Expression and clinical significance of IL7R, NFATc2, and RNF213 in familial and sporadic multiple sclerosis

Abstract Multiple sclerosis (MS) is a chronic inflammatory and autoimmune disorder of the central nervous system characterized by myelin loss and axonal dysfunction. Increased production of inflammatory factors such as cytokines has been implicated in axon destruction. In the present study, we compa...

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Autores principales:	Seyedeh Zahra Hosseini Imani, Zohreh Hojati, Sheyda Khalilian, Fariba Dehghanian, Majid Kheirollahi, Mehdi Khorrami, Vahid Shaygannejad, Omid Mirmosayyeb
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e8949a6fbd884396b9d066621c42f8b5
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spelling	oai:doaj.org-article:e8949a6fbd884396b9d066621c42f8b52021-12-02T17:37:12ZExpression and clinical significance of IL7R, NFATc2, and RNF213 in familial and sporadic multiple sclerosis10.1038/s41598-021-98691-52045-2322https://doaj.org/article/e8949a6fbd884396b9d066621c42f8b52021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98691-5https://doaj.org/toc/2045-2322Abstract Multiple sclerosis (MS) is a chronic inflammatory and autoimmune disorder of the central nervous system characterized by myelin loss and axonal dysfunction. Increased production of inflammatory factors such as cytokines has been implicated in axon destruction. In the present study, we compared the expression level of IL7R, NFATc2, and RNF213 genes in the peripheral blood of 72 MS patients (37 familial MS, 35 sporadic MS) and 74 healthy controls (34 individuals with a family history of the disease, 40 healthy controls without a family history) via Real-time PCR. Our results showed that the expression level of IL7R was decreased in the sporadic patients in comparison with other groups. Additionally, there was an increased NFATc2 expression level in MS patients versus healthy controls. Increased expression of NFATc2 in sporadic and familial groups compared to the controls, and familial group versus FDR was also seen. Our results also represented an increased expression level of RNF213 in familial patients as compared to the control group. The similar RNF213 expression between sporadic and control group, as well as FDR and familial group was also seen. Diagnostic evaluation was performed by receiver operating characteristic (ROC) curve analysis and area under the curve (AUC) calculation. The correlation of clinical parameters including onset age and Expanded Disability Status Scale (EDSS) with our gene expression levels were also assessed. Overall, decreased expression level of IL7R in the sporadic cases and increased expression level of NFATc2 may be associated with the pathogenesis of MS disease. Confirmation of the effects of differential expression of RNF213 gene requires further studies in the wider statistical populations.Seyedeh Zahra Hosseini ImaniZohreh HojatiSheyda KhalilianFariba DehghanianMajid KheirollahiMehdi KhorramiVahid ShaygannejadOmid MirmosayyebNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Seyedeh Zahra Hosseini Imani Zohreh Hojati Sheyda Khalilian Fariba Dehghanian Majid Kheirollahi Mehdi Khorrami Vahid Shaygannejad Omid Mirmosayyeb Expression and clinical significance of IL7R, NFATc2, and RNF213 in familial and sporadic multiple sclerosis
description	Abstract Multiple sclerosis (MS) is a chronic inflammatory and autoimmune disorder of the central nervous system characterized by myelin loss and axonal dysfunction. Increased production of inflammatory factors such as cytokines has been implicated in axon destruction. In the present study, we compared the expression level of IL7R, NFATc2, and RNF213 genes in the peripheral blood of 72 MS patients (37 familial MS, 35 sporadic MS) and 74 healthy controls (34 individuals with a family history of the disease, 40 healthy controls without a family history) via Real-time PCR. Our results showed that the expression level of IL7R was decreased in the sporadic patients in comparison with other groups. Additionally, there was an increased NFATc2 expression level in MS patients versus healthy controls. Increased expression of NFATc2 in sporadic and familial groups compared to the controls, and familial group versus FDR was also seen. Our results also represented an increased expression level of RNF213 in familial patients as compared to the control group. The similar RNF213 expression between sporadic and control group, as well as FDR and familial group was also seen. Diagnostic evaluation was performed by receiver operating characteristic (ROC) curve analysis and area under the curve (AUC) calculation. The correlation of clinical parameters including onset age and Expanded Disability Status Scale (EDSS) with our gene expression levels were also assessed. Overall, decreased expression level of IL7R in the sporadic cases and increased expression level of NFATc2 may be associated with the pathogenesis of MS disease. Confirmation of the effects of differential expression of RNF213 gene requires further studies in the wider statistical populations.
format	article
author	Seyedeh Zahra Hosseini Imani Zohreh Hojati Sheyda Khalilian Fariba Dehghanian Majid Kheirollahi Mehdi Khorrami Vahid Shaygannejad Omid Mirmosayyeb
author_facet	Seyedeh Zahra Hosseini Imani Zohreh Hojati Sheyda Khalilian Fariba Dehghanian Majid Kheirollahi Mehdi Khorrami Vahid Shaygannejad Omid Mirmosayyeb
author_sort	Seyedeh Zahra Hosseini Imani
title	Expression and clinical significance of IL7R, NFATc2, and RNF213 in familial and sporadic multiple sclerosis
title_short	Expression and clinical significance of IL7R, NFATc2, and RNF213 in familial and sporadic multiple sclerosis
title_full	Expression and clinical significance of IL7R, NFATc2, and RNF213 in familial and sporadic multiple sclerosis
title_fullStr	Expression and clinical significance of IL7R, NFATc2, and RNF213 in familial and sporadic multiple sclerosis
title_full_unstemmed	Expression and clinical significance of IL7R, NFATc2, and RNF213 in familial and sporadic multiple sclerosis
title_sort	expression and clinical significance of il7r, nfatc2, and rnf213 in familial and sporadic multiple sclerosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e8949a6fbd884396b9d066621c42f8b5
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Expression and clinical significance of IL7R, NFATc2, and RNF213 in familial and sporadic multiple sclerosis

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