Resistance to targeted therapies as a multifactorial, gradual adaptation to inhibitor specific selective pressures

Acquired resistance to cancer therapies reflects the ability of cancers to adapt to therapy-imposed selective pressures. Here, the authors elucidate the dynamics of developing resistance to ALK inhibitors in an ALK+ lung cancer cell line showing that resistance originates from drug-specific tolerant...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Robert Vander Velde, Nara Yoon, Viktoriya Marusyk, Arda Durmaz, Andrew Dhawan, Daria Miroshnychenko, Diego Lozano-Peral, Bina Desai, Olena Balynska, Jan Poleszhuk, Liu Kenian, Mingxiang Teng, Mohamed Abazeed, Omar Mian, Aik Choon Tan, Eric Haura, Jacob Scott, Andriy Marusyk
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e895fc30a0004dd4847eaf04af82db31
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e895fc30a0004dd4847eaf04af82db31
record_format	dspace
spelling	oai:doaj.org-article:e895fc30a0004dd4847eaf04af82db312021-12-02T17:16:09ZResistance to targeted therapies as a multifactorial, gradual adaptation to inhibitor specific selective pressures10.1038/s41467-020-16212-w2041-1723https://doaj.org/article/e895fc30a0004dd4847eaf04af82db312020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16212-whttps://doaj.org/toc/2041-1723Acquired resistance to cancer therapies reflects the ability of cancers to adapt to therapy-imposed selective pressures. Here, the authors elucidate the dynamics of developing resistance to ALK inhibitors in an ALK+ lung cancer cell line showing that resistance originates from drug-specific tolerant cancer cells and it develops as a gradual adaptation.Robert Vander VeldeNara YoonViktoriya MarusykArda DurmazAndrew DhawanDaria MiroshnychenkoDiego Lozano-PeralBina DesaiOlena BalynskaJan PoleszhukLiu KenianMingxiang TengMohamed AbazeedOmar MianAik Choon TanEric HauraJacob ScottAndriy MarusykNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Robert Vander Velde Nara Yoon Viktoriya Marusyk Arda Durmaz Andrew Dhawan Daria Miroshnychenko Diego Lozano-Peral Bina Desai Olena Balynska Jan Poleszhuk Liu Kenian Mingxiang Teng Mohamed Abazeed Omar Mian Aik Choon Tan Eric Haura Jacob Scott Andriy Marusyk Resistance to targeted therapies as a multifactorial, gradual adaptation to inhibitor specific selective pressures
description	Acquired resistance to cancer therapies reflects the ability of cancers to adapt to therapy-imposed selective pressures. Here, the authors elucidate the dynamics of developing resistance to ALK inhibitors in an ALK+ lung cancer cell line showing that resistance originates from drug-specific tolerant cancer cells and it develops as a gradual adaptation.
format	article
author	Robert Vander Velde Nara Yoon Viktoriya Marusyk Arda Durmaz Andrew Dhawan Daria Miroshnychenko Diego Lozano-Peral Bina Desai Olena Balynska Jan Poleszhuk Liu Kenian Mingxiang Teng Mohamed Abazeed Omar Mian Aik Choon Tan Eric Haura Jacob Scott Andriy Marusyk
author_facet	Robert Vander Velde Nara Yoon Viktoriya Marusyk Arda Durmaz Andrew Dhawan Daria Miroshnychenko Diego Lozano-Peral Bina Desai Olena Balynska Jan Poleszhuk Liu Kenian Mingxiang Teng Mohamed Abazeed Omar Mian Aik Choon Tan Eric Haura Jacob Scott Andriy Marusyk
author_sort	Robert Vander Velde
title	Resistance to targeted therapies as a multifactorial, gradual adaptation to inhibitor specific selective pressures
title_short	Resistance to targeted therapies as a multifactorial, gradual adaptation to inhibitor specific selective pressures
title_full	Resistance to targeted therapies as a multifactorial, gradual adaptation to inhibitor specific selective pressures
title_fullStr	Resistance to targeted therapies as a multifactorial, gradual adaptation to inhibitor specific selective pressures
title_full_unstemmed	Resistance to targeted therapies as a multifactorial, gradual adaptation to inhibitor specific selective pressures
title_sort	resistance to targeted therapies as a multifactorial, gradual adaptation to inhibitor specific selective pressures
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e895fc30a0004dd4847eaf04af82db31
work_keys_str_mv	AT robertvandervelde resistancetotargetedtherapiesasamultifactorialgradualadaptationtoinhibitorspecificselectivepressures AT narayoon resistancetotargetedtherapiesasamultifactorialgradualadaptationtoinhibitorspecificselectivepressures AT viktoriyamarusyk resistancetotargetedtherapiesasamultifactorialgradualadaptationtoinhibitorspecificselectivepressures AT ardadurmaz resistancetotargetedtherapiesasamultifactorialgradualadaptationtoinhibitorspecificselectivepressures AT andrewdhawan resistancetotargetedtherapiesasamultifactorialgradualadaptationtoinhibitorspecificselectivepressures AT dariamiroshnychenko resistancetotargetedtherapiesasamultifactorialgradualadaptationtoinhibitorspecificselectivepressures AT diegolozanoperal resistancetotargetedtherapiesasamultifactorialgradualadaptationtoinhibitorspecificselectivepressures AT binadesai resistancetotargetedtherapiesasamultifactorialgradualadaptationtoinhibitorspecificselectivepressures AT olenabalynska resistancetotargetedtherapiesasamultifactorialgradualadaptationtoinhibitorspecificselectivepressures AT janpoleszhuk resistancetotargetedtherapiesasamultifactorialgradualadaptationtoinhibitorspecificselectivepressures AT liukenian resistancetotargetedtherapiesasamultifactorialgradualadaptationtoinhibitorspecificselectivepressures AT mingxiangteng resistancetotargetedtherapiesasamultifactorialgradualadaptationtoinhibitorspecificselectivepressures AT mohamedabazeed resistancetotargetedtherapiesasamultifactorialgradualadaptationtoinhibitorspecificselectivepressures AT omarmian resistancetotargetedtherapiesasamultifactorialgradualadaptationtoinhibitorspecificselectivepressures AT aikchoontan resistancetotargetedtherapiesasamultifactorialgradualadaptationtoinhibitorspecificselectivepressures AT erichaura resistancetotargetedtherapiesasamultifactorialgradualadaptationtoinhibitorspecificselectivepressures AT jacobscott resistancetotargetedtherapiesasamultifactorialgradualadaptationtoinhibitorspecificselectivepressures AT andriymarusyk resistancetotargetedtherapiesasamultifactorialgradualadaptationtoinhibitorspecificselectivepressures
_version_	1718381234536579072

Resistance to targeted therapies as a multifactorial, gradual adaptation to inhibitor specific selective pressures

Ejemplares similares