Recurrent rearrangements of FOS and FOSB define osteoblastoma

FOS has been linked to bone tumour pathogenesis, and viral homologue v-fos causes osteosarcoma in mice. Here, the authors report rearrangement of FOS and its paralogue FOSB in osteoblastoma and osteoid osteoma, revealing human bone tumours that are defined by mutations of FOS and FOSB.

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Autores principales:	Matthew W. Fittall, William Mifsud, Nischalan Pillay, Hongtao Ye, Anna-Christina Strobl, Annelien Verfaillie, Jonas Demeulemeester, Lei Zhang, Fitim Berisha, Maxime Tarabichi, Matthew D. Young, Elena Miranda, Patrick S. Tarpey, Roberto Tirabosco, Fernanda Amary, Agamemnon E. Grigoriadis, Michael R. Stratton, Peter Van Loo, Cristina R. Antonescu, Peter J. Campbell, Adrienne M. Flanagan, Sam Behjati
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e874f5cac91c4dfcb8f739743873d777
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:e874f5cac91c4dfcb8f739743873d7772021-12-02T15:34:39ZRecurrent rearrangements of FOS and FOSB define osteoblastoma10.1038/s41467-018-04530-z2041-1723https://doaj.org/article/e874f5cac91c4dfcb8f739743873d7772018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04530-zhttps://doaj.org/toc/2041-1723FOS has been linked to bone tumour pathogenesis, and viral homologue v-fos causes osteosarcoma in mice. Here, the authors report rearrangement of FOS and its paralogue FOSB in osteoblastoma and osteoid osteoma, revealing human bone tumours that are defined by mutations of FOS and FOSB.Matthew W. FittallWilliam MifsudNischalan PillayHongtao YeAnna-Christina StroblAnnelien VerfaillieJonas DemeulemeesterLei ZhangFitim BerishaMaxime TarabichiMatthew D. YoungElena MirandaPatrick S. TarpeyRoberto TiraboscoFernanda AmaryAgamemnon E. GrigoriadisMichael R. StrattonPeter Van LooCristina R. AntonescuPeter J. CampbellAdrienne M. FlanaganSam BehjatiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-6 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Matthew W. Fittall William Mifsud Nischalan Pillay Hongtao Ye Anna-Christina Strobl Annelien Verfaillie Jonas Demeulemeester Lei Zhang Fitim Berisha Maxime Tarabichi Matthew D. Young Elena Miranda Patrick S. Tarpey Roberto Tirabosco Fernanda Amary Agamemnon E. Grigoriadis Michael R. Stratton Peter Van Loo Cristina R. Antonescu Peter J. Campbell Adrienne M. Flanagan Sam Behjati Recurrent rearrangements of FOS and FOSB define osteoblastoma
description	FOS has been linked to bone tumour pathogenesis, and viral homologue v-fos causes osteosarcoma in mice. Here, the authors report rearrangement of FOS and its paralogue FOSB in osteoblastoma and osteoid osteoma, revealing human bone tumours that are defined by mutations of FOS and FOSB.
format	article
author	Matthew W. Fittall William Mifsud Nischalan Pillay Hongtao Ye Anna-Christina Strobl Annelien Verfaillie Jonas Demeulemeester Lei Zhang Fitim Berisha Maxime Tarabichi Matthew D. Young Elena Miranda Patrick S. Tarpey Roberto Tirabosco Fernanda Amary Agamemnon E. Grigoriadis Michael R. Stratton Peter Van Loo Cristina R. Antonescu Peter J. Campbell Adrienne M. Flanagan Sam Behjati
author_facet	Matthew W. Fittall William Mifsud Nischalan Pillay Hongtao Ye Anna-Christina Strobl Annelien Verfaillie Jonas Demeulemeester Lei Zhang Fitim Berisha Maxime Tarabichi Matthew D. Young Elena Miranda Patrick S. Tarpey Roberto Tirabosco Fernanda Amary Agamemnon E. Grigoriadis Michael R. Stratton Peter Van Loo Cristina R. Antonescu Peter J. Campbell Adrienne M. Flanagan Sam Behjati
author_sort	Matthew W. Fittall
title	Recurrent rearrangements of FOS and FOSB define osteoblastoma
title_short	Recurrent rearrangements of FOS and FOSB define osteoblastoma
title_full	Recurrent rearrangements of FOS and FOSB define osteoblastoma
title_fullStr	Recurrent rearrangements of FOS and FOSB define osteoblastoma
title_full_unstemmed	Recurrent rearrangements of FOS and FOSB define osteoblastoma
title_sort	recurrent rearrangements of fos and fosb define osteoblastoma
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e874f5cac91c4dfcb8f739743873d777
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Recurrent rearrangements of FOS and FOSB define osteoblastoma

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