Over-expressing mitofusin-2 in healthy mature mammalian skeletal muscle does not alter mitochondrial bioenergetics.

Over-expressing mitofusin-2 in healthy mature mammalian skeletal muscle does not alter mitochondrial bioenergetics.

The role of mitofusin-2 (MFN-2) in regulating mitochondrial dynamics has been well-characterized in lower order eukaryotic cell lines through the complete ablation of MFN-2 protein. However, to support the contractile function of mature skeletal muscle, the subcellular architecture and constituent p...

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Autores principales: James S V Lally, Eric A F Herbst, Sarthak Matravadia, Amy C Maher, Christopher G R Perry, Renée Ventura-Clapier, Graham P Holloway
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
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Science
Q
Acceso en línea:https://doaj.org/article/e8798af2356844c3a6e8b6d9777e8fe3
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