Survival changes in patients with small cell lung cancer and disparities between different sexes, socioeconomic statuses and ages

Abstract Small cell lung cancer (SCLC), as a proportion, makes up only 15–17% of lung cancer cases. The development of treatments for SCLC has remained stagnant for decades, and SCLC is expected to persist as a threat to human health. To date, no publications based on large populations have been rep...

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Autores principales:	Shuncong Wang, Jianjun Tang, Tiantian Sun, Xiaobin Zheng, Jie Li, Hongliu Sun, Xiuling Zhou, Cuiling Zhou, Hongyu Zhang, Zhibin Cheng, Haiqing Ma, Huanhuan Sun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e89779411d734d8199d2f1a54c1172c6
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spelling	oai:doaj.org-article:e89779411d734d8199d2f1a54c1172c62021-12-02T12:30:46ZSurvival changes in patients with small cell lung cancer and disparities between different sexes, socioeconomic statuses and ages10.1038/s41598-017-01571-02045-2322https://doaj.org/article/e89779411d734d8199d2f1a54c1172c62017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01571-0https://doaj.org/toc/2045-2322Abstract Small cell lung cancer (SCLC), as a proportion, makes up only 15–17% of lung cancer cases. The development of treatments for SCLC has remained stagnant for decades, and SCLC is expected to persist as a threat to human health. To date, no publications based on large populations have been reported. We calculated survival changes in patients with SCLC during each decade between 1983 and 2012 to determine the roles of race, sex, age, and socioeconomic status (SES) on survival rates based on the Surveillance, Epidemiology, and End Results (SEER) registries. In total, 106,296 patients with SCLC were identified, with the overall incidence per 100,000 decreasing each decade from 9.6 to 7.8 to 5.8. The median survival for SCLC remained 7 months, and the 12-month relative survival rates (RSRs) remained relatively stable at 32.9%, 33.2% and 33.2% during each decade. The 5-year RSRs significantly improved from 4.9% to 5.9% to 6.4% during each decade, but remained extremely low. In addition, a narrowing of the survival gaps among SES groups and stable survival gaps between sexes were observed. Although the incidence of SCLC decreased during each decade, the overall survival remained relatively stable, highlighting the urgency of developing novel treatments and the importance of prevention and early detection.Shuncong WangJianjun TangTiantian SunXiaobin ZhengJie LiHongliu SunXiuling ZhouCuiling ZhouHongyu ZhangZhibin ChengHaiqing MaHuanhuan SunNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shuncong Wang Jianjun Tang Tiantian Sun Xiaobin Zheng Jie Li Hongliu Sun Xiuling Zhou Cuiling Zhou Hongyu Zhang Zhibin Cheng Haiqing Ma Huanhuan Sun Survival changes in patients with small cell lung cancer and disparities between different sexes, socioeconomic statuses and ages
description	Abstract Small cell lung cancer (SCLC), as a proportion, makes up only 15–17% of lung cancer cases. The development of treatments for SCLC has remained stagnant for decades, and SCLC is expected to persist as a threat to human health. To date, no publications based on large populations have been reported. We calculated survival changes in patients with SCLC during each decade between 1983 and 2012 to determine the roles of race, sex, age, and socioeconomic status (SES) on survival rates based on the Surveillance, Epidemiology, and End Results (SEER) registries. In total, 106,296 patients with SCLC were identified, with the overall incidence per 100,000 decreasing each decade from 9.6 to 7.8 to 5.8. The median survival for SCLC remained 7 months, and the 12-month relative survival rates (RSRs) remained relatively stable at 32.9%, 33.2% and 33.2% during each decade. The 5-year RSRs significantly improved from 4.9% to 5.9% to 6.4% during each decade, but remained extremely low. In addition, a narrowing of the survival gaps among SES groups and stable survival gaps between sexes were observed. Although the incidence of SCLC decreased during each decade, the overall survival remained relatively stable, highlighting the urgency of developing novel treatments and the importance of prevention and early detection.
format	article
author	Shuncong Wang Jianjun Tang Tiantian Sun Xiaobin Zheng Jie Li Hongliu Sun Xiuling Zhou Cuiling Zhou Hongyu Zhang Zhibin Cheng Haiqing Ma Huanhuan Sun
author_facet	Shuncong Wang Jianjun Tang Tiantian Sun Xiaobin Zheng Jie Li Hongliu Sun Xiuling Zhou Cuiling Zhou Hongyu Zhang Zhibin Cheng Haiqing Ma Huanhuan Sun
author_sort	Shuncong Wang
title	Survival changes in patients with small cell lung cancer and disparities between different sexes, socioeconomic statuses and ages
title_short	Survival changes in patients with small cell lung cancer and disparities between different sexes, socioeconomic statuses and ages
title_full	Survival changes in patients with small cell lung cancer and disparities between different sexes, socioeconomic statuses and ages
title_fullStr	Survival changes in patients with small cell lung cancer and disparities between different sexes, socioeconomic statuses and ages
title_full_unstemmed	Survival changes in patients with small cell lung cancer and disparities between different sexes, socioeconomic statuses and ages
title_sort	survival changes in patients with small cell lung cancer and disparities between different sexes, socioeconomic statuses and ages
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e89779411d734d8199d2f1a54c1172c6
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Survival changes in patients with small cell lung cancer and disparities between different sexes, socioeconomic statuses and ages

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