κB-Ras and Ral GTPases regulate acinar to ductal metaplasia during pancreatic adenocarcinoma development and pancreatitis

The molecular mechanisms of acinar-to-ductal metaplasia (ADM) in the course of pancreatitis and cancer development are unclear. Here, the authors show that loss of κB-Ras and consequent Ral activation promotes tumour initiation and progression through persistent ADM and enhanced cell proliferation

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Autores principales:	Stephanie Beel, Lina Kolloch, Lisa H. Apken, Lara Jürgens, Andrea Bolle, Nadine Sudhof, Sankar Ghosh, Eva Wardelmann, Michael Meisterernst, Konrad Steinestel, Andrea Oeckinghaus
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e878ae5e8abb4a2ba7984f050a3bbfcc
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spelling	oai:doaj.org-article:e878ae5e8abb4a2ba7984f050a3bbfcc2021-12-02T16:15:09ZκB-Ras and Ral GTPases regulate acinar to ductal metaplasia during pancreatic adenocarcinoma development and pancreatitis10.1038/s41467-020-17226-02041-1723https://doaj.org/article/e878ae5e8abb4a2ba7984f050a3bbfcc2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17226-0https://doaj.org/toc/2041-1723The molecular mechanisms of acinar-to-ductal metaplasia (ADM) in the course of pancreatitis and cancer development are unclear. Here, the authors show that loss of κB-Ras and consequent Ral activation promotes tumour initiation and progression through persistent ADM and enhanced cell proliferationStephanie BeelLina KollochLisa H. ApkenLara JürgensAndrea BolleNadine SudhofSankar GhoshEva WardelmannMichael MeisterernstKonrad SteinestelAndrea OeckinghausNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Stephanie Beel Lina Kolloch Lisa H. Apken Lara Jürgens Andrea Bolle Nadine Sudhof Sankar Ghosh Eva Wardelmann Michael Meisterernst Konrad Steinestel Andrea Oeckinghaus κB-Ras and Ral GTPases regulate acinar to ductal metaplasia during pancreatic adenocarcinoma development and pancreatitis
description	The molecular mechanisms of acinar-to-ductal metaplasia (ADM) in the course of pancreatitis and cancer development are unclear. Here, the authors show that loss of κB-Ras and consequent Ral activation promotes tumour initiation and progression through persistent ADM and enhanced cell proliferation
format	article
author	Stephanie Beel Lina Kolloch Lisa H. Apken Lara Jürgens Andrea Bolle Nadine Sudhof Sankar Ghosh Eva Wardelmann Michael Meisterernst Konrad Steinestel Andrea Oeckinghaus
author_facet	Stephanie Beel Lina Kolloch Lisa H. Apken Lara Jürgens Andrea Bolle Nadine Sudhof Sankar Ghosh Eva Wardelmann Michael Meisterernst Konrad Steinestel Andrea Oeckinghaus
author_sort	Stephanie Beel
title	κB-Ras and Ral GTPases regulate acinar to ductal metaplasia during pancreatic adenocarcinoma development and pancreatitis
title_short	κB-Ras and Ral GTPases regulate acinar to ductal metaplasia during pancreatic adenocarcinoma development and pancreatitis
title_full	κB-Ras and Ral GTPases regulate acinar to ductal metaplasia during pancreatic adenocarcinoma development and pancreatitis
title_fullStr	κB-Ras and Ral GTPases regulate acinar to ductal metaplasia during pancreatic adenocarcinoma development and pancreatitis
title_full_unstemmed	κB-Ras and Ral GTPases regulate acinar to ductal metaplasia during pancreatic adenocarcinoma development and pancreatitis
title_sort	κb-ras and ral gtpases regulate acinar to ductal metaplasia during pancreatic adenocarcinoma development and pancreatitis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e878ae5e8abb4a2ba7984f050a3bbfcc
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κB-Ras and Ral GTPases regulate acinar to ductal metaplasia during pancreatic adenocarcinoma development and pancreatitis

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