito-Kureha |
| title |
The CCR4–NOT deadenylase complex safeguards thymic positive selection by down-regulating aberrant pro-apoptotic gene expression |
| title_short |
The CCR4–NOT deadenylase complex safeguards thymic positive selection by down-regulating aberrant pro-apoptotic gene expression |
| title_full |
The CCR4–NOT deadenylase complex safeguards thymic positive selection by down-regulating aberrant pro-apoptotic gene expression |
| title_fullStr |
The CCR4–NOT deadenylase complex safeguards thymic positive selection by down-regulating aberrant pro-apoptotic gene expression |
| title_full_unstemmed |
The CCR4–NOT deadenylase complex safeguards thymic positive selection by down-regulating aberrant pro-apoptotic gene expression |
| title_sort |
ccr4–not deadenylase complex safeguards thymic positive selection by down-regulating aberrant pro-apoptotic gene expression |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/e8632bde18164a9fa0e055cc88ae0bea |
| work_keys_str_mv |
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