N-GSDMD trafficking to neutrophil organelles facilitates IL-1β release independently of plasma membrane pores and pyroptosis

In macrophages, IL-1β secretion is mediated by N-GSDMD pores in the plasma membrane (PM). Here the authors show that in neutrophils, IL-1β secretion occurs in the absence of PM pores, via autophagosomes; N-GSDMD does not traffic to PM but to azurophilic granules, thereby releasing neutrophil elastas...

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Autores principales:	Mausita Karmakar, Martin Minns, Elyse N. Greenberg, Jose Diaz-Aponte, Kersi Pestonjamasp, Jennifer L. Johnson, Joseph K. Rathkey, Derek W. Abbott, Kun Wang, Feng Shao, Sergio D. Catz, George R. Dubyak, Eric Pearlman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e8657a099f0941af8558ca645f8e6b29
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spelling	oai:doaj.org-article:e8657a099f0941af8558ca645f8e6b292021-12-02T17:32:58ZN-GSDMD trafficking to neutrophil organelles facilitates IL-1β release independently of plasma membrane pores and pyroptosis10.1038/s41467-020-16043-92041-1723https://doaj.org/article/e8657a099f0941af8558ca645f8e6b292020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16043-9https://doaj.org/toc/2041-1723In macrophages, IL-1β secretion is mediated by N-GSDMD pores in the plasma membrane (PM). Here the authors show that in neutrophils, IL-1β secretion occurs in the absence of PM pores, via autophagosomes; N-GSDMD does not traffic to PM but to azurophilic granules, thereby releasing neutrophil elastase which cleaves further N-GSDMD into alternative fragments.Mausita KarmakarMartin MinnsElyse N. GreenbergJose Diaz-AponteKersi PestonjamaspJennifer L. JohnsonJoseph K. RathkeyDerek W. AbbottKun WangFeng ShaoSergio D. CatzGeorge R. DubyakEric PearlmanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mausita Karmakar Martin Minns Elyse N. Greenberg Jose Diaz-Aponte Kersi Pestonjamasp Jennifer L. Johnson Joseph K. Rathkey Derek W. Abbott Kun Wang Feng Shao Sergio D. Catz George R. Dubyak Eric Pearlman N-GSDMD trafficking to neutrophil organelles facilitates IL-1β release independently of plasma membrane pores and pyroptosis
description	In macrophages, IL-1β secretion is mediated by N-GSDMD pores in the plasma membrane (PM). Here the authors show that in neutrophils, IL-1β secretion occurs in the absence of PM pores, via autophagosomes; N-GSDMD does not traffic to PM but to azurophilic granules, thereby releasing neutrophil elastase which cleaves further N-GSDMD into alternative fragments.
format	article
author	Mausita Karmakar Martin Minns Elyse N. Greenberg Jose Diaz-Aponte Kersi Pestonjamasp Jennifer L. Johnson Joseph K. Rathkey Derek W. Abbott Kun Wang Feng Shao Sergio D. Catz George R. Dubyak Eric Pearlman
author_facet	Mausita Karmakar Martin Minns Elyse N. Greenberg Jose Diaz-Aponte Kersi Pestonjamasp Jennifer L. Johnson Joseph K. Rathkey Derek W. Abbott Kun Wang Feng Shao Sergio D. Catz George R. Dubyak Eric Pearlman
author_sort	Mausita Karmakar
title	N-GSDMD trafficking to neutrophil organelles facilitates IL-1β release independently of plasma membrane pores and pyroptosis
title_short	N-GSDMD trafficking to neutrophil organelles facilitates IL-1β release independently of plasma membrane pores and pyroptosis
title_full	N-GSDMD trafficking to neutrophil organelles facilitates IL-1β release independently of plasma membrane pores and pyroptosis
title_fullStr	N-GSDMD trafficking to neutrophil organelles facilitates IL-1β release independently of plasma membrane pores and pyroptosis
title_full_unstemmed	N-GSDMD trafficking to neutrophil organelles facilitates IL-1β release independently of plasma membrane pores and pyroptosis
title_sort	n-gsdmd trafficking to neutrophil organelles facilitates il-1β release independently of plasma membrane pores and pyroptosis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e8657a099f0941af8558ca645f8e6b29
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N-GSDMD trafficking to neutrophil organelles facilitates IL-1β release independently of plasma membrane pores and pyroptosis

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