Prognostic Nomogram for Overall Survival of Patients Aged 50 Years or Older with Cervical Cancer

Jing Yan,1,2 Yue He,1 Ming Wang,1 Yumei Wu1 1Department of Gynecological Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University; Beijing Maternal and Child Health Care Hospital, Beijing, People’s Republic of China; 2Department of Gynecology, Fuxing Hospital, Capital Medical...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yan J, He Y, Wang M, Wu Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	prognosis nomogram cervical cancer surveillance epidemiology and end results (seer) Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/e86a2c92c824477f88fe6aeced5b0cd1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e86a2c92c824477f88fe6aeced5b0cd1
record_format	dspace
spelling	oai:doaj.org-article:e86a2c92c824477f88fe6aeced5b0cd12021-11-07T18:42:56ZPrognostic Nomogram for Overall Survival of Patients Aged 50 Years or Older with Cervical Cancer1178-7074https://doaj.org/article/e86a2c92c824477f88fe6aeced5b0cd12021-11-01T00:00:00Zhttps://www.dovepress.com/prognostic-nomogram-for-overall-survival-of-patients-aged-50-years-or--peer-reviewed-fulltext-article-IJGMhttps://doaj.org/toc/1178-7074Jing Yan,1,2 Yue He,1 Ming Wang,1 Yumei Wu1 1Department of Gynecological Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University; Beijing Maternal and Child Health Care Hospital, Beijing, People’s Republic of China; 2Department of Gynecology, Fuxing Hospital, Capital Medical University, Beijing, People’s Republic of ChinaCorrespondence: Yumei WuDepartment of Gynecological Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University; Beijing Maternal and Child Health Care Hospital, Dongcheng District, Qi-He-Lou Street No. 17, Beijing, People’s Republic of ChinaEmail wym597118@ccmu.edu.cnObjective: The prognostic factors of cervical cancer in elderly patients have not been researched systematically. We aimed to investigate the clinicopathological characteristics of patients with cervical cancer aged ≥ 50 years and establish a nomogram for evaluating their prognoses for overall survival.Methods: From the Surveillance, Epidemiology, and End Results database, we obtained data of 8538 patients with pathology-confirmed cervical cancer between 2004 and 2015. Patients were divided into training (n = 5941) and validation (n = 2597) cohorts. A nomogram was constructed to evaluate the prognostic prediction value for disease progression. The concordance index, receiver operating characteristic curve, and calibration chart were used to evaluate the model’s prediction accuracy and discriminative ability. Survival condition was analyzed using the Kaplan–Meier method.Results: In the training cohort, age at diagnosis, race, histology, grade, stage, tumor size, number of examined lymph nodes, and treatment significantly correlated with outcome and were used to develop the nomogram. The calibration curve for survival probability showed an excellent agreement between the nomogram-predicted and actual survival in the training cohort.Conclusion: Our nomogram has less bias and gives better accuracy than the International Federation of Gynecology and Obstetrics staging system and can help set up a more individualized feasible follow-up plan.Keywords: prognosis, nomogram, cervical cancer, Surveillance, Epidemiology and End Results, SEERYan JHe YWang MWu YDove Medical Pressarticleprognosisnomogramcervical cancersurveillanceepidemiology and end results (seer)Medicine (General)R5-920ENInternational Journal of General Medicine, Vol Volume 14, Pp 7741-7754 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	prognosis nomogram cervical cancer surveillance epidemiology and end results (seer) Medicine (General) R5-920
spellingShingle	prognosis nomogram cervical cancer surveillance epidemiology and end results (seer) Medicine (General) R5-920 Yan J He Y Wang M Wu Y Prognostic Nomogram for Overall Survival of Patients Aged 50 Years or Older with Cervical Cancer
description	Jing Yan,1,2 Yue He,1 Ming Wang,1 Yumei Wu1 1Department of Gynecological Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University; Beijing Maternal and Child Health Care Hospital, Beijing, People’s Republic of China; 2Department of Gynecology, Fuxing Hospital, Capital Medical University, Beijing, People’s Republic of ChinaCorrespondence: Yumei WuDepartment of Gynecological Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University; Beijing Maternal and Child Health Care Hospital, Dongcheng District, Qi-He-Lou Street No. 17, Beijing, People’s Republic of ChinaEmail wym597118@ccmu.edu.cnObjective: The prognostic factors of cervical cancer in elderly patients have not been researched systematically. We aimed to investigate the clinicopathological characteristics of patients with cervical cancer aged ≥ 50 years and establish a nomogram for evaluating their prognoses for overall survival.Methods: From the Surveillance, Epidemiology, and End Results database, we obtained data of 8538 patients with pathology-confirmed cervical cancer between 2004 and 2015. Patients were divided into training (n = 5941) and validation (n = 2597) cohorts. A nomogram was constructed to evaluate the prognostic prediction value for disease progression. The concordance index, receiver operating characteristic curve, and calibration chart were used to evaluate the model’s prediction accuracy and discriminative ability. Survival condition was analyzed using the Kaplan–Meier method.Results: In the training cohort, age at diagnosis, race, histology, grade, stage, tumor size, number of examined lymph nodes, and treatment significantly correlated with outcome and were used to develop the nomogram. The calibration curve for survival probability showed an excellent agreement between the nomogram-predicted and actual survival in the training cohort.Conclusion: Our nomogram has less bias and gives better accuracy than the International Federation of Gynecology and Obstetrics staging system and can help set up a more individualized feasible follow-up plan.Keywords: prognosis, nomogram, cervical cancer, Surveillance, Epidemiology and End Results, SEER
format	article
author	Yan J He Y Wang M Wu Y
author_facet	Yan J He Y Wang M Wu Y
author_sort	Yan J
title	Prognostic Nomogram for Overall Survival of Patients Aged 50 Years or Older with Cervical Cancer
title_short	Prognostic Nomogram for Overall Survival of Patients Aged 50 Years or Older with Cervical Cancer
title_full	Prognostic Nomogram for Overall Survival of Patients Aged 50 Years or Older with Cervical Cancer
title_fullStr	Prognostic Nomogram for Overall Survival of Patients Aged 50 Years or Older with Cervical Cancer
title_full_unstemmed	Prognostic Nomogram for Overall Survival of Patients Aged 50 Years or Older with Cervical Cancer
title_sort	prognostic nomogram for overall survival of patients aged 50 years or older with cervical cancer
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/e86a2c92c824477f88fe6aeced5b0cd1
work_keys_str_mv	AT yanj prognosticnomogramforoverallsurvivalofpatientsaged50yearsorolderwithcervicalcancer AT hey prognosticnomogramforoverallsurvivalofpatientsaged50yearsorolderwithcervicalcancer AT wangm prognosticnomogramforoverallsurvivalofpatientsaged50yearsorolderwithcervicalcancer AT wuy prognosticnomogramforoverallsurvivalofpatientsaged50yearsorolderwithcervicalcancer
_version_	1718443321999753216

Prognostic Nomogram for Overall Survival of Patients Aged 50 Years or Older with Cervical Cancer

Ejemplares similares