Single nucleus RNA-sequencing defines unexpected diversity of cholinergic neuron types in the adult mouse spinal cord

The full heterogeneity and different functional roles of cholinergic neurons in the adult spinal cord remain to be defined. Here the authors develop a targeted single nuclear RNA sequencing approach and use it to identify an array of cholinergic interneurons, as well as visceral and skeletal motor n...

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Autores principales: Mor R. Alkaslasi, Zoe E. Piccus, Sangeetha Hareendran, Hanna Silberberg, Li Chen, Yajun Zhang, Timothy J. Petros, Claire E. Le Pichon
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/e86a5e80b2b44fef8231c3f0277a9d1f
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spelling oai:doaj.org-article:e86a5e80b2b44fef8231c3f0277a9d1f2021-12-02T13:41:32ZSingle nucleus RNA-sequencing defines unexpected diversity of cholinergic neuron types in the adult mouse spinal cord10.1038/s41467-021-22691-22041-1723https://doaj.org/article/e86a5e80b2b44fef8231c3f0277a9d1f2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22691-2https://doaj.org/toc/2041-1723The full heterogeneity and different functional roles of cholinergic neurons in the adult spinal cord remain to be defined. Here the authors develop a targeted single nuclear RNA sequencing approach and use it to identify an array of cholinergic interneurons, as well as visceral and skeletal motor neurons.Mor R. AlkaslasiZoe E. PiccusSangeetha HareendranHanna SilberbergLi ChenYajun ZhangTimothy J. PetrosClaire E. Le PichonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Mor R. Alkaslasi
Zoe E. Piccus
Sangeetha Hareendran
Hanna Silberberg
Li Chen
Yajun Zhang
Timothy J. Petros
Claire E. Le Pichon
Single nucleus RNA-sequencing defines unexpected diversity of cholinergic neuron types in the adult mouse spinal cord
description The full heterogeneity and different functional roles of cholinergic neurons in the adult spinal cord remain to be defined. Here the authors develop a targeted single nuclear RNA sequencing approach and use it to identify an array of cholinergic interneurons, as well as visceral and skeletal motor neurons.
format article
author Mor R. Alkaslasi
Zoe E. Piccus
Sangeetha Hareendran
Hanna Silberberg
Li Chen
Yajun Zhang
Timothy J. Petros
Claire E. Le Pichon
author_facet Mor R. Alkaslasi
Zoe E. Piccus
Sangeetha Hareendran
Hanna Silberberg
Li Chen
Yajun Zhang
Timothy J. Petros
Claire E. Le Pichon
author_sort Mor R. Alkaslasi
title Single nucleus RNA-sequencing defines unexpected diversity of cholinergic neuron types in the adult mouse spinal cord
title_short Single nucleus RNA-sequencing defines unexpected diversity of cholinergic neuron types in the adult mouse spinal cord
title_full Single nucleus RNA-sequencing defines unexpected diversity of cholinergic neuron types in the adult mouse spinal cord
title_fullStr Single nucleus RNA-sequencing defines unexpected diversity of cholinergic neuron types in the adult mouse spinal cord
title_full_unstemmed Single nucleus RNA-sequencing defines unexpected diversity of cholinergic neuron types in the adult mouse spinal cord
title_sort single nucleus rna-sequencing defines unexpected diversity of cholinergic neuron types in the adult mouse spinal cord
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/e86a5e80b2b44fef8231c3f0277a9d1f
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