White blood cell and cell-free DNA analyses for detection of residual disease in gastric cancer

Identifying patients that will respond to a particular therapy remains a key challenge in precision oncology. Here, in gastric cancer, the authors show that circulating tumour DNA can predict recurrence, provided that the signal from white blood cells is filtered out.

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Autores principales:	Alessandro Leal, Nicole C. T. van Grieken, Doreen N. Palsgrove, Jillian Phallen, Jamie E. Medina, Carolyn Hruban, Mark A. M. Broeckaert, Valsamo Anagnostou, Vilmos Adleff, Daniel C. Bruhm, Jenna V. Canzoniero, Jacob Fiksel, Marianne Nordsmark, Fabienne A. R. M. Warmerdam, Henk M. W. Verheul, Dick Johan van Spronsen, Laurens V. Beerepoot, Maud M. Geenen, Johanneke E. A. Portielje, Edwin P. M. Jansen, Johanna van Sandick, Elma Meershoek-Klein Kranenbarg, Hanneke W. M. van Laarhoven, Donald L. van der Peet, Cornelis J. H. van de Velde, Marcel Verheij, Remond Fijneman, Robert B. Scharpf, Gerrit A. Meijer, Annemieke Cats, Victor E. Velculescu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e873283671f243d3ba192161c80d36a7
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spelling	oai:doaj.org-article:e873283671f243d3ba192161c80d36a72021-12-02T14:42:12ZWhite blood cell and cell-free DNA analyses for detection of residual disease in gastric cancer10.1038/s41467-020-14310-32041-1723https://doaj.org/article/e873283671f243d3ba192161c80d36a72020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14310-3https://doaj.org/toc/2041-1723Identifying patients that will respond to a particular therapy remains a key challenge in precision oncology. Here, in gastric cancer, the authors show that circulating tumour DNA can predict recurrence, provided that the signal from white blood cells is filtered out.Alessandro LealNicole C. T. van GriekenDoreen N. PalsgroveJillian PhallenJamie E. MedinaCarolyn HrubanMark A. M. BroeckaertValsamo AnagnostouVilmos AdleffDaniel C. BruhmJenna V. CanzonieroJacob FikselMarianne NordsmarkFabienne A. R. M. WarmerdamHenk M. W. VerheulDick Johan van SpronsenLaurens V. BeerepootMaud M. GeenenJohanneke E. A. PortieljeEdwin P. M. JansenJohanna van SandickElma Meershoek-Klein KranenbargHanneke W. M. van LaarhovenDonald L. van der PeetCornelis J. H. van de VeldeMarcel VerheijRemond FijnemanRobert B. ScharpfGerrit A. MeijerAnnemieke CatsVictor E. VelculescuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alessandro Leal Nicole C. T. van Grieken Doreen N. Palsgrove Jillian Phallen Jamie E. Medina Carolyn Hruban Mark A. M. Broeckaert Valsamo Anagnostou Vilmos Adleff Daniel C. Bruhm Jenna V. Canzoniero Jacob Fiksel Marianne Nordsmark Fabienne A. R. M. Warmerdam Henk M. W. Verheul Dick Johan van Spronsen Laurens V. Beerepoot Maud M. Geenen Johanneke E. A. Portielje Edwin P. M. Jansen Johanna van Sandick Elma Meershoek-Klein Kranenbarg Hanneke W. M. van Laarhoven Donald L. van der Peet Cornelis J. H. van de Velde Marcel Verheij Remond Fijneman Robert B. Scharpf Gerrit A. Meijer Annemieke Cats Victor E. Velculescu White blood cell and cell-free DNA analyses for detection of residual disease in gastric cancer
description	Identifying patients that will respond to a particular therapy remains a key challenge in precision oncology. Here, in gastric cancer, the authors show that circulating tumour DNA can predict recurrence, provided that the signal from white blood cells is filtered out.
format	article
author	Alessandro Leal Nicole C. T. van Grieken Doreen N. Palsgrove Jillian Phallen Jamie E. Medina Carolyn Hruban Mark A. M. Broeckaert Valsamo Anagnostou Vilmos Adleff Daniel C. Bruhm Jenna V. Canzoniero Jacob Fiksel Marianne Nordsmark Fabienne A. R. M. Warmerdam Henk M. W. Verheul Dick Johan van Spronsen Laurens V. Beerepoot Maud M. Geenen Johanneke E. A. Portielje Edwin P. M. Jansen Johanna van Sandick Elma Meershoek-Klein Kranenbarg Hanneke W. M. van Laarhoven Donald L. van der Peet Cornelis J. H. van de Velde Marcel Verheij Remond Fijneman Robert B. Scharpf Gerrit A. Meijer Annemieke Cats Victor E. Velculescu
author_facet	Alessandro Leal Nicole C. T. van Grieken Doreen N. Palsgrove Jillian Phallen Jamie E. Medina Carolyn Hruban Mark A. M. Broeckaert Valsamo Anagnostou Vilmos Adleff Daniel C. Bruhm Jenna V. Canzoniero Jacob Fiksel Marianne Nordsmark Fabienne A. R. M. Warmerdam Henk M. W. Verheul Dick Johan van Spronsen Laurens V. Beerepoot Maud M. Geenen Johanneke E. A. Portielje Edwin P. M. Jansen Johanna van Sandick Elma Meershoek-Klein Kranenbarg Hanneke W. M. van Laarhoven Donald L. van der Peet Cornelis J. H. van de Velde Marcel Verheij Remond Fijneman Robert B. Scharpf Gerrit A. Meijer Annemieke Cats Victor E. Velculescu
author_sort	Alessandro Leal
title	White blood cell and cell-free DNA analyses for detection of residual disease in gastric cancer
title_short	White blood cell and cell-free DNA analyses for detection of residual disease in gastric cancer
title_full	White blood cell and cell-free DNA analyses for detection of residual disease in gastric cancer
title_fullStr	White blood cell and cell-free DNA analyses for detection of residual disease in gastric cancer
title_full_unstemmed	White blood cell and cell-free DNA analyses for detection of residual disease in gastric cancer
title_sort	white blood cell and cell-free dna analyses for detection of residual disease in gastric cancer
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e873283671f243d3ba192161c80d36a7
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White blood cell and cell-free DNA analyses for detection of residual disease in gastric cancer

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