Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil

Omecamtiv mecarbil (OM) is a cardiac myosin activator that is currently in clinical trials for heart failure treatment. Here, the authors give insights into its mode of action and present the crystal structure of OM bound to bovine cardiac myosin, which shows that OM stabilizes the pre-powerstroke s...

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Autores principales:	Vicente J. Planelles-Herrero, James J. Hartman, Julien Robert-Paganin, Fady I. Malik, Anne Houdusse
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e89f50badcf146dca49a24d78e0e1fa7
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spelling	oai:doaj.org-article:e89f50badcf146dca49a24d78e0e1fa72021-12-02T13:27:22ZMechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil10.1038/s41467-017-00176-52041-1723https://doaj.org/article/e89f50badcf146dca49a24d78e0e1fa72017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00176-5https://doaj.org/toc/2041-1723Omecamtiv mecarbil (OM) is a cardiac myosin activator that is currently in clinical trials for heart failure treatment. Here, the authors give insights into its mode of action and present the crystal structure of OM bound to bovine cardiac myosin, which shows that OM stabilizes the pre-powerstroke state of myosin.Vicente J. Planelles-HerreroJames J. HartmanJulien Robert-PaganinFady I. MalikAnne HoudusseNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Vicente J. Planelles-Herrero James J. Hartman Julien Robert-Paganin Fady I. Malik Anne Houdusse Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil
description	Omecamtiv mecarbil (OM) is a cardiac myosin activator that is currently in clinical trials for heart failure treatment. Here, the authors give insights into its mode of action and present the crystal structure of OM bound to bovine cardiac myosin, which shows that OM stabilizes the pre-powerstroke state of myosin.
format	article
author	Vicente J. Planelles-Herrero James J. Hartman Julien Robert-Paganin Fady I. Malik Anne Houdusse
author_facet	Vicente J. Planelles-Herrero James J. Hartman Julien Robert-Paganin Fady I. Malik Anne Houdusse
author_sort	Vicente J. Planelles-Herrero
title	Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil
title_short	Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil
title_full	Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil
title_fullStr	Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil
title_full_unstemmed	Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil
title_sort	mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e89f50badcf146dca49a24d78e0e1fa7
work_keys_str_mv	AT vicentejplanellesherrero mechanisticandstructuralbasisforactivationofcardiacmyosinforceproductionbyomecamtivmecarbil AT jamesjhartman mechanisticandstructuralbasisforactivationofcardiacmyosinforceproductionbyomecamtivmecarbil AT julienrobertpaganin mechanisticandstructuralbasisforactivationofcardiacmyosinforceproductionbyomecamtivmecarbil AT fadyimalik mechanisticandstructuralbasisforactivationofcardiacmyosinforceproductionbyomecamtivmecarbil AT annehoudusse mechanisticandstructuralbasisforactivationofcardiacmyosinforceproductionbyomecamtivmecarbil
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Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil

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