VACCINE FORMULATION: ADSORPTION OF <I>Plasmodium falciparum</I> MSP-1 PEPTIDE 1585 ON ALUMINIUM HYDROXIDE

The Plasmodium falciparum merozoite surface protein 1 has been studied due to its potential to become a vaccine; likewise, the peptide 1585 which is located in the 42-kDa amino-terminal fragment induces protective immunity in primates. Despite the importance of antigen adsorption in the formulation...

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Autores principales:	Mary TRUJILLO, Luz M. SALAZAR, Jesús VALENCIA
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2011
Materias:	Adsorption aluminium hydroxide peptide vaccine <I>Plasmodium falciparum</I>. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/e87a4d85580040ddb4c31c8af83809eb
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spelling	oai:doaj.org-article:e87a4d85580040ddb4c31c8af83809eb2021-11-19T04:13:52ZVACCINE FORMULATION: ADSORPTION OF <I>Plasmodium falciparum</I> MSP-1 PEPTIDE 1585 ON ALUMINIUM HYDROXIDE0121-40042145-2660https://doaj.org/article/e87a4d85580040ddb4c31c8af83809eb2011-09-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/10070https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660The Plasmodium falciparum merozoite surface protein 1 has been studied due to its potential to become a vaccine; likewise, the peptide 1585 which is located in the 42-kDa amino-terminal fragment induces protective immunity in primates. Despite the importance of antigen adsorption in the formulation and production of vaccines containing aluminium adjuvant, the protein fragment adsorption on aluminium hydroxide has not been thoroughly studied. Electrostatic attraction, hydrophobic interaction and ligand exchange have been identified as the major mechanisms involved in antigen retention on the adsorbent surface. Peptide 1585 was synthesized, and its solubility, adsorption on aluminium hydroxide, as well as its molecule release have been studied here. Results allowed us to raise a model for the adsorption and release of this peptide, which are important parameters to establish optimal conditions for peptideadsorbent interaction and, therefore, their response as a vaccine. Results also established the reversibility of such process due to the phosphate ion effect. Thus, this work provides a starting point for research works, leading to further development of vaccine formulations containing highly purified synthetic antigens adsorbed on aluminium adjuvant.Mary TRUJILLOLuz M. SALAZARJesús VALENCIAUniversidad de AntioquiaarticleAdsorptionaluminium hydroxidepeptidevaccine<I>Plasmodium falciparum</I>.Food processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 18, Iss 2 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Adsorption aluminium hydroxide peptide vaccine <I>Plasmodium falciparum</I>. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	Adsorption aluminium hydroxide peptide vaccine <I>Plasmodium falciparum</I>. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Mary TRUJILLO Luz M. SALAZAR Jesús VALENCIA VACCINE FORMULATION: ADSORPTION OF <I>Plasmodium falciparum</I> MSP-1 PEPTIDE 1585 ON ALUMINIUM HYDROXIDE
description	The Plasmodium falciparum merozoite surface protein 1 has been studied due to its potential to become a vaccine; likewise, the peptide 1585 which is located in the 42-kDa amino-terminal fragment induces protective immunity in primates. Despite the importance of antigen adsorption in the formulation and production of vaccines containing aluminium adjuvant, the protein fragment adsorption on aluminium hydroxide has not been thoroughly studied. Electrostatic attraction, hydrophobic interaction and ligand exchange have been identified as the major mechanisms involved in antigen retention on the adsorbent surface. Peptide 1585 was synthesized, and its solubility, adsorption on aluminium hydroxide, as well as its molecule release have been studied here. Results allowed us to raise a model for the adsorption and release of this peptide, which are important parameters to establish optimal conditions for peptideadsorbent interaction and, therefore, their response as a vaccine. Results also established the reversibility of such process due to the phosphate ion effect. Thus, this work provides a starting point for research works, leading to further development of vaccine formulations containing highly purified synthetic antigens adsorbed on aluminium adjuvant.
format	article
author	Mary TRUJILLO Luz M. SALAZAR Jesús VALENCIA
author_facet	Mary TRUJILLO Luz M. SALAZAR Jesús VALENCIA
author_sort	Mary TRUJILLO
title	VACCINE FORMULATION: ADSORPTION OF <I>Plasmodium falciparum</I> MSP-1 PEPTIDE 1585 ON ALUMINIUM HYDROXIDE
title_short	VACCINE FORMULATION: ADSORPTION OF <I>Plasmodium falciparum</I> MSP-1 PEPTIDE 1585 ON ALUMINIUM HYDROXIDE
title_full	VACCINE FORMULATION: ADSORPTION OF <I>Plasmodium falciparum</I> MSP-1 PEPTIDE 1585 ON ALUMINIUM HYDROXIDE
title_fullStr	VACCINE FORMULATION: ADSORPTION OF <I>Plasmodium falciparum</I> MSP-1 PEPTIDE 1585 ON ALUMINIUM HYDROXIDE
title_full_unstemmed	VACCINE FORMULATION: ADSORPTION OF <I>Plasmodium falciparum</I> MSP-1 PEPTIDE 1585 ON ALUMINIUM HYDROXIDE
title_sort	vaccine formulation: adsorption of <i>plasmodium falciparum</i> msp-1 peptide 1585 on aluminium hydroxide
publisher	Universidad de Antioquia
publishDate	2011
url	https://doaj.org/article/e87a4d85580040ddb4c31c8af83809eb
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VACCINE FORMULATION: ADSORPTION OF <I>Plasmodium falciparum</I> MSP-1 PEPTIDE 1585 ON ALUMINIUM HYDROXIDE

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