Anti-Multiple Myeloma Potential of Secondary Metabolites from <i>Hibiscus sabdariffa</i>—Part 2
Multiple Myeloma (MM) is an aggressive tumor causing millions of deaths every year and currently available therapies are often unsuccessful or correlated with severe side effects. In our previous work we demonstrated that the <i>Hibiscus sabdariffa</i> hydroalcoholic extract inhibits the...
Guardado en:
Autores principales: | , , , , , , , , , |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
MDPI AG
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/e877108583c84a6291c723ade6122757 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
id |
oai:doaj.org-article:e877108583c84a6291c723ade6122757 |
---|---|
record_format |
dspace |
spelling |
oai:doaj.org-article:e877108583c84a6291c723ade61227572021-11-11T18:34:22ZAnti-Multiple Myeloma Potential of Secondary Metabolites from <i>Hibiscus sabdariffa</i>—Part 210.3390/molecules262165961420-3049https://doaj.org/article/e877108583c84a6291c723ade61227572021-10-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/21/6596https://doaj.org/toc/1420-3049Multiple Myeloma (MM) is an aggressive tumor causing millions of deaths every year and currently available therapies are often unsuccessful or correlated with severe side effects. In our previous work we demonstrated that the <i>Hibiscus sabdariffa</i> hydroalcoholic extract inhibits the growth of the MM cell line and we isolated two metabolites responsible for the activity: <i>Hib-ester</i> and <i>Hib-carbaldehyde</i>. Herein we report their interaction with proteasome, one of the main targets in the fight against MM. The molecular modelling study outlined a good interaction of both compounds with the target and these results prompted us to investigate their potential to inhibit proteasome. Metabolites were then isolated from the calyces and an extract with a high content of <i>Hib-ester</i> and <i>Hib-carbaldehyde</i> was prepared. An anticancer profile was drawn, evaluating apoptosis, autophagy and proteasome inhibition, with the anticancer properties being mainly attributed to the <i>Hib-ester</i> and <i>Hib-carbaldehyde</i>, while the proteasome inhibition of the extract could also be ascribed to the presence of anthocyanins, a class of secondary metabolites already known for their proteasome inhibitory activity.Alessio MalacridaValeria CavalloroEmanuela MartinoGiosuè CostaFrancesca Alessandra AmbrosioStefano AlcaroRoberta RigolioArianna CassettiMariarosaria MilosoSimona CollinaMDPI AGarticle<i>Hibiscus sabdariffa</i><i>Hib-ester</i><i>Hib-carbaldehyde</i>anthocyaninsproteasomemultiple myelomaOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6596, p 6596 (2021) |
institution |
DOAJ |
collection |
DOAJ |
language |
EN |
topic |
<i>Hibiscus sabdariffa</i> <i>Hib-ester</i> <i>Hib-carbaldehyde</i> anthocyanins proteasome multiple myeloma Organic chemistry QD241-441 |
spellingShingle |
<i>Hibiscus sabdariffa</i> <i>Hib-ester</i> <i>Hib-carbaldehyde</i> anthocyanins proteasome multiple myeloma Organic chemistry QD241-441 Alessio Malacrida Valeria Cavalloro Emanuela Martino Giosuè Costa Francesca Alessandra Ambrosio Stefano Alcaro Roberta Rigolio Arianna Cassetti Mariarosaria Miloso Simona Collina Anti-Multiple Myeloma Potential of Secondary Metabolites from <i>Hibiscus sabdariffa</i>—Part 2 |
description |
Multiple Myeloma (MM) is an aggressive tumor causing millions of deaths every year and currently available therapies are often unsuccessful or correlated with severe side effects. In our previous work we demonstrated that the <i>Hibiscus sabdariffa</i> hydroalcoholic extract inhibits the growth of the MM cell line and we isolated two metabolites responsible for the activity: <i>Hib-ester</i> and <i>Hib-carbaldehyde</i>. Herein we report their interaction with proteasome, one of the main targets in the fight against MM. The molecular modelling study outlined a good interaction of both compounds with the target and these results prompted us to investigate their potential to inhibit proteasome. Metabolites were then isolated from the calyces and an extract with a high content of <i>Hib-ester</i> and <i>Hib-carbaldehyde</i> was prepared. An anticancer profile was drawn, evaluating apoptosis, autophagy and proteasome inhibition, with the anticancer properties being mainly attributed to the <i>Hib-ester</i> and <i>Hib-carbaldehyde</i>, while the proteasome inhibition of the extract could also be ascribed to the presence of anthocyanins, a class of secondary metabolites already known for their proteasome inhibitory activity. |
format |
article |
author |
Alessio Malacrida Valeria Cavalloro Emanuela Martino Giosuè Costa Francesca Alessandra Ambrosio Stefano Alcaro Roberta Rigolio Arianna Cassetti Mariarosaria Miloso Simona Collina |
author_facet |
Alessio Malacrida Valeria Cavalloro Emanuela Martino Giosuè Costa Francesca Alessandra Ambrosio Stefano Alcaro Roberta Rigolio Arianna Cassetti Mariarosaria Miloso Simona Collina |
author_sort |
Alessio Malacrida |
title |
Anti-Multiple Myeloma Potential of Secondary Metabolites from <i>Hibiscus sabdariffa</i>—Part 2 |
title_short |
Anti-Multiple Myeloma Potential of Secondary Metabolites from <i>Hibiscus sabdariffa</i>—Part 2 |
title_full |
Anti-Multiple Myeloma Potential of Secondary Metabolites from <i>Hibiscus sabdariffa</i>—Part 2 |
title_fullStr |
Anti-Multiple Myeloma Potential of Secondary Metabolites from <i>Hibiscus sabdariffa</i>—Part 2 |
title_full_unstemmed |
Anti-Multiple Myeloma Potential of Secondary Metabolites from <i>Hibiscus sabdariffa</i>—Part 2 |
title_sort |
anti-multiple myeloma potential of secondary metabolites from <i>hibiscus sabdariffa</i>—part 2 |
publisher |
MDPI AG |
publishDate |
2021 |
url |
https://doaj.org/article/e877108583c84a6291c723ade6122757 |
work_keys_str_mv |
AT alessiomalacrida antimultiplemyelomapotentialofsecondarymetabolitesfromihibiscussabdariffaipart2 AT valeriacavalloro antimultiplemyelomapotentialofsecondarymetabolitesfromihibiscussabdariffaipart2 AT emanuelamartino antimultiplemyelomapotentialofsecondarymetabolitesfromihibiscussabdariffaipart2 AT giosuecosta antimultiplemyelomapotentialofsecondarymetabolitesfromihibiscussabdariffaipart2 AT francescaalessandraambrosio antimultiplemyelomapotentialofsecondarymetabolitesfromihibiscussabdariffaipart2 AT stefanoalcaro antimultiplemyelomapotentialofsecondarymetabolitesfromihibiscussabdariffaipart2 AT robertarigolio antimultiplemyelomapotentialofsecondarymetabolitesfromihibiscussabdariffaipart2 AT ariannacassetti antimultiplemyelomapotentialofsecondarymetabolitesfromihibiscussabdariffaipart2 AT mariarosariamiloso antimultiplemyelomapotentialofsecondarymetabolitesfromihibiscussabdariffaipart2 AT simonacollina antimultiplemyelomapotentialofsecondarymetabolitesfromihibiscussabdariffaipart2 |
_version_ |
1718431795718914048 |