Differences in clinical severity of respiratory viral infections in hospitalized children

Abstract It is uncertain whether clinical severity of an infection varies by pathogen or by multiple infections. Using hospital-based surveillance in children, we investigate the range of clinical severity for patients singly, multiply, and not infected with a group of commonly circulating viruses i...

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Autores principales:	Benjamin M. Althouse, Stefan Flasche, Michiko Toizumi, Hien-Anh Thi Nguyen, Hien Minh Vo, Minh Nhat Le, Masahiro Hashizume, Koya Ariyoshi, Dang Duc Anh, Gail L. Rodgers, Keith P. Klugman, Hao Hu, Lay-Myint Yoshida
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e895ad5f25694278b515ba1b02abda95
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spelling	oai:doaj.org-article:e895ad5f25694278b515ba1b02abda952021-12-02T13:19:21ZDifferences in clinical severity of respiratory viral infections in hospitalized children10.1038/s41598-021-84423-22045-2322https://doaj.org/article/e895ad5f25694278b515ba1b02abda952021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84423-2https://doaj.org/toc/2045-2322Abstract It is uncertain whether clinical severity of an infection varies by pathogen or by multiple infections. Using hospital-based surveillance in children, we investigate the range of clinical severity for patients singly, multiply, and not infected with a group of commonly circulating viruses in Nha Trang, Vietnam. RT-PCR was performed to detect 13 respiratory viruses in nasopharyngeal samples from enrolled patients. We apply a novel clinical severity score and examine associations with the odds of being severe and differences in raw severity scores. We find no difference in severity between 0-, 1-, and 2-concurrent infections and little differences in severity between specific viruses. We find RSV and HMPV infections to be associated with 2- and 1.5-fold increase in odds of being severe, respectively, and that infection with ADV is consistently associated with lower risk of severity. Clinically, based on the results here, if RSV or HMPV virus is suspected, PCR testing for confirmatory diagnosis and for detection of multiple coinfecting viruses would be fruitful to assess whether a patient’s disease course is going to be severe.Benjamin M. AlthouseStefan FlascheMichiko ToizumiHien-Anh Thi NguyenHien Minh VoMinh Nhat LeMasahiro HashizumeKoya AriyoshiDang Duc AnhGail L. RodgersKeith P. KlugmanHao HuLay-Myint YoshidaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Benjamin M. Althouse Stefan Flasche Michiko Toizumi Hien-Anh Thi Nguyen Hien Minh Vo Minh Nhat Le Masahiro Hashizume Koya Ariyoshi Dang Duc Anh Gail L. Rodgers Keith P. Klugman Hao Hu Lay-Myint Yoshida Differences in clinical severity of respiratory viral infections in hospitalized children
description	Abstract It is uncertain whether clinical severity of an infection varies by pathogen or by multiple infections. Using hospital-based surveillance in children, we investigate the range of clinical severity for patients singly, multiply, and not infected with a group of commonly circulating viruses in Nha Trang, Vietnam. RT-PCR was performed to detect 13 respiratory viruses in nasopharyngeal samples from enrolled patients. We apply a novel clinical severity score and examine associations with the odds of being severe and differences in raw severity scores. We find no difference in severity between 0-, 1-, and 2-concurrent infections and little differences in severity between specific viruses. We find RSV and HMPV infections to be associated with 2- and 1.5-fold increase in odds of being severe, respectively, and that infection with ADV is consistently associated with lower risk of severity. Clinically, based on the results here, if RSV or HMPV virus is suspected, PCR testing for confirmatory diagnosis and for detection of multiple coinfecting viruses would be fruitful to assess whether a patient’s disease course is going to be severe.
format	article
author	Benjamin M. Althouse Stefan Flasche Michiko Toizumi Hien-Anh Thi Nguyen Hien Minh Vo Minh Nhat Le Masahiro Hashizume Koya Ariyoshi Dang Duc Anh Gail L. Rodgers Keith P. Klugman Hao Hu Lay-Myint Yoshida
author_facet	Benjamin M. Althouse Stefan Flasche Michiko Toizumi Hien-Anh Thi Nguyen Hien Minh Vo Minh Nhat Le Masahiro Hashizume Koya Ariyoshi Dang Duc Anh Gail L. Rodgers Keith P. Klugman Hao Hu Lay-Myint Yoshida
author_sort	Benjamin M. Althouse
title	Differences in clinical severity of respiratory viral infections in hospitalized children
title_short	Differences in clinical severity of respiratory viral infections in hospitalized children
title_full	Differences in clinical severity of respiratory viral infections in hospitalized children
title_fullStr	Differences in clinical severity of respiratory viral infections in hospitalized children
title_full_unstemmed	Differences in clinical severity of respiratory viral infections in hospitalized children
title_sort	differences in clinical severity of respiratory viral infections in hospitalized children
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e895ad5f25694278b515ba1b02abda95
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Differences in clinical severity of respiratory viral infections in hospitalized children

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