Biosynthesis of thiocarboxylic acid-containing natural products

Thioplatensimycin (thioPTM) and thioplatencin (thioPTN) are recently discovered thiocarboxylic acid congeners of the antibacterial compounds PTM and PTN. Here, the authors identify a thioacid cassette encoding PtmA3 and PtmU4 that are responsible for carboxylate activation and sulfur transfer, respe...

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Autores principales:	Liao-Bin Dong, Jeffrey D. Rudolf, Dingding Kang, Nan Wang, Cyndi Qixin He, Youchao Deng, Yong Huang, K. N. Houk, Yanwen Duan, Ben Shen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e89626e016aa4682b96d98ed37e5b624
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spelling	oai:doaj.org-article:e89626e016aa4682b96d98ed37e5b6242021-12-02T16:49:16ZBiosynthesis of thiocarboxylic acid-containing natural products10.1038/s41467-018-04747-y2041-1723https://doaj.org/article/e89626e016aa4682b96d98ed37e5b6242018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04747-yhttps://doaj.org/toc/2041-1723Thioplatensimycin (thioPTM) and thioplatencin (thioPTN) are recently discovered thiocarboxylic acid congeners of the antibacterial compounds PTM and PTN. Here, the authors identify a thioacid cassette encoding PtmA3 and PtmU4 that are responsible for carboxylate activation and sulfur transfer, respectively.Liao-Bin DongJeffrey D. RudolfDingding KangNan WangCyndi Qixin HeYouchao DengYong HuangK. N. HoukYanwen DuanBen ShenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Liao-Bin Dong Jeffrey D. Rudolf Dingding Kang Nan Wang Cyndi Qixin He Youchao Deng Yong Huang K. N. Houk Yanwen Duan Ben Shen Biosynthesis of thiocarboxylic acid-containing natural products
description	Thioplatensimycin (thioPTM) and thioplatencin (thioPTN) are recently discovered thiocarboxylic acid congeners of the antibacterial compounds PTM and PTN. Here, the authors identify a thioacid cassette encoding PtmA3 and PtmU4 that are responsible for carboxylate activation and sulfur transfer, respectively.
format	article
author	Liao-Bin Dong Jeffrey D. Rudolf Dingding Kang Nan Wang Cyndi Qixin He Youchao Deng Yong Huang K. N. Houk Yanwen Duan Ben Shen
author_facet	Liao-Bin Dong Jeffrey D. Rudolf Dingding Kang Nan Wang Cyndi Qixin He Youchao Deng Yong Huang K. N. Houk Yanwen Duan Ben Shen
author_sort	Liao-Bin Dong
title	Biosynthesis of thiocarboxylic acid-containing natural products
title_short	Biosynthesis of thiocarboxylic acid-containing natural products
title_full	Biosynthesis of thiocarboxylic acid-containing natural products
title_fullStr	Biosynthesis of thiocarboxylic acid-containing natural products
title_full_unstemmed	Biosynthesis of thiocarboxylic acid-containing natural products
title_sort	biosynthesis of thiocarboxylic acid-containing natural products
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e89626e016aa4682b96d98ed37e5b624
work_keys_str_mv	AT liaobindong biosynthesisofthiocarboxylicacidcontainingnaturalproducts AT jeffreydrudolf biosynthesisofthiocarboxylicacidcontainingnaturalproducts AT dingdingkang biosynthesisofthiocarboxylicacidcontainingnaturalproducts AT nanwang biosynthesisofthiocarboxylicacidcontainingnaturalproducts AT cyndiqixinhe biosynthesisofthiocarboxylicacidcontainingnaturalproducts AT youchaodeng biosynthesisofthiocarboxylicacidcontainingnaturalproducts AT yonghuang biosynthesisofthiocarboxylicacidcontainingnaturalproducts AT knhouk biosynthesisofthiocarboxylicacidcontainingnaturalproducts AT yanwenduan biosynthesisofthiocarboxylicacidcontainingnaturalproducts AT benshen biosynthesisofthiocarboxylicacidcontainingnaturalproducts
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Biosynthesis of thiocarboxylic acid-containing natural products

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