Nuclear PTEN safeguards pre-mRNA splicing to link Golgi apparatus for its tumor suppressive role

Nuclear PTEN safeguards pre-mRNA splicing to link Golgi apparatus for its tumor suppressive role

Cytoplasmic PTEN is a tumor suppressor that antagonises PI3K signalling. Here, the authors show that nuclear PTEN can interact with the spliceosomal proteins and drive pre-mRNA splicing in a phosphatase-independent manner, in particular, PTEN depletion promotes Golgi extension and secretion through...

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Autores principales: Shao-Ming Shen, Yan Ji, Cheng Zhang, Shuang-Shu Dong, Shuo Yang, Zhong Xiong, Meng-Kai Ge, Yun Yu, Li Xia, Meng Guo, Jin-Ke Cheng, Jun-Ling Liu, Jian-Xiu Yu, Guo-Qiang Chen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/e891dd98000d4ee2b6bd974847f91a47
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spelling oai:doaj.org-article:e891dd98000d4ee2b6bd974847f91a472021-12-02T14:41:16ZNuclear PTEN safeguards pre-mRNA splicing to link Golgi apparatus for its tumor suppressive role10.1038/s41467-018-04760-12041-1723https://doaj.org/article/e891dd98000d4ee2b6bd974847f91a472018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04760-1https://doaj.org/toc/2041-1723Cytoplasmic PTEN is a tumor suppressor that antagonises PI3K signalling. Here, the authors show that nuclear PTEN can interact with the spliceosomal proteins and drive pre-mRNA splicing in a phosphatase-independent manner, in particular, PTEN depletion promotes Golgi extension and secretion through GOLGA2 exon skipping.Shao-Ming ShenYan JiCheng ZhangShuang-Shu DongShuo YangZhong XiongMeng-Kai GeYun YuLi XiaMeng GuoJin-Ke ChengJun-Ling LiuJian-Xiu YuGuo-Qiang ChenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Shao-Ming Shen
Yan Ji
Cheng Zhang
Shuang-Shu Dong
Shuo Yang
Zhong Xiong
Meng-Kai Ge
Yun Yu
Li Xia
Meng Guo
Jin-Ke Cheng
Jun-Ling Liu
Jian-Xiu Yu
Guo-Qiang Chen
Nuclear PTEN safeguards pre-mRNA splicing to link Golgi apparatus for its tumor suppressive role
description Cytoplasmic PTEN is a tumor suppressor that antagonises PI3K signalling. Here, the authors show that nuclear PTEN can interact with the spliceosomal proteins and drive pre-mRNA splicing in a phosphatase-independent manner, in particular, PTEN depletion promotes Golgi extension and secretion through GOLGA2 exon skipping.
format article
author Shao-Ming Shen
Yan Ji
Cheng Zhang
Shuang-Shu Dong
Shuo Yang
Zhong Xiong
Meng-Kai Ge
Yun Yu
Li Xia
Meng Guo
Jin-Ke Cheng
Jun-Ling Liu
Jian-Xiu Yu
Guo-Qiang Chen
author_facet Shao-Ming Shen
Yan Ji
Cheng Zhang
Shuang-Shu Dong
Shuo Yang
Zhong Xiong
Meng-Kai Ge
Yun Yu
Li Xia
Meng Guo
Jin-Ke Cheng
Jun-Ling Liu
Jian-Xiu Yu
Guo-Qiang Chen
author_sort Shao-Ming Shen
title Nuclear PTEN safeguards pre-mRNA splicing to link Golgi apparatus for its tumor suppressive role
title_short Nuclear PTEN safeguards pre-mRNA splicing to link Golgi apparatus for its tumor suppressive role
title_full Nuclear PTEN safeguards pre-mRNA splicing to link Golgi apparatus for its tumor suppressive role
title_fullStr Nuclear PTEN safeguards pre-mRNA splicing to link Golgi apparatus for its tumor suppressive role
title_full_unstemmed Nuclear PTEN safeguards pre-mRNA splicing to link Golgi apparatus for its tumor suppressive role
title_sort nuclear pten safeguards pre-mrna splicing to link golgi apparatus for its tumor suppressive role
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/e891dd98000d4ee2b6bd974847f91a47
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