Single nucleus RNA-sequencing defines unexpected diversity of cholinergic neuron types in the adult mouse spinal cord
The full heterogeneity and different functional roles of cholinergic neurons in the adult spinal cord remain to be defined. Here the authors develop a targeted single nuclear RNA sequencing approach and use it to identify an array of cholinergic interneurons, as well as visceral and skeletal motor n...
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Nature Portfolio
2021
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oai:doaj.org-article:e86a5e80b2b44fef8231c3f0277a9d1f2021-12-02T13:41:32ZSingle nucleus RNA-sequencing defines unexpected diversity of cholinergic neuron types in the adult mouse spinal cord10.1038/s41467-021-22691-22041-1723https://doaj.org/article/e86a5e80b2b44fef8231c3f0277a9d1f2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22691-2https://doaj.org/toc/2041-1723The full heterogeneity and different functional roles of cholinergic neurons in the adult spinal cord remain to be defined. Here the authors develop a targeted single nuclear RNA sequencing approach and use it to identify an array of cholinergic interneurons, as well as visceral and skeletal motor neurons.Mor R. AlkaslasiZoe E. PiccusSangeetha HareendranHanna SilberbergLi ChenYajun ZhangTimothy J. PetrosClaire E. Le PichonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021) |
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Science Q Mor R. Alkaslasi Zoe E. Piccus Sangeetha Hareendran Hanna Silberberg Li Chen Yajun Zhang Timothy J. Petros Claire E. Le Pichon Single nucleus RNA-sequencing defines unexpected diversity of cholinergic neuron types in the adult mouse spinal cord |
description |
The full heterogeneity and different functional roles of cholinergic neurons in the adult spinal cord remain to be defined. Here the authors develop a targeted single nuclear RNA sequencing approach and use it to identify an array of cholinergic interneurons, as well as visceral and skeletal motor neurons. |
format |
article |
author |
Mor R. Alkaslasi Zoe E. Piccus Sangeetha Hareendran Hanna Silberberg Li Chen Yajun Zhang Timothy J. Petros Claire E. Le Pichon |
author_facet |
Mor R. Alkaslasi Zoe E. Piccus Sangeetha Hareendran Hanna Silberberg Li Chen Yajun Zhang Timothy J. Petros Claire E. Le Pichon |
author_sort |
Mor R. Alkaslasi |
title |
Single nucleus RNA-sequencing defines unexpected diversity of cholinergic neuron types in the adult mouse spinal cord |
title_short |
Single nucleus RNA-sequencing defines unexpected diversity of cholinergic neuron types in the adult mouse spinal cord |
title_full |
Single nucleus RNA-sequencing defines unexpected diversity of cholinergic neuron types in the adult mouse spinal cord |
title_fullStr |
Single nucleus RNA-sequencing defines unexpected diversity of cholinergic neuron types in the adult mouse spinal cord |
title_full_unstemmed |
Single nucleus RNA-sequencing defines unexpected diversity of cholinergic neuron types in the adult mouse spinal cord |
title_sort |
single nucleus rna-sequencing defines unexpected diversity of cholinergic neuron types in the adult mouse spinal cord |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/e86a5e80b2b44fef8231c3f0277a9d1f |
work_keys_str_mv |
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