Antifungal, optical, and mechanical properties of polymethylmethacrylate material incorporated with silanized zinc oxide nanoparticles

Krid Kamonkhantikul,1 Mansuang Arksornnukit,1 Hidekazu Takahashi2 1Department of Prosthodontics, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand; 2Oral Biomaterials Engineering, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan Back...

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Autores principales:	Kamonkhantikul K, Arksornnukit M, Takahashi H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Antifungal effect Optical properties Mechanical properties Silanized zinc oxide nanoparticles Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/e87c6830e1f048378130f2e501b9c444
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spelling	oai:doaj.org-article:e87c6830e1f048378130f2e501b9c4442021-12-02T00:39:20ZAntifungal, optical, and mechanical properties of polymethylmethacrylate material incorporated with silanized zinc oxide nanoparticles1178-2013https://doaj.org/article/e87c6830e1f048378130f2e501b9c4442017-03-01T00:00:00Zhttps://www.dovepress.com/antifungal-optical-and-mechanical-properties-of-polymethylmethacrylate-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Krid Kamonkhantikul,1 Mansuang Arksornnukit,1 Hidekazu Takahashi2 1Department of Prosthodontics, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand; 2Oral Biomaterials Engineering, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan Background: Fungal infected denture, which is typically composed of polymethylmethacrylate (PMMA), is a common problem for a denture wearer, especially an elderly patient with limited manual dexterity. Therefore, increasing the antifungal effect of denture by incorporating surface modification nanoparticles into the PMMA, while retaining its mechanical properties, is of interest. Aim of the study: This study aimed to evaluate antifungal, optical, and mechanical properties of heat-cured PMMA incorporated with different amounts of zinc oxide nanoparticles (ZnOnps) with or without methacryloxypropyltrimethoxysilane modification. Materials and methods: Specimens made from heat-cured PMMA containing 1.25, 2.5, and 5% (w/w) nonsilanized (Nosi) or silanized (Si) ZnOnps were evaluated. Specimens without filler served as control. The fungal assay was performed placing a Candida albicans suspension on the PMMA surface for 2 h, then Sabouraud Dextrose Broth was added, and growth after 24 h was determined by counting colony forming units on agar plates. A spectrophotometer was used to measure the color in L* (brightness), a* (red-green), b* (yellow-blue) and opacity of the experimental groups. Flexural strength and flexural modulus were determined using a three-point bending test on universal testing machine after 37°C water storage for 48 h and 1 month. Results: The antifungal, optical, and mechanical properties of the PMMA incorporated with ZnOnps changed depending on the amount. With the same amount of ZnOnps, the silanized groups demonstrated a greater reduction in C. albicans compared with the Nosi groups. The color difference (ΔE) and opacity of the Nosi groups were greater compared with the Si groups. The flexural strength of the Si groups, except for the 1.25% group, was significantly greater compared with the Nosi groups. Conclusion: PMMA incorporated with Si ZnOnps, particularly with 2.5% Si ZnOnps, had a greater antifungal effect, less color differences, and opacity compared with Nosi ZnOnps, while retaining its mechanical properties. Keywords: antifungal effect, optical properties, mechanical properties, silanized zinc oxide nanoparticlesKamonkhantikul KArksornnukit MTakahashi HDove Medical PressarticleAntifungal effectOptical propertiesMechanical propertiesSilanized zinc oxide nanoparticlesMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 2353-2360 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Antifungal effect Optical properties Mechanical properties Silanized zinc oxide nanoparticles Medicine (General) R5-920
spellingShingle	Antifungal effect Optical properties Mechanical properties Silanized zinc oxide nanoparticles Medicine (General) R5-920 Kamonkhantikul K Arksornnukit M Takahashi H Antifungal, optical, and mechanical properties of polymethylmethacrylate material incorporated with silanized zinc oxide nanoparticles
description	Krid Kamonkhantikul,1 Mansuang Arksornnukit,1 Hidekazu Takahashi2 1Department of Prosthodontics, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand; 2Oral Biomaterials Engineering, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan Background: Fungal infected denture, which is typically composed of polymethylmethacrylate (PMMA), is a common problem for a denture wearer, especially an elderly patient with limited manual dexterity. Therefore, increasing the antifungal effect of denture by incorporating surface modification nanoparticles into the PMMA, while retaining its mechanical properties, is of interest. Aim of the study: This study aimed to evaluate antifungal, optical, and mechanical properties of heat-cured PMMA incorporated with different amounts of zinc oxide nanoparticles (ZnOnps) with or without methacryloxypropyltrimethoxysilane modification. Materials and methods: Specimens made from heat-cured PMMA containing 1.25, 2.5, and 5% (w/w) nonsilanized (Nosi) or silanized (Si) ZnOnps were evaluated. Specimens without filler served as control. The fungal assay was performed placing a Candida albicans suspension on the PMMA surface for 2 h, then Sabouraud Dextrose Broth was added, and growth after 24 h was determined by counting colony forming units on agar plates. A spectrophotometer was used to measure the color in L* (brightness), a* (red-green), b* (yellow-blue) and opacity of the experimental groups. Flexural strength and flexural modulus were determined using a three-point bending test on universal testing machine after 37°C water storage for 48 h and 1 month. Results: The antifungal, optical, and mechanical properties of the PMMA incorporated with ZnOnps changed depending on the amount. With the same amount of ZnOnps, the silanized groups demonstrated a greater reduction in C. albicans compared with the Nosi groups. The color difference (ΔE) and opacity of the Nosi groups were greater compared with the Si groups. The flexural strength of the Si groups, except for the 1.25% group, was significantly greater compared with the Nosi groups. Conclusion: PMMA incorporated with Si ZnOnps, particularly with 2.5% Si ZnOnps, had a greater antifungal effect, less color differences, and opacity compared with Nosi ZnOnps, while retaining its mechanical properties. Keywords: antifungal effect, optical properties, mechanical properties, silanized zinc oxide nanoparticles
format	article
author	Kamonkhantikul K Arksornnukit M Takahashi H
author_facet	Kamonkhantikul K Arksornnukit M Takahashi H
author_sort	Kamonkhantikul K
title	Antifungal, optical, and mechanical properties of polymethylmethacrylate material incorporated with silanized zinc oxide nanoparticles
title_short	Antifungal, optical, and mechanical properties of polymethylmethacrylate material incorporated with silanized zinc oxide nanoparticles
title_full	Antifungal, optical, and mechanical properties of polymethylmethacrylate material incorporated with silanized zinc oxide nanoparticles
title_fullStr	Antifungal, optical, and mechanical properties of polymethylmethacrylate material incorporated with silanized zinc oxide nanoparticles
title_full_unstemmed	Antifungal, optical, and mechanical properties of polymethylmethacrylate material incorporated with silanized zinc oxide nanoparticles
title_sort	antifungal, optical, and mechanical properties of polymethylmethacrylate material incorporated with silanized zinc oxide nanoparticles
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/e87c6830e1f048378130f2e501b9c444
work_keys_str_mv	AT kamonkhantikulk antifungalopticalandmechanicalpropertiesofpolymethylmethacrylatematerialincorporatedwithsilanizedzincoxidenanoparticles AT arksornnukitm antifungalopticalandmechanicalpropertiesofpolymethylmethacrylatematerialincorporatedwithsilanizedzincoxidenanoparticles AT takahashih antifungalopticalandmechanicalpropertiesofpolymethylmethacrylatematerialincorporatedwithsilanizedzincoxidenanoparticles
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Antifungal, optical, and mechanical properties of polymethylmethacrylate material incorporated with silanized zinc oxide nanoparticles

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