A portable pen-sized instrumentation to measure stiffness of soft tissues in vivo

Abstract Quantitative assessment of soft tissue elasticity is crucial to a broad range of applications, such as biomechanical modeling, physiological monitoring, and tissue diseases diagnosing. However, the modulus measurement of soft tissues, particularly in vivo, has proved challenging since the i...

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Autores principales: Zhengwei Li, Alireza Tofangchi, Robert A. Stavins, Bashar Emon, Ronald D. McKinney, Paul J. Grippo, M. Taher A. Saif
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Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/e87253a11a7f4e5db0f5ef2f88b9dea6
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spelling oai:doaj.org-article:e87253a11a7f4e5db0f5ef2f88b9dea62021-12-02T14:12:46ZA portable pen-sized instrumentation to measure stiffness of soft tissues in vivo10.1038/s41598-020-79735-82045-2322https://doaj.org/article/e87253a11a7f4e5db0f5ef2f88b9dea62021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79735-8https://doaj.org/toc/2045-2322Abstract Quantitative assessment of soft tissue elasticity is crucial to a broad range of applications, such as biomechanical modeling, physiological monitoring, and tissue diseases diagnosing. However, the modulus measurement of soft tissues, particularly in vivo, has proved challenging since the instrument has to reach the site of soft tissue and be able to measure in a very short time. Here, we present a simple method to measure the elastic modulus of soft tissues on site by exploiting buckling of a long slender bar to quantify the applied force and a spherical indentation to extract the elastic modulus. The method is realized by developing a portable pen-sized instrument (EPen: Elastic modulus pen). The measurement accuracies are verified by independent modulus measures using commercial nanoindenter. Quantitative measurements of the elastic modulus of mouse pancreas, healthy and cancerous, surgically exposed but attached to the body further confirm the potential clinical utility of the EPen.Zhengwei LiAlireza TofangchiRobert A. StavinsBashar EmonRonald D. McKinneyPaul J. GrippoM. Taher A. SaifNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Zhengwei Li
Alireza Tofangchi
Robert A. Stavins
Bashar Emon
Ronald D. McKinney
Paul J. Grippo
M. Taher A. Saif
A portable pen-sized instrumentation to measure stiffness of soft tissues in vivo
description Abstract Quantitative assessment of soft tissue elasticity is crucial to a broad range of applications, such as biomechanical modeling, physiological monitoring, and tissue diseases diagnosing. However, the modulus measurement of soft tissues, particularly in vivo, has proved challenging since the instrument has to reach the site of soft tissue and be able to measure in a very short time. Here, we present a simple method to measure the elastic modulus of soft tissues on site by exploiting buckling of a long slender bar to quantify the applied force and a spherical indentation to extract the elastic modulus. The method is realized by developing a portable pen-sized instrument (EPen: Elastic modulus pen). The measurement accuracies are verified by independent modulus measures using commercial nanoindenter. Quantitative measurements of the elastic modulus of mouse pancreas, healthy and cancerous, surgically exposed but attached to the body further confirm the potential clinical utility of the EPen.
format article
author Zhengwei Li
Alireza Tofangchi
Robert A. Stavins
Bashar Emon
Ronald D. McKinney
Paul J. Grippo
M. Taher A. Saif
author_facet Zhengwei Li
Alireza Tofangchi
Robert A. Stavins
Bashar Emon
Ronald D. McKinney
Paul J. Grippo
M. Taher A. Saif
author_sort Zhengwei Li
title A portable pen-sized instrumentation to measure stiffness of soft tissues in vivo
title_short A portable pen-sized instrumentation to measure stiffness of soft tissues in vivo
title_full A portable pen-sized instrumentation to measure stiffness of soft tissues in vivo
title_fullStr A portable pen-sized instrumentation to measure stiffness of soft tissues in vivo
title_full_unstemmed A portable pen-sized instrumentation to measure stiffness of soft tissues in vivo
title_sort portable pen-sized instrumentation to measure stiffness of soft tissues in vivo
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/e87253a11a7f4e5db0f5ef2f88b9dea6
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