Molecular epidemiology of a Pseudomonas aeruginosa hospital outbreak driven by a contaminated disinfectant-soap dispenser.

<h4>Background and objective</h4>Pseudomonas aeruginosa infection represents a main cause of morbidity and mortality among immunocompromised patients. This study describes a fatal epidemic of P. aeruginosa that occurred in a hematology unit in Italy.<h4>Methods</h4>Retrospect...

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Autores principales:	Simone Lanini, Silvia D'Arezzo, Vincenzo Puro, Lorena Martini, Francesco Imperi, Pierluca Piselli, Marco Montanaro, Simonetta Paoletti, Paolo Visca, Giuseppe Ippolito
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e8996fca572c4b5691ee4d213852a75f
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spelling	oai:doaj.org-article:e8996fca572c4b5691ee4d213852a75f2021-11-18T06:58:40ZMolecular epidemiology of a Pseudomonas aeruginosa hospital outbreak driven by a contaminated disinfectant-soap dispenser.1932-620310.1371/journal.pone.0017064https://doaj.org/article/e8996fca572c4b5691ee4d213852a75f2011-02-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21359222/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background and objective</h4>Pseudomonas aeruginosa infection represents a main cause of morbidity and mortality among immunocompromised patients. This study describes a fatal epidemic of P. aeruginosa that occurred in a hematology unit in Italy.<h4>Methods</h4>Retrospective cohort study, prospective surveillance, auditing, extensive testing on healthcare workers and environmental investigation were performed to define the dynamics and potential causes of transmission. RAPD, macrorestriction analyses and sequence typing were used to define relationships between P. aeruginosa isolates.<h4>Results</h4>Eighteen cases of infection were identified in the different phases of the investigation. Of these, five constitute a significant molecular cluster of infection. A P. aeruginosa strain with the same genetic fingerprint and sequence type (ST175) as clinical isolates strain was also isolated from a heavily contaminated triclosan soap dispenser.<h4>Discussion and conclusions</h4>Our results are consistent with the hypothesis that patients became indirectly infected, e.g., during central venous catheter handling through contaminated items, and that the triclosan soap dispenser acted as a common continuous source of P. aeruginosa infection. Since P. aeruginosa is intrinsically unsusceptible to triclosan, the use of triclosan-based disinfectant formulations should be avoided in those healthcare settings hosting patients at high risk of P. aeruginosa infection.Simone LaniniSilvia D'ArezzoVincenzo PuroLorena MartiniFrancesco ImperiPierluca PiselliMarco MontanaroSimonetta PaolettiPaolo ViscaGiuseppe IppolitoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 2, p e17064 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Simone Lanini Silvia D'Arezzo Vincenzo Puro Lorena Martini Francesco Imperi Pierluca Piselli Marco Montanaro Simonetta Paoletti Paolo Visca Giuseppe Ippolito Molecular epidemiology of a Pseudomonas aeruginosa hospital outbreak driven by a contaminated disinfectant-soap dispenser.
description	<h4>Background and objective</h4>Pseudomonas aeruginosa infection represents a main cause of morbidity and mortality among immunocompromised patients. This study describes a fatal epidemic of P. aeruginosa that occurred in a hematology unit in Italy.<h4>Methods</h4>Retrospective cohort study, prospective surveillance, auditing, extensive testing on healthcare workers and environmental investigation were performed to define the dynamics and potential causes of transmission. RAPD, macrorestriction analyses and sequence typing were used to define relationships between P. aeruginosa isolates.<h4>Results</h4>Eighteen cases of infection were identified in the different phases of the investigation. Of these, five constitute a significant molecular cluster of infection. A P. aeruginosa strain with the same genetic fingerprint and sequence type (ST175) as clinical isolates strain was also isolated from a heavily contaminated triclosan soap dispenser.<h4>Discussion and conclusions</h4>Our results are consistent with the hypothesis that patients became indirectly infected, e.g., during central venous catheter handling through contaminated items, and that the triclosan soap dispenser acted as a common continuous source of P. aeruginosa infection. Since P. aeruginosa is intrinsically unsusceptible to triclosan, the use of triclosan-based disinfectant formulations should be avoided in those healthcare settings hosting patients at high risk of P. aeruginosa infection.
format	article
author	Simone Lanini Silvia D'Arezzo Vincenzo Puro Lorena Martini Francesco Imperi Pierluca Piselli Marco Montanaro Simonetta Paoletti Paolo Visca Giuseppe Ippolito
author_facet	Simone Lanini Silvia D'Arezzo Vincenzo Puro Lorena Martini Francesco Imperi Pierluca Piselli Marco Montanaro Simonetta Paoletti Paolo Visca Giuseppe Ippolito
author_sort	Simone Lanini
title	Molecular epidemiology of a Pseudomonas aeruginosa hospital outbreak driven by a contaminated disinfectant-soap dispenser.
title_short	Molecular epidemiology of a Pseudomonas aeruginosa hospital outbreak driven by a contaminated disinfectant-soap dispenser.
title_full	Molecular epidemiology of a Pseudomonas aeruginosa hospital outbreak driven by a contaminated disinfectant-soap dispenser.
title_fullStr	Molecular epidemiology of a Pseudomonas aeruginosa hospital outbreak driven by a contaminated disinfectant-soap dispenser.
title_full_unstemmed	Molecular epidemiology of a Pseudomonas aeruginosa hospital outbreak driven by a contaminated disinfectant-soap dispenser.
title_sort	molecular epidemiology of a pseudomonas aeruginosa hospital outbreak driven by a contaminated disinfectant-soap dispenser.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/e8996fca572c4b5691ee4d213852a75f
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Molecular epidemiology of a Pseudomonas aeruginosa hospital outbreak driven by a contaminated disinfectant-soap dispenser.

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