A portable pen-sized instrumentation to measure stiffness of soft tissues in vivo

Abstract Quantitative assessment of soft tissue elasticity is crucial to a broad range of applications, such as biomechanical modeling, physiological monitoring, and tissue diseases diagnosing. However, the modulus measurement of soft tissues, particularly in vivo, has proved challenging since the i...

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Auteurs principaux:	Zhengwei Li, Alireza Tofangchi, Robert A. Stavins, Bashar Emon, Ronald D. McKinney, Paul J. Grippo, M. Taher A. Saif
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Medicine R Science Q
Accès en ligne:	https://doaj.org/article/e87253a11a7f4e5db0f5ef2f88b9dea6
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id	oai:doaj.org-article:e87253a11a7f4e5db0f5ef2f88b9dea6
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spelling	oai:doaj.org-article:e87253a11a7f4e5db0f5ef2f88b9dea62021-12-02T14:12:46ZA portable pen-sized instrumentation to measure stiffness of soft tissues in vivo10.1038/s41598-020-79735-82045-2322https://doaj.org/article/e87253a11a7f4e5db0f5ef2f88b9dea62021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79735-8https://doaj.org/toc/2045-2322Abstract Quantitative assessment of soft tissue elasticity is crucial to a broad range of applications, such as biomechanical modeling, physiological monitoring, and tissue diseases diagnosing. However, the modulus measurement of soft tissues, particularly in vivo, has proved challenging since the instrument has to reach the site of soft tissue and be able to measure in a very short time. Here, we present a simple method to measure the elastic modulus of soft tissues on site by exploiting buckling of a long slender bar to quantify the applied force and a spherical indentation to extract the elastic modulus. The method is realized by developing a portable pen-sized instrument (EPen: Elastic modulus pen). The measurement accuracies are verified by independent modulus measures using commercial nanoindenter. Quantitative measurements of the elastic modulus of mouse pancreas, healthy and cancerous, surgically exposed but attached to the body further confirm the potential clinical utility of the EPen.Zhengwei LiAlireza TofangchiRobert A. StavinsBashar EmonRonald D. McKinneyPaul J. GrippoM. Taher A. SaifNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zhengwei Li Alireza Tofangchi Robert A. Stavins Bashar Emon Ronald D. McKinney Paul J. Grippo M. Taher A. Saif A portable pen-sized instrumentation to measure stiffness of soft tissues in vivo
description	Abstract Quantitative assessment of soft tissue elasticity is crucial to a broad range of applications, such as biomechanical modeling, physiological monitoring, and tissue diseases diagnosing. However, the modulus measurement of soft tissues, particularly in vivo, has proved challenging since the instrument has to reach the site of soft tissue and be able to measure in a very short time. Here, we present a simple method to measure the elastic modulus of soft tissues on site by exploiting buckling of a long slender bar to quantify the applied force and a spherical indentation to extract the elastic modulus. The method is realized by developing a portable pen-sized instrument (EPen: Elastic modulus pen). The measurement accuracies are verified by independent modulus measures using commercial nanoindenter. Quantitative measurements of the elastic modulus of mouse pancreas, healthy and cancerous, surgically exposed but attached to the body further confirm the potential clinical utility of the EPen.
format	article
author	Zhengwei Li Alireza Tofangchi Robert A. Stavins Bashar Emon Ronald D. McKinney Paul J. Grippo M. Taher A. Saif
author_facet	Zhengwei Li Alireza Tofangchi Robert A. Stavins Bashar Emon Ronald D. McKinney Paul J. Grippo M. Taher A. Saif
author_sort	Zhengwei Li
title	A portable pen-sized instrumentation to measure stiffness of soft tissues in vivo
title_short	A portable pen-sized instrumentation to measure stiffness of soft tissues in vivo
title_full	A portable pen-sized instrumentation to measure stiffness of soft tissues in vivo
title_fullStr	A portable pen-sized instrumentation to measure stiffness of soft tissues in vivo
title_full_unstemmed	A portable pen-sized instrumentation to measure stiffness of soft tissues in vivo
title_sort	portable pen-sized instrumentation to measure stiffness of soft tissues in vivo
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e87253a11a7f4e5db0f5ef2f88b9dea6
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A portable pen-sized instrumentation to measure stiffness of soft tissues in vivo

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