Mussel-inspired adhesive antioxidant antibacterial hemostatic composite hydrogel wound dressing via photo-polymerization for infected skin wound healing

With the increasing prevalence of drug-resistant bacterial infections and the slow healing of chronically infected wounds, the development of new antibacterial and accelerated wound healing dressings has become a serious challenge. In order to solve this problem, we developed photo-crosslinked multi...

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Autores principales:	Yutong Yang, Yongping Liang, Jueying Chen, Xianglong Duan, Baolin Guo
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2022
Materias:	Chitosan Wound dressing Antibacterial Wound healing Hemostat Infected skin wound Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/e896f5422d294965a04f8e1e574dc129
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spelling	oai:doaj.org-article:e896f5422d294965a04f8e1e574dc1292021-11-04T04:35:20ZMussel-inspired adhesive antioxidant antibacterial hemostatic composite hydrogel wound dressing via photo-polymerization for infected skin wound healing2452-199X10.1016/j.bioactmat.2021.06.014https://doaj.org/article/e896f5422d294965a04f8e1e574dc1292022-02-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2452199X21003005https://doaj.org/toc/2452-199XWith the increasing prevalence of drug-resistant bacterial infections and the slow healing of chronically infected wounds, the development of new antibacterial and accelerated wound healing dressings has become a serious challenge. In order to solve this problem, we developed photo-crosslinked multifunctional antibacterial adhesive anti-oxidant hemostatic hydrogel dressings based on polyethylene glycol monomethyl ether modified glycidyl methacrylate functionalized chitosan (CSG-PEG), methacrylamide dopamine (DMA) and zinc ion for disinfection of drug-resistant bacteria and promoting wound healing. The mechanical properties, rheological properties and morphology of hydrogels were characterized, and the biocompatibility of these hydrogels was studied through cell compatibility and blood compatibility tests. These hydrogels were tested for the in vitro blood-clotting ability of whole blood and showed good hemostatic ability in the mouse liver hemorrhage model and the mouse-tail amputation model. In addition, it has been confirmed that the multifunctional hydrogels have good inherent antibacterial properties against Methicillin-resistant Staphylococcus aureus (MRSA). In the full-thickness skin defect model infected with MRSA, the wound closure ratio, thickness of granulation tissue, number of collagen deposition, regeneration of blood vessels and hair follicles were measured. The inflammation-related cytokines (CD68) and angiogenesis-related cytokines (CD31) expressed during skin regeneration were studied. All results indicate that these multifunctional antibacterial adhesive hemostatic hydrogels have better healing effects than commercially available Tegaderm™ Film, revealing that they have become promising alternative in the healing of infected wounds.Yutong YangYongping LiangJueying ChenXianglong DuanBaolin GuoKeAi Communications Co., Ltd.articleChitosanWound dressingAntibacterialWound healingHemostatInfected skin woundMaterials of engineering and construction. Mechanics of materialsTA401-492Biology (General)QH301-705.5ENBioactive Materials, Vol 8, Iss , Pp 341-354 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chitosan Wound dressing Antibacterial Wound healing Hemostat Infected skin wound Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
spellingShingle	Chitosan Wound dressing Antibacterial Wound healing Hemostat Infected skin wound Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5 Yutong Yang Yongping Liang Jueying Chen Xianglong Duan Baolin Guo Mussel-inspired adhesive antioxidant antibacterial hemostatic composite hydrogel wound dressing via photo-polymerization for infected skin wound healing
description	With the increasing prevalence of drug-resistant bacterial infections and the slow healing of chronically infected wounds, the development of new antibacterial and accelerated wound healing dressings has become a serious challenge. In order to solve this problem, we developed photo-crosslinked multifunctional antibacterial adhesive anti-oxidant hemostatic hydrogel dressings based on polyethylene glycol monomethyl ether modified glycidyl methacrylate functionalized chitosan (CSG-PEG), methacrylamide dopamine (DMA) and zinc ion for disinfection of drug-resistant bacteria and promoting wound healing. The mechanical properties, rheological properties and morphology of hydrogels were characterized, and the biocompatibility of these hydrogels was studied through cell compatibility and blood compatibility tests. These hydrogels were tested for the in vitro blood-clotting ability of whole blood and showed good hemostatic ability in the mouse liver hemorrhage model and the mouse-tail amputation model. In addition, it has been confirmed that the multifunctional hydrogels have good inherent antibacterial properties against Methicillin-resistant Staphylococcus aureus (MRSA). In the full-thickness skin defect model infected with MRSA, the wound closure ratio, thickness of granulation tissue, number of collagen deposition, regeneration of blood vessels and hair follicles were measured. The inflammation-related cytokines (CD68) and angiogenesis-related cytokines (CD31) expressed during skin regeneration were studied. All results indicate that these multifunctional antibacterial adhesive hemostatic hydrogels have better healing effects than commercially available Tegaderm™ Film, revealing that they have become promising alternative in the healing of infected wounds.
format	article
author	Yutong Yang Yongping Liang Jueying Chen Xianglong Duan Baolin Guo
author_facet	Yutong Yang Yongping Liang Jueying Chen Xianglong Duan Baolin Guo
author_sort	Yutong Yang
title	Mussel-inspired adhesive antioxidant antibacterial hemostatic composite hydrogel wound dressing via photo-polymerization for infected skin wound healing
title_short	Mussel-inspired adhesive antioxidant antibacterial hemostatic composite hydrogel wound dressing via photo-polymerization for infected skin wound healing
title_full	Mussel-inspired adhesive antioxidant antibacterial hemostatic composite hydrogel wound dressing via photo-polymerization for infected skin wound healing
title_fullStr	Mussel-inspired adhesive antioxidant antibacterial hemostatic composite hydrogel wound dressing via photo-polymerization for infected skin wound healing
title_full_unstemmed	Mussel-inspired adhesive antioxidant antibacterial hemostatic composite hydrogel wound dressing via photo-polymerization for infected skin wound healing
title_sort	mussel-inspired adhesive antioxidant antibacterial hemostatic composite hydrogel wound dressing via photo-polymerization for infected skin wound healing
publisher	KeAi Communications Co., Ltd.
publishDate	2022
url	https://doaj.org/article/e896f5422d294965a04f8e1e574dc129
work_keys_str_mv	AT yutongyang musselinspiredadhesiveantioxidantantibacterialhemostaticcompositehydrogelwounddressingviaphotopolymerizationforinfectedskinwoundhealing AT yongpingliang musselinspiredadhesiveantioxidantantibacterialhemostaticcompositehydrogelwounddressingviaphotopolymerizationforinfectedskinwoundhealing AT jueyingchen musselinspiredadhesiveantioxidantantibacterialhemostaticcompositehydrogelwounddressingviaphotopolymerizationforinfectedskinwoundhealing AT xianglongduan musselinspiredadhesiveantioxidantantibacterialhemostaticcompositehydrogelwounddressingviaphotopolymerizationforinfectedskinwoundhealing AT baolinguo musselinspiredadhesiveantioxidantantibacterialhemostaticcompositehydrogelwounddressingviaphotopolymerizationforinfectedskinwoundhealing
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Mussel-inspired adhesive antioxidant antibacterial hemostatic composite hydrogel wound dressing via photo-polymerization for infected skin wound healing

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