Walnut Kernel administration to mothers during pregnancy and lactation improve learning of their pups. Changes in number of neurons and gene expression of NMDA receptor and BDNF in hippocampus in 80 days rat pups

Walnut (Juglans regia) from the Juglandaceae family contains high levels of omega 3 fatty acid, vitamin E and melatonin, hence its consumption is beneficial to would be mothers and their offspring. The current study was designed to determine the possible mechanism of walnut consumption by mothers du...

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Autores principales:	Mahmoodian Zahra, Shekaari Majid Asadi, Soleimani Mansooreh, Ahmadi-Zeidabadi Meysam, Moradi Fatemeh, Akbarnejad Zeinab, Esmaeilpour Khadijeh, Kalantaripour Taj Pri
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2020
Materias:	rat memory walnut learning bdnf nmda-r offspring Medicine R
Acceso en línea:	https://doaj.org/article/e898b6c38f854ab3a9cb964287d89048
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spelling	oai:doaj.org-article:e898b6c38f854ab3a9cb964287d890482021-12-05T14:11:06ZWalnut Kernel administration to mothers during pregnancy and lactation improve learning of their pups. Changes in number of neurons and gene expression of NMDA receptor and BDNF in hippocampus in 80 days rat pups2300-667610.2478/cipms-2020-0031https://doaj.org/article/e898b6c38f854ab3a9cb964287d890482020-12-01T00:00:00Zhttps://doi.org/10.2478/cipms-2020-0031https://doaj.org/toc/2300-6676Walnut (Juglans regia) from the Juglandaceae family contains high levels of omega 3 fatty acid, vitamin E and melatonin, hence its consumption is beneficial to would be mothers and their offspring. The current study was designed to determine the possible mechanism of walnut consumption by mothers during pregnancy and lactation and the positive effects on learning and memory processes in their offspring. Wistar adult female rats were placed into three groups: control (fed with pellet, 20 g daily during pregnancy and lactation), CASE 1 [fed with Walnut Kernel (WK) 6% of food intake during pregnancy and lactation] and CASE 2 (fed with WK, 9% of food intake during gestation and lactation). In order to evaluate offspring learning and memory, the Morris Water Maze (MWM) test was performed for their adult offspring at 80 days of age. Histological and molecular studies were utilized in order to discover the protective mechanism and efficacy of WK consumption. The results revealed that learning was significantly improved in the females of CASE 2, in comparison to controls, while there was no difference in memory among the different groups. In addition, the number of neurons significantly increased in the CASE 2 group compared to the control group. However, the molecular study demonstrated that there was no significant difference among the study groups. The results herein show that feeding mothers with WK may improve the learning competence of their pups and increase the number of neurons in both sexes.Mahmoodian ZahraShekaari Majid AsadiSoleimani MansoorehAhmadi-Zeidabadi MeysamMoradi FatemehAkbarnejad ZeinabEsmaeilpour KhadijehKalantaripour Taj PriSciendoarticleratmemorywalnutlearningbdnfnmda-roffspringMedicineRENCurrent Issues in Pharmacy and Medical Sciences, Vol 33, Iss 4, Pp 219-224 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	rat memory walnut learning bdnf nmda-r offspring Medicine R
spellingShingle	rat memory walnut learning bdnf nmda-r offspring Medicine R Mahmoodian Zahra Shekaari Majid Asadi Soleimani Mansooreh Ahmadi-Zeidabadi Meysam Moradi Fatemeh Akbarnejad Zeinab Esmaeilpour Khadijeh Kalantaripour Taj Pri Walnut Kernel administration to mothers during pregnancy and lactation improve learning of their pups. Changes in number of neurons and gene expression of NMDA receptor and BDNF in hippocampus in 80 days rat pups
description	Walnut (Juglans regia) from the Juglandaceae family contains high levels of omega 3 fatty acid, vitamin E and melatonin, hence its consumption is beneficial to would be mothers and their offspring. The current study was designed to determine the possible mechanism of walnut consumption by mothers during pregnancy and lactation and the positive effects on learning and memory processes in their offspring. Wistar adult female rats were placed into three groups: control (fed with pellet, 20 g daily during pregnancy and lactation), CASE 1 [fed with Walnut Kernel (WK) 6% of food intake during pregnancy and lactation] and CASE 2 (fed with WK, 9% of food intake during gestation and lactation). In order to evaluate offspring learning and memory, the Morris Water Maze (MWM) test was performed for their adult offspring at 80 days of age. Histological and molecular studies were utilized in order to discover the protective mechanism and efficacy of WK consumption. The results revealed that learning was significantly improved in the females of CASE 2, in comparison to controls, while there was no difference in memory among the different groups. In addition, the number of neurons significantly increased in the CASE 2 group compared to the control group. However, the molecular study demonstrated that there was no significant difference among the study groups. The results herein show that feeding mothers with WK may improve the learning competence of their pups and increase the number of neurons in both sexes.
format	article
author	Mahmoodian Zahra Shekaari Majid Asadi Soleimani Mansooreh Ahmadi-Zeidabadi Meysam Moradi Fatemeh Akbarnejad Zeinab Esmaeilpour Khadijeh Kalantaripour Taj Pri
author_facet	Mahmoodian Zahra Shekaari Majid Asadi Soleimani Mansooreh Ahmadi-Zeidabadi Meysam Moradi Fatemeh Akbarnejad Zeinab Esmaeilpour Khadijeh Kalantaripour Taj Pri
author_sort	Mahmoodian Zahra
title	Walnut Kernel administration to mothers during pregnancy and lactation improve learning of their pups. Changes in number of neurons and gene expression of NMDA receptor and BDNF in hippocampus in 80 days rat pups
title_short	Walnut Kernel administration to mothers during pregnancy and lactation improve learning of their pups. Changes in number of neurons and gene expression of NMDA receptor and BDNF in hippocampus in 80 days rat pups
title_full	Walnut Kernel administration to mothers during pregnancy and lactation improve learning of their pups. Changes in number of neurons and gene expression of NMDA receptor and BDNF in hippocampus in 80 days rat pups
title_fullStr	Walnut Kernel administration to mothers during pregnancy and lactation improve learning of their pups. Changes in number of neurons and gene expression of NMDA receptor and BDNF in hippocampus in 80 days rat pups
title_full_unstemmed	Walnut Kernel administration to mothers during pregnancy and lactation improve learning of their pups. Changes in number of neurons and gene expression of NMDA receptor and BDNF in hippocampus in 80 days rat pups
title_sort	walnut kernel administration to mothers during pregnancy and lactation improve learning of their pups. changes in number of neurons and gene expression of nmda receptor and bdnf in hippocampus in 80 days rat pups
publisher	Sciendo
publishDate	2020
url	https://doaj.org/article/e898b6c38f854ab3a9cb964287d89048
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Walnut Kernel administration to mothers during pregnancy and lactation improve learning of their pups. Changes in number of neurons and gene expression of NMDA receptor and BDNF in hippocampus in 80 days rat pups

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