Long-Term renal function after implantation of continuous-flow left ventricular assist devices: A single center study

Background: Implantable continuous-flow left ventricular assist device (LVAD) improve renal function in advanced heart failure. However, the long-term effects of LVAD on renal function have not been investigated thoroughly. We aimed to assess long-term renal function in patients with LVAD support an...

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Autores principales:	Chie Bujo, Eisuke Amiya, Masaru Hatano, Junichi Ishida, Masaki Tsuji, Nobutaka Kakuda, Koichi Narita, Akihito Saito, Hiroki Yagi, Masahiko Ando, Shogo Shimada, Mitsutoshi Kimura, Osamu Kinoshita, Minoru Ono, Issei Komuro
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Left ventricular assist devices Renal function Right ventricular failure Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/e88f8a5e310e499eb7dcc76d0af3db05
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spelling	oai:doaj.org-article:e88f8a5e310e499eb7dcc76d0af3db052021-11-04T04:32:58ZLong-Term renal function after implantation of continuous-flow left ventricular assist devices: A single center study2352-906710.1016/j.ijcha.2021.100907https://doaj.org/article/e88f8a5e310e499eb7dcc76d0af3db052021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2352906721001950https://doaj.org/toc/2352-9067Background: Implantable continuous-flow left ventricular assist device (LVAD) improve renal function in advanced heart failure. However, the long-term effects of LVAD on renal function have not been investigated thoroughly. We aimed to assess long-term renal function in patients with LVAD support and to identify predictors for late deterioration in renal function (LDRF). Methods: One hundred patients underwent LVAD implantation as a bridge to transplant at the University of Tokyo Hospital between May 2011 and December 2018. We assessed renal function at intervals (preoperative, 1, 6, 12, 18, 24 and 30 months after LVAD implantation). We divided patients into two groups: “with LDRF,” whose renal function at 30 months had decreased by >25% compared with preoperatively (n = 14), and “without LDRF” (n = 55). Results: Renal function improved at 1 month, returned to preoperative levels at 6 months, and remained there up to 30 months after LVAD implantation. However, renal function impairment became evident in patients with LDRF 18 months after LVAD implantation. A ratio of right atrial pressure/pulmonary artery wedge pressure > 0.57 and left ventricular dimension diastole ≤ 67 mm were preoperative independent risk factors for LDRF. In addition, the incidence of perioperative acute kidney injury, ventricular arrhythmia, aortic insufficiency, and late right ventricular failure was significantly higher in patients with LDRF. Conclusion: LDRF after LVAD implantation corresponded to several risk factors, including a small left ventricle and LVAD-related complications, such as right ventricular failure.Chie BujoEisuke AmiyaMasaru HatanoJunichi IshidaMasaki TsujiNobutaka KakudaKoichi NaritaAkihito SaitoHiroki YagiMasahiko AndoShogo ShimadaMitsutoshi KimuraOsamu KinoshitaMinoru OnoIssei KomuroElsevierarticleLeft ventricular assist devicesRenal functionRight ventricular failureDiseases of the circulatory (Cardiovascular) systemRC666-701ENInternational Journal of Cardiology: Heart & Vasculature, Vol 37, Iss , Pp 100907- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Left ventricular assist devices Renal function Right ventricular failure Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Left ventricular assist devices Renal function Right ventricular failure Diseases of the circulatory (Cardiovascular) system RC666-701 Chie Bujo Eisuke Amiya Masaru Hatano Junichi Ishida Masaki Tsuji Nobutaka Kakuda Koichi Narita Akihito Saito Hiroki Yagi Masahiko Ando Shogo Shimada Mitsutoshi Kimura Osamu Kinoshita Minoru Ono Issei Komuro Long-Term renal function after implantation of continuous-flow left ventricular assist devices: A single center study
description	Background: Implantable continuous-flow left ventricular assist device (LVAD) improve renal function in advanced heart failure. However, the long-term effects of LVAD on renal function have not been investigated thoroughly. We aimed to assess long-term renal function in patients with LVAD support and to identify predictors for late deterioration in renal function (LDRF). Methods: One hundred patients underwent LVAD implantation as a bridge to transplant at the University of Tokyo Hospital between May 2011 and December 2018. We assessed renal function at intervals (preoperative, 1, 6, 12, 18, 24 and 30 months after LVAD implantation). We divided patients into two groups: “with LDRF,” whose renal function at 30 months had decreased by >25% compared with preoperatively (n = 14), and “without LDRF” (n = 55). Results: Renal function improved at 1 month, returned to preoperative levels at 6 months, and remained there up to 30 months after LVAD implantation. However, renal function impairment became evident in patients with LDRF 18 months after LVAD implantation. A ratio of right atrial pressure/pulmonary artery wedge pressure > 0.57 and left ventricular dimension diastole ≤ 67 mm were preoperative independent risk factors for LDRF. In addition, the incidence of perioperative acute kidney injury, ventricular arrhythmia, aortic insufficiency, and late right ventricular failure was significantly higher in patients with LDRF. Conclusion: LDRF after LVAD implantation corresponded to several risk factors, including a small left ventricle and LVAD-related complications, such as right ventricular failure.
format	article
author	Chie Bujo Eisuke Amiya Masaru Hatano Junichi Ishida Masaki Tsuji Nobutaka Kakuda Koichi Narita Akihito Saito Hiroki Yagi Masahiko Ando Shogo Shimada Mitsutoshi Kimura Osamu Kinoshita Minoru Ono Issei Komuro
author_facet	Chie Bujo Eisuke Amiya Masaru Hatano Junichi Ishida Masaki Tsuji Nobutaka Kakuda Koichi Narita Akihito Saito Hiroki Yagi Masahiko Ando Shogo Shimada Mitsutoshi Kimura Osamu Kinoshita Minoru Ono Issei Komuro
author_sort	Chie Bujo
title	Long-Term renal function after implantation of continuous-flow left ventricular assist devices: A single center study
title_short	Long-Term renal function after implantation of continuous-flow left ventricular assist devices: A single center study
title_full	Long-Term renal function after implantation of continuous-flow left ventricular assist devices: A single center study
title_fullStr	Long-Term renal function after implantation of continuous-flow left ventricular assist devices: A single center study
title_full_unstemmed	Long-Term renal function after implantation of continuous-flow left ventricular assist devices: A single center study
title_sort	long-term renal function after implantation of continuous-flow left ventricular assist devices: a single center study
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/e88f8a5e310e499eb7dcc76d0af3db05
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Long-Term renal function after implantation of continuous-flow left ventricular assist devices: A single center study

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