Anti-Multiple Myeloma Potential of Secondary Metabolites from <i>Hibiscus sabdariffa</i>—Part 2

Multiple Myeloma (MM) is an aggressive tumor causing millions of deaths every year and currently available therapies are often unsuccessful or correlated with severe side effects. In our previous work we demonstrated that the <i>Hibiscus sabdariffa</i> hydroalcoholic extract inhibits the...

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Autores principales: Alessio Malacrida, Valeria Cavalloro, Emanuela Martino, Giosuè Costa, Francesca Alessandra Ambrosio, Stefano Alcaro, Roberta Rigolio, Arianna Cassetti, Mariarosaria Miloso, Simona Collina
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Publicado: MDPI AG 2021
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Acceso en línea:https://doaj.org/article/e877108583c84a6291c723ade6122757
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spelling oai:doaj.org-article:e877108583c84a6291c723ade61227572021-11-11T18:34:22ZAnti-Multiple Myeloma Potential of Secondary Metabolites from <i>Hibiscus sabdariffa</i>—Part 210.3390/molecules262165961420-3049https://doaj.org/article/e877108583c84a6291c723ade61227572021-10-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/21/6596https://doaj.org/toc/1420-3049Multiple Myeloma (MM) is an aggressive tumor causing millions of deaths every year and currently available therapies are often unsuccessful or correlated with severe side effects. In our previous work we demonstrated that the <i>Hibiscus sabdariffa</i> hydroalcoholic extract inhibits the growth of the MM cell line and we isolated two metabolites responsible for the activity: <i>Hib-ester</i> and <i>Hib-carbaldehyde</i>. Herein we report their interaction with proteasome, one of the main targets in the fight against MM. The molecular modelling study outlined a good interaction of both compounds with the target and these results prompted us to investigate their potential to inhibit proteasome. Metabolites were then isolated from the calyces and an extract with a high content of <i>Hib-ester</i> and <i>Hib-carbaldehyde</i> was prepared. An anticancer profile was drawn, evaluating apoptosis, autophagy and proteasome inhibition, with the anticancer properties being mainly attributed to the <i>Hib-ester</i> and <i>Hib-carbaldehyde</i>, while the proteasome inhibition of the extract could also be ascribed to the presence of anthocyanins, a class of secondary metabolites already known for their proteasome inhibitory activity.Alessio MalacridaValeria CavalloroEmanuela MartinoGiosuè CostaFrancesca Alessandra AmbrosioStefano AlcaroRoberta RigolioArianna CassettiMariarosaria MilosoSimona CollinaMDPI AGarticle<i>Hibiscus sabdariffa</i><i>Hib-ester</i><i>Hib-carbaldehyde</i>anthocyaninsproteasomemultiple myelomaOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6596, p 6596 (2021)
institution DOAJ
collection DOAJ
language EN
topic <i>Hibiscus sabdariffa</i>
<i>Hib-ester</i>
<i>Hib-carbaldehyde</i>
anthocyanins
proteasome
multiple myeloma
Organic chemistry
QD241-441
spellingShingle <i>Hibiscus sabdariffa</i>
<i>Hib-ester</i>
<i>Hib-carbaldehyde</i>
anthocyanins
proteasome
multiple myeloma
Organic chemistry
QD241-441
Alessio Malacrida
Valeria Cavalloro
Emanuela Martino
Giosuè Costa
Francesca Alessandra Ambrosio
Stefano Alcaro
Roberta Rigolio
Arianna Cassetti
Mariarosaria Miloso
Simona Collina
Anti-Multiple Myeloma Potential of Secondary Metabolites from <i>Hibiscus sabdariffa</i>—Part 2
description Multiple Myeloma (MM) is an aggressive tumor causing millions of deaths every year and currently available therapies are often unsuccessful or correlated with severe side effects. In our previous work we demonstrated that the <i>Hibiscus sabdariffa</i> hydroalcoholic extract inhibits the growth of the MM cell line and we isolated two metabolites responsible for the activity: <i>Hib-ester</i> and <i>Hib-carbaldehyde</i>. Herein we report their interaction with proteasome, one of the main targets in the fight against MM. The molecular modelling study outlined a good interaction of both compounds with the target and these results prompted us to investigate their potential to inhibit proteasome. Metabolites were then isolated from the calyces and an extract with a high content of <i>Hib-ester</i> and <i>Hib-carbaldehyde</i> was prepared. An anticancer profile was drawn, evaluating apoptosis, autophagy and proteasome inhibition, with the anticancer properties being mainly attributed to the <i>Hib-ester</i> and <i>Hib-carbaldehyde</i>, while the proteasome inhibition of the extract could also be ascribed to the presence of anthocyanins, a class of secondary metabolites already known for their proteasome inhibitory activity.
format article
author Alessio Malacrida
Valeria Cavalloro
Emanuela Martino
Giosuè Costa
Francesca Alessandra Ambrosio
Stefano Alcaro
Roberta Rigolio
Arianna Cassetti
Mariarosaria Miloso
Simona Collina
author_facet Alessio Malacrida
Valeria Cavalloro
Emanuela Martino
Giosuè Costa
Francesca Alessandra Ambrosio
Stefano Alcaro
Roberta Rigolio
Arianna Cassetti
Mariarosaria Miloso
Simona Collina
author_sort Alessio Malacrida
title Anti-Multiple Myeloma Potential of Secondary Metabolites from <i>Hibiscus sabdariffa</i>—Part 2
title_short Anti-Multiple Myeloma Potential of Secondary Metabolites from <i>Hibiscus sabdariffa</i>—Part 2
title_full Anti-Multiple Myeloma Potential of Secondary Metabolites from <i>Hibiscus sabdariffa</i>—Part 2
title_fullStr Anti-Multiple Myeloma Potential of Secondary Metabolites from <i>Hibiscus sabdariffa</i>—Part 2
title_full_unstemmed Anti-Multiple Myeloma Potential of Secondary Metabolites from <i>Hibiscus sabdariffa</i>—Part 2
title_sort anti-multiple myeloma potential of secondary metabolites from <i>hibiscus sabdariffa</i>—part 2
publisher MDPI AG
publishDate 2021
url https://doaj.org/article/e877108583c84a6291c723ade6122757
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