Malfunctioning CD106-positive, short-term hematopoietic stem cells trigger diabetic neuropathy in mice by cell fusion

Malfunctioning CD106-positive, short-term hematopoietic stem cells trigger diabetic neuropathy in mice by cell fusion

Katagi et al. show that abnormal bone marrow-derived cells originated from hematopoietic stem cells (CD106-positive short-term HSCs) aberrantly fuse with neurons to develop diabetic neuropathy. This study suggests that the pathological abnormality is memorized in the bone marrow and that it cannot b...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Miwako Katagi, Tomoya Terashima, Natsuko Ohashi, Yuki Nakae, Akane Yamada, Takahiko Nakagawa, Itsuko Miyazawa, Hiroshi Maegawa, Junko Okano, Yoshihisa Suzuki, Kazunori Fujino, Yutaka Eguchi, Hideto Kojima
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/e89bf4e21fc54a66a503dcaba1d6baae
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:e89bf4e21fc54a66a503dcaba1d6baae
record_format dspace
spelling oai:doaj.org-article:e89bf4e21fc54a66a503dcaba1d6baae2021-12-02T15:55:21ZMalfunctioning CD106-positive, short-term hematopoietic stem cells trigger diabetic neuropathy in mice by cell fusion10.1038/s42003-021-02082-52399-3642https://doaj.org/article/e89bf4e21fc54a66a503dcaba1d6baae2021-05-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02082-5https://doaj.org/toc/2399-3642Katagi et al. show that abnormal bone marrow-derived cells originated from hematopoietic stem cells (CD106-positive short-term HSCs) aberrantly fuse with neurons to develop diabetic neuropathy. This study suggests that the pathological abnormality is memorized in the bone marrow and that it cannot be erased by conventional therapy.Miwako KatagiTomoya TerashimaNatsuko OhashiYuki NakaeAkane YamadaTakahiko NakagawaItsuko MiyazawaHiroshi MaegawaJunko OkanoYoshihisa SuzukiKazunori FujinoYutaka EguchiHideto KojimaNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Biology (General)
QH301-705.5
spellingShingle Biology (General)
QH301-705.5
Miwako Katagi
Tomoya Terashima
Natsuko Ohashi
Yuki Nakae
Akane Yamada
Takahiko Nakagawa
Itsuko Miyazawa
Hiroshi Maegawa
Junko Okano
Yoshihisa Suzuki
Kazunori Fujino
Yutaka Eguchi
Hideto Kojima
Malfunctioning CD106-positive, short-term hematopoietic stem cells trigger diabetic neuropathy in mice by cell fusion
description Katagi et al. show that abnormal bone marrow-derived cells originated from hematopoietic stem cells (CD106-positive short-term HSCs) aberrantly fuse with neurons to develop diabetic neuropathy. This study suggests that the pathological abnormality is memorized in the bone marrow and that it cannot be erased by conventional therapy.
format article
author Miwako Katagi
Tomoya Terashima
Natsuko Ohashi
Yuki Nakae
Akane Yamada
Takahiko Nakagawa
Itsuko Miyazawa
Hiroshi Maegawa
Junko Okano
Yoshihisa Suzuki
Kazunori Fujino
Yutaka Eguchi
Hideto Kojima
author_facet Miwako Katagi
Tomoya Terashima
Natsuko Ohashi
Yuki Nakae
Akane Yamada
Takahiko Nakagawa
Itsuko Miyazawa
Hiroshi Maegawa
Junko Okano
Yoshihisa Suzuki
Kazunori Fujino
Yutaka Eguchi
Hideto Kojima
author_sort Miwako Katagi
title Malfunctioning CD106-positive, short-term hematopoietic stem cells trigger diabetic neuropathy in mice by cell fusion
title_short Malfunctioning CD106-positive, short-term hematopoietic stem cells trigger diabetic neuropathy in mice by cell fusion
title_full Malfunctioning CD106-positive, short-term hematopoietic stem cells trigger diabetic neuropathy in mice by cell fusion
title_fullStr Malfunctioning CD106-positive, short-term hematopoietic stem cells trigger diabetic neuropathy in mice by cell fusion
title_full_unstemmed Malfunctioning CD106-positive, short-term hematopoietic stem cells trigger diabetic neuropathy in mice by cell fusion
title_sort malfunctioning cd106-positive, short-term hematopoietic stem cells trigger diabetic neuropathy in mice by cell fusion
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/e89bf4e21fc54a66a503dcaba1d6baae
work_keys_str_mv AT miwakokatagi malfunctioningcd106positiveshorttermhematopoieticstemcellstriggerdiabeticneuropathyinmicebycellfusion
AT tomoyaterashima malfunctioningcd106positiveshorttermhematopoieticstemcellstriggerdiabeticneuropathyinmicebycellfusion
AT natsukoohashi malfunctioningcd106positiveshorttermhematopoieticstemcellstriggerdiabeticneuropathyinmicebycellfusion
AT yukinakae malfunctioningcd106positiveshorttermhematopoieticstemcellstriggerdiabeticneuropathyinmicebycellfusion
AT akaneyamada malfunctioningcd106positiveshorttermhematopoieticstemcellstriggerdiabeticneuropathyinmicebycellfusion
AT takahikonakagawa malfunctioningcd106positiveshorttermhematopoieticstemcellstriggerdiabeticneuropathyinmicebycellfusion
AT itsukomiyazawa malfunctioningcd106positiveshorttermhematopoieticstemcellstriggerdiabeticneuropathyinmicebycellfusion
AT hiroshimaegawa malfunctioningcd106positiveshorttermhematopoieticstemcellstriggerdiabeticneuropathyinmicebycellfusion
AT junkookano malfunctioningcd106positiveshorttermhematopoieticstemcellstriggerdiabeticneuropathyinmicebycellfusion
AT yoshihisasuzuki malfunctioningcd106positiveshorttermhematopoieticstemcellstriggerdiabeticneuropathyinmicebycellfusion
AT kazunorifujino malfunctioningcd106positiveshorttermhematopoieticstemcellstriggerdiabeticneuropathyinmicebycellfusion
AT yutakaeguchi malfunctioningcd106positiveshorttermhematopoieticstemcellstriggerdiabeticneuropathyinmicebycellfusion
AT hidetokojima malfunctioningcd106positiveshorttermhematopoieticstemcellstriggerdiabeticneuropathyinmicebycellfusion
_version_ 1718385424576020480

Ejemplares similares