Hypoxia-induced mobilization of NHE6 to the plasma membrane triggers endosome hyperacidification and chemoresistance

Sodium/proton exchangers (NHEs) are critical regulators of pH within the cell and the extracellular microenvironment. Here, the authors show that hypoxia induces mobilization of NHE6 from endosomal compartment to the plasma membrane in a PKC-dependent manner inducing hyper acidification of endosomes...

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Autores principales:	Fabrice Lucien, Pierre-Paul Pelletier, Roxane R. Lavoie, Jean-Michel Lacroix, Sébastien Roy, Jean-Luc Parent, Dominique Arsenault, Kelly Harper, Claire M. Dubois
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e89f4976e6c8410083340eff97f54108
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spelling	oai:doaj.org-article:e89f4976e6c8410083340eff97f541082021-12-02T17:06:05ZHypoxia-induced mobilization of NHE6 to the plasma membrane triggers endosome hyperacidification and chemoresistance10.1038/ncomms158842041-1723https://doaj.org/article/e89f4976e6c8410083340eff97f541082017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15884https://doaj.org/toc/2041-1723Sodium/proton exchangers (NHEs) are critical regulators of pH within the cell and the extracellular microenvironment. Here, the authors show that hypoxia induces mobilization of NHE6 from endosomal compartment to the plasma membrane in a PKC-dependent manner inducing hyper acidification of endosomes and drug resistance.Fabrice LucienPierre-Paul PelletierRoxane R. LavoieJean-Michel LacroixSébastien RoyJean-Luc ParentDominique ArsenaultKelly HarperClaire M. DuboisNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fabrice Lucien Pierre-Paul Pelletier Roxane R. Lavoie Jean-Michel Lacroix Sébastien Roy Jean-Luc Parent Dominique Arsenault Kelly Harper Claire M. Dubois Hypoxia-induced mobilization of NHE6 to the plasma membrane triggers endosome hyperacidification and chemoresistance
description	Sodium/proton exchangers (NHEs) are critical regulators of pH within the cell and the extracellular microenvironment. Here, the authors show that hypoxia induces mobilization of NHE6 from endosomal compartment to the plasma membrane in a PKC-dependent manner inducing hyper acidification of endosomes and drug resistance.
format	article
author	Fabrice Lucien Pierre-Paul Pelletier Roxane R. Lavoie Jean-Michel Lacroix Sébastien Roy Jean-Luc Parent Dominique Arsenault Kelly Harper Claire M. Dubois
author_facet	Fabrice Lucien Pierre-Paul Pelletier Roxane R. Lavoie Jean-Michel Lacroix Sébastien Roy Jean-Luc Parent Dominique Arsenault Kelly Harper Claire M. Dubois
author_sort	Fabrice Lucien
title	Hypoxia-induced mobilization of NHE6 to the plasma membrane triggers endosome hyperacidification and chemoresistance
title_short	Hypoxia-induced mobilization of NHE6 to the plasma membrane triggers endosome hyperacidification and chemoresistance
title_full	Hypoxia-induced mobilization of NHE6 to the plasma membrane triggers endosome hyperacidification and chemoresistance
title_fullStr	Hypoxia-induced mobilization of NHE6 to the plasma membrane triggers endosome hyperacidification and chemoresistance
title_full_unstemmed	Hypoxia-induced mobilization of NHE6 to the plasma membrane triggers endosome hyperacidification and chemoresistance
title_sort	hypoxia-induced mobilization of nhe6 to the plasma membrane triggers endosome hyperacidification and chemoresistance
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e89f4976e6c8410083340eff97f54108
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Hypoxia-induced mobilization of NHE6 to the plasma membrane triggers endosome hyperacidification and chemoresistance

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