Interferon-free combination therapies for the treatment of hepatitis C: current insights

Jacinta A Holmes, Alexander J Thompson Department of Gastroenterology, St Vincent's Hospital, University of Melbourne, Fitzroy, Victoria, Australia Abstract: The hepatitis C virus (HCV) treatment landscape has rapidly changed over the past 5 years. The development of direct-acting antiviral...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Holmes JA, Thompson AJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/e87e631571534da2b3fe5558f65d8546
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e87e631571534da2b3fe5558f65d8546
record_format	dspace
spelling	oai:doaj.org-article:e87e631571534da2b3fe5558f65d85462021-12-02T02:50:52ZInterferon-free combination therapies for the treatment of hepatitis C: current insights1179-1535https://doaj.org/article/e87e631571534da2b3fe5558f65d85462015-11-01T00:00:00Zhttps://www.dovepress.com/interferon-free-combination-therapies-for-the-treatment-of-hepatitis-c-peer-reviewed-article-HMERhttps://doaj.org/toc/1179-1535Jacinta A Holmes, Alexander J Thompson Department of Gastroenterology, St Vincent's Hospital, University of Melbourne, Fitzroy, Victoria, Australia Abstract: The hepatitis C virus (HCV) treatment landscape has rapidly changed over the past 5 years. The development of direct-acting antiviral (DAA) agents that specifically target various steps in the HCV lifecycle has revolutionized therapeutic options for patients with HCV, with the development of highly effective and well-tolerated oral interferon-free regimens. There are many DAAs that are currently in development or have recently been approved, which target different nonstructural HCV proteins and host targets that are essential for HCV replication. This review will focus on the different classes of DAAs and the various combinations that are in advanced development for the treatment of chronic HCV infection and will focus on the different regimens in specific patient populations. Keywords: interferon-free, direct-acting antivirals, HCV therapyHolmes JAThompson AJDove Medical PressarticleDiseases of the digestive system. GastroenterologyRC799-869ENHepatic Medicine: Evidence and Research, Vol 2015, Iss default, Pp 51-70 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	Diseases of the digestive system. Gastroenterology RC799-869 Holmes JA Thompson AJ Interferon-free combination therapies for the treatment of hepatitis C: current insights
description	Jacinta A Holmes, Alexander J Thompson Department of Gastroenterology, St Vincent's Hospital, University of Melbourne, Fitzroy, Victoria, Australia Abstract: The hepatitis C virus (HCV) treatment landscape has rapidly changed over the past 5 years. The development of direct-acting antiviral (DAA) agents that specifically target various steps in the HCV lifecycle has revolutionized therapeutic options for patients with HCV, with the development of highly effective and well-tolerated oral interferon-free regimens. There are many DAAs that are currently in development or have recently been approved, which target different nonstructural HCV proteins and host targets that are essential for HCV replication. This review will focus on the different classes of DAAs and the various combinations that are in advanced development for the treatment of chronic HCV infection and will focus on the different regimens in specific patient populations. Keywords: interferon-free, direct-acting antivirals, HCV therapy
format	article
author	Holmes JA Thompson AJ
author_facet	Holmes JA Thompson AJ
author_sort	Holmes JA
title	Interferon-free combination therapies for the treatment of hepatitis C: current insights
title_short	Interferon-free combination therapies for the treatment of hepatitis C: current insights
title_full	Interferon-free combination therapies for the treatment of hepatitis C: current insights
title_fullStr	Interferon-free combination therapies for the treatment of hepatitis C: current insights
title_full_unstemmed	Interferon-free combination therapies for the treatment of hepatitis C: current insights
title_sort	interferon-free combination therapies for the treatment of hepatitis c: current insights
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/e87e631571534da2b3fe5558f65d8546
work_keys_str_mv	AT holmesja interferonfreecombinationtherapiesforthetreatmentofhepatitisccurrentinsights AT thompsonaj interferonfreecombinationtherapiesforthetreatmentofhepatitisccurrentinsights
_version_	1718402133552791552

Interferon-free combination therapies for the treatment of hepatitis C: current insights

Ejemplares similares