Monocytes, Macrophages, and Their Potential Niches in Synovial Joints – Therapeutic Targets in Post-Traumatic Osteoarthritis?

Synovial joints are complex structures that enable normal locomotion. Following injury, they undergo a series of changes, including a prevalent inflammatory response. This increases the risk for development of osteoarthritis (OA), the most common joint disorder. In healthy joints, macrophages are th...

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Autores principales:	Patrick Haubruck, Marlene Magalhaes Pinto, Babak Moradi, Christopher B. Little, Rebecca Gentek
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	osteoarthritis monocyte - macrophage inflammation niche native immune functions synovitis Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/e88ce0f680fe45788f73d726244181a2
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spelling	oai:doaj.org-article:e88ce0f680fe45788f73d726244181a22021-11-04T07:25:56ZMonocytes, Macrophages, and Their Potential Niches in Synovial Joints – Therapeutic Targets in Post-Traumatic Osteoarthritis?1664-322410.3389/fimmu.2021.763702https://doaj.org/article/e88ce0f680fe45788f73d726244181a22021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.763702/fullhttps://doaj.org/toc/1664-3224Synovial joints are complex structures that enable normal locomotion. Following injury, they undergo a series of changes, including a prevalent inflammatory response. This increases the risk for development of osteoarthritis (OA), the most common joint disorder. In healthy joints, macrophages are the predominant immune cells. They regulate bone turnover, constantly scavenge debris from the joint cavity and, together with synovial fibroblasts, form a protective barrier. Macrophages thus work in concert with the non-hematopoietic stroma. In turn, the stroma provides a scaffold as well as molecular signals for macrophage survival and functional imprinting: “a macrophage niche”. These intricate cellular interactions are susceptible to perturbations like those induced by joint injury. With this review, we explore how the concepts of local tissue niches apply to synovial joints. We introduce the joint micro-anatomy and cellular players, and discuss their potential interactions in healthy joints, with an emphasis on molecular cues underlying their crosstalk and relevance to joint functionality. We then consider how these interactions are perturbed by joint injury and how they may contribute to OA pathogenesis. We conclude by discussing how understanding these changes might help identify novel therapeutic avenues with the potential of restoring joint function and reducing post-traumatic OA risk.Patrick HaubruckPatrick HaubruckMarlene Magalhaes PintoBabak MoradiChristopher B. LittleRebecca GentekFrontiers Media S.A.articleosteoarthritismonocyte - macrophageinflammationnichenative immune functionssynovitisImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	osteoarthritis monocyte - macrophage inflammation niche native immune functions synovitis Immunologic diseases. Allergy RC581-607
spellingShingle	osteoarthritis monocyte - macrophage inflammation niche native immune functions synovitis Immunologic diseases. Allergy RC581-607 Patrick Haubruck Patrick Haubruck Marlene Magalhaes Pinto Babak Moradi Christopher B. Little Rebecca Gentek Monocytes, Macrophages, and Their Potential Niches in Synovial Joints – Therapeutic Targets in Post-Traumatic Osteoarthritis?
description	Synovial joints are complex structures that enable normal locomotion. Following injury, they undergo a series of changes, including a prevalent inflammatory response. This increases the risk for development of osteoarthritis (OA), the most common joint disorder. In healthy joints, macrophages are the predominant immune cells. They regulate bone turnover, constantly scavenge debris from the joint cavity and, together with synovial fibroblasts, form a protective barrier. Macrophages thus work in concert with the non-hematopoietic stroma. In turn, the stroma provides a scaffold as well as molecular signals for macrophage survival and functional imprinting: “a macrophage niche”. These intricate cellular interactions are susceptible to perturbations like those induced by joint injury. With this review, we explore how the concepts of local tissue niches apply to synovial joints. We introduce the joint micro-anatomy and cellular players, and discuss their potential interactions in healthy joints, with an emphasis on molecular cues underlying their crosstalk and relevance to joint functionality. We then consider how these interactions are perturbed by joint injury and how they may contribute to OA pathogenesis. We conclude by discussing how understanding these changes might help identify novel therapeutic avenues with the potential of restoring joint function and reducing post-traumatic OA risk.
format	article
author	Patrick Haubruck Patrick Haubruck Marlene Magalhaes Pinto Babak Moradi Christopher B. Little Rebecca Gentek
author_facet	Patrick Haubruck Patrick Haubruck Marlene Magalhaes Pinto Babak Moradi Christopher B. Little Rebecca Gentek
author_sort	Patrick Haubruck
title	Monocytes, Macrophages, and Their Potential Niches in Synovial Joints – Therapeutic Targets in Post-Traumatic Osteoarthritis?
title_short	Monocytes, Macrophages, and Their Potential Niches in Synovial Joints – Therapeutic Targets in Post-Traumatic Osteoarthritis?
title_full	Monocytes, Macrophages, and Their Potential Niches in Synovial Joints – Therapeutic Targets in Post-Traumatic Osteoarthritis?
title_fullStr	Monocytes, Macrophages, and Their Potential Niches in Synovial Joints – Therapeutic Targets in Post-Traumatic Osteoarthritis?
title_full_unstemmed	Monocytes, Macrophages, and Their Potential Niches in Synovial Joints – Therapeutic Targets in Post-Traumatic Osteoarthritis?
title_sort	monocytes, macrophages, and their potential niches in synovial joints – therapeutic targets in post-traumatic osteoarthritis?
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/e88ce0f680fe45788f73d726244181a2
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Monocytes, Macrophages, and Their Potential Niches in Synovial Joints – Therapeutic Targets in Post-Traumatic Osteoarthritis?

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