Distinct systemic cytokine networks in symptomatic and asymptomatic carotid stenosis

Abstract Inflammatory processes are crucial in atherosclerosis and atherothrombosis. This study aimed to identify a cytokine-pattern that is associated with plaque-vulnerability or symptomatic state in comprehensively investigated patients with symptomatic (sCS) and asymptomatic carotid stenosis (aC...

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Autores principales:	Ricarda D. Stauss, Gerrit M. Grosse, Lavinia Neubert, Christine S. Falk, Danny Jonigk, Mark P. Kühnel, Maria M. Gabriel, Ramona Schuppner, Ralf Lichtinghagen, Mathias Wilhelmi, Karin Weissenborn, Claudia Schrimpf
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e86abe80c712479098f5bd5ac2b901d5
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spelling	oai:doaj.org-article:e86abe80c712479098f5bd5ac2b901d52021-12-02T12:40:41ZDistinct systemic cytokine networks in symptomatic and asymptomatic carotid stenosis10.1038/s41598-020-78941-82045-2322https://doaj.org/article/e86abe80c712479098f5bd5ac2b901d52020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78941-8https://doaj.org/toc/2045-2322Abstract Inflammatory processes are crucial in atherosclerosis and atherothrombosis. This study aimed to identify a cytokine-pattern that is associated with plaque-vulnerability or symptomatic state in comprehensively investigated patients with symptomatic (sCS) and asymptomatic carotid stenosis (aCS). Twenty-two patients with sCS and twenty-four patients with aCS undergoing carotid endarterectomy (CEA) were considered. A cytokine-panel was measured in plasma-specimens prior to surgery and at a 90 day follow-up. Doppler-ultrasound detecting microembolic signals (MES) in the ipsilateral middle cerebral artery was performed. Carotid plaques were analysed regarding histopathological criteria of plaque-vulnerability and presence of chemokine receptor CXCR4. Correction for multiple comparisons and logistic regression analysis adjusting for vascular risk factors, grade of stenosis, antithrombotic and statin pretreatment were applied. In sCS-patients higher plasma-levels of Fractalkine (CX3CL1), IFN-α2, IL-1β, IL-2, IL-3, IL-7 were found compared to aCS-patients. CXCR4-expression on inflammatory cells was more evident in sCS- compared to aCS-plaques and was associated with vulnerability-criteria. In contrast, plasma-cytokine-levels were not related to CXCR4-expression or other vulnerability-criteria or MES. However, in both groups distinct inter-cytokine correlation patterns, which persisted at follow-up and were more pronounced in the sCS-group could be detected. In conclusion, we identified a distinct cytokine/chemokine-network in sCS-patients with elevated and closely correlated mediators of diverse functions.Ricarda D. StaussGerrit M. GrosseLavinia NeubertChristine S. FalkDanny JonigkMark P. KühnelMaria M. GabrielRamona SchuppnerRalf LichtinghagenMathias WilhelmiKarin WeissenbornClaudia SchrimpfNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ricarda D. Stauss Gerrit M. Grosse Lavinia Neubert Christine S. Falk Danny Jonigk Mark P. Kühnel Maria M. Gabriel Ramona Schuppner Ralf Lichtinghagen Mathias Wilhelmi Karin Weissenborn Claudia Schrimpf Distinct systemic cytokine networks in symptomatic and asymptomatic carotid stenosis
description	Abstract Inflammatory processes are crucial in atherosclerosis and atherothrombosis. This study aimed to identify a cytokine-pattern that is associated with plaque-vulnerability or symptomatic state in comprehensively investigated patients with symptomatic (sCS) and asymptomatic carotid stenosis (aCS). Twenty-two patients with sCS and twenty-four patients with aCS undergoing carotid endarterectomy (CEA) were considered. A cytokine-panel was measured in plasma-specimens prior to surgery and at a 90 day follow-up. Doppler-ultrasound detecting microembolic signals (MES) in the ipsilateral middle cerebral artery was performed. Carotid plaques were analysed regarding histopathological criteria of plaque-vulnerability and presence of chemokine receptor CXCR4. Correction for multiple comparisons and logistic regression analysis adjusting for vascular risk factors, grade of stenosis, antithrombotic and statin pretreatment were applied. In sCS-patients higher plasma-levels of Fractalkine (CX3CL1), IFN-α2, IL-1β, IL-2, IL-3, IL-7 were found compared to aCS-patients. CXCR4-expression on inflammatory cells was more evident in sCS- compared to aCS-plaques and was associated with vulnerability-criteria. In contrast, plasma-cytokine-levels were not related to CXCR4-expression or other vulnerability-criteria or MES. However, in both groups distinct inter-cytokine correlation patterns, which persisted at follow-up and were more pronounced in the sCS-group could be detected. In conclusion, we identified a distinct cytokine/chemokine-network in sCS-patients with elevated and closely correlated mediators of diverse functions.
format	article
author	Ricarda D. Stauss Gerrit M. Grosse Lavinia Neubert Christine S. Falk Danny Jonigk Mark P. Kühnel Maria M. Gabriel Ramona Schuppner Ralf Lichtinghagen Mathias Wilhelmi Karin Weissenborn Claudia Schrimpf
author_facet	Ricarda D. Stauss Gerrit M. Grosse Lavinia Neubert Christine S. Falk Danny Jonigk Mark P. Kühnel Maria M. Gabriel Ramona Schuppner Ralf Lichtinghagen Mathias Wilhelmi Karin Weissenborn Claudia Schrimpf
author_sort	Ricarda D. Stauss
title	Distinct systemic cytokine networks in symptomatic and asymptomatic carotid stenosis
title_short	Distinct systemic cytokine networks in symptomatic and asymptomatic carotid stenosis
title_full	Distinct systemic cytokine networks in symptomatic and asymptomatic carotid stenosis
title_fullStr	Distinct systemic cytokine networks in symptomatic and asymptomatic carotid stenosis
title_full_unstemmed	Distinct systemic cytokine networks in symptomatic and asymptomatic carotid stenosis
title_sort	distinct systemic cytokine networks in symptomatic and asymptomatic carotid stenosis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e86abe80c712479098f5bd5ac2b901d5
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Distinct systemic cytokine networks in symptomatic and asymptomatic carotid stenosis

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