Circular RNAs expression profiles in human gastric cancer

Abstract Circular RNAs (circRNAs) are implicated in a variety of cancers. However, the roles of circRNAs in gastric cancer (GC) remain largely unknown. In the current study, circRNAs expression profiles were screened in GC, using 5 pairs of GC and matched non-GC tissues with circRNA chip. Preliminar...

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Autores principales:	Yuan Dang, Xiaojuan Ouyang, Fan Zhang, Kai Wang, Youdong Lin, Baochang Sun, Yu Wang, Lie Wang, Qiaojia Huang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e88d1d520f674456b5acd2b1cd27ad16
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spelling	oai:doaj.org-article:e88d1d520f674456b5acd2b1cd27ad162021-12-02T15:06:09ZCircular RNAs expression profiles in human gastric cancer10.1038/s41598-017-09076-62045-2322https://doaj.org/article/e88d1d520f674456b5acd2b1cd27ad162017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09076-6https://doaj.org/toc/2045-2322Abstract Circular RNAs (circRNAs) are implicated in a variety of cancers. However, the roles of circRNAs in gastric cancer (GC) remain largely unknown. In the current study, circRNAs expression profiles were screened in GC, using 5 pairs of GC and matched non-GC tissues with circRNA chip. Preliminary results were verified with quantitative PCR (qRT-PCR). Briefly, total of 713 circRNAs were differentially expressed in GC tissues vs. non-GC tissues (fold change ≥ 2.0, p < 0.05): 191 were upregulated, whereas 522 were downregulated in GC tissues. qRT-PCR analysis of randomly selected 7 circRNAs from the 713 circRNAs in 50 paired of GC vs. non-GC control tissues confirmed the microarray data. Gene ontology (GO) and KEGG pathway analyses showed that many circRNAs are implicated in carcinogenesis. Among differentially expressed circRNAs, hsa_circ_0076304, hsa_circ_0035431, and hsa_circ_0076305 had the highest magnitude of change. These results provided a preliminary landscape of circRNAs expression profile in GC.Yuan DangXiaojuan OuyangFan ZhangKai WangYoudong LinBaochang SunYu WangLie WangQiaojia HuangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yuan Dang Xiaojuan Ouyang Fan Zhang Kai Wang Youdong Lin Baochang Sun Yu Wang Lie Wang Qiaojia Huang Circular RNAs expression profiles in human gastric cancer
description	Abstract Circular RNAs (circRNAs) are implicated in a variety of cancers. However, the roles of circRNAs in gastric cancer (GC) remain largely unknown. In the current study, circRNAs expression profiles were screened in GC, using 5 pairs of GC and matched non-GC tissues with circRNA chip. Preliminary results were verified with quantitative PCR (qRT-PCR). Briefly, total of 713 circRNAs were differentially expressed in GC tissues vs. non-GC tissues (fold change ≥ 2.0, p < 0.05): 191 were upregulated, whereas 522 were downregulated in GC tissues. qRT-PCR analysis of randomly selected 7 circRNAs from the 713 circRNAs in 50 paired of GC vs. non-GC control tissues confirmed the microarray data. Gene ontology (GO) and KEGG pathway analyses showed that many circRNAs are implicated in carcinogenesis. Among differentially expressed circRNAs, hsa_circ_0076304, hsa_circ_0035431, and hsa_circ_0076305 had the highest magnitude of change. These results provided a preliminary landscape of circRNAs expression profile in GC.
format	article
author	Yuan Dang Xiaojuan Ouyang Fan Zhang Kai Wang Youdong Lin Baochang Sun Yu Wang Lie Wang Qiaojia Huang
author_facet	Yuan Dang Xiaojuan Ouyang Fan Zhang Kai Wang Youdong Lin Baochang Sun Yu Wang Lie Wang Qiaojia Huang
author_sort	Yuan Dang
title	Circular RNAs expression profiles in human gastric cancer
title_short	Circular RNAs expression profiles in human gastric cancer
title_full	Circular RNAs expression profiles in human gastric cancer
title_fullStr	Circular RNAs expression profiles in human gastric cancer
title_full_unstemmed	Circular RNAs expression profiles in human gastric cancer
title_sort	circular rnas expression profiles in human gastric cancer
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e88d1d520f674456b5acd2b1cd27ad16
work_keys_str_mv	AT yuandang circularrnasexpressionprofilesinhumangastriccancer AT xiaojuanouyang circularrnasexpressionprofilesinhumangastriccancer AT fanzhang circularrnasexpressionprofilesinhumangastriccancer AT kaiwang circularrnasexpressionprofilesinhumangastriccancer AT youdonglin circularrnasexpressionprofilesinhumangastriccancer AT baochangsun circularrnasexpressionprofilesinhumangastriccancer AT yuwang circularrnasexpressionprofilesinhumangastriccancer AT liewang circularrnasexpressionprofilesinhumangastriccancer AT qiaojiahuang circularrnasexpressionprofilesinhumangastriccancer
_version_	1718388616284078080

Circular RNAs expression profiles in human gastric cancer

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