Fabrication of transparent hemispherical 3D nanofibrous scaffolds with radially aligned patterns via a novel electrospinning method

Abstract Tissue engineering has significantly contributed to the development of optimal treatments for individual injury sites based on their unique functional and histologic properties. Human organs and tissue have three-dimensional (3D) morphologies; for example, the morphology of the eye is a sph...

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Autores principales:	Jeong In Kim, Ju Yeon Kim, Chan Hee Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e8a246cbf8634bacbad8de767b102dc9
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spelling	oai:doaj.org-article:e8a246cbf8634bacbad8de767b102dc92021-12-02T11:40:36ZFabrication of transparent hemispherical 3D nanofibrous scaffolds with radially aligned patterns via a novel electrospinning method10.1038/s41598-018-21618-02045-2322https://doaj.org/article/e8a246cbf8634bacbad8de767b102dc92018-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-21618-0https://doaj.org/toc/2045-2322Abstract Tissue engineering has significantly contributed to the development of optimal treatments for individual injury sites based on their unique functional and histologic properties. Human organs and tissue have three-dimensional (3D) morphologies; for example, the morphology of the eye is a spherical shape. However, most conventional electrospinning equipment is only capable of fabricating a two-dimensional (2D) structured fibrous scaffold and no report is available on a 3D electrospinning method to fabricate a hemispherical scaffold to mimic the native properties of the cornea, including microscopic to macroscopic morphology and transparency. We proposed a novel electrospinning method using a single nonconductive hemispherical device and a metal pin. A designed peg-top shaped collector, a hemispherical nonconductive device with a metal pin in the center and copper wire forming a circle around at the edge was attached to a conventional conductive collector. A 3D hemispherical transparent scaffold with radially aligned nanofibers was successfully fabricated with the designed peg-top collector. In summary, our fabricated 3D electrospun scaffold is expected to be suitable for the treatment of injuries of ocular tissues owing to the hemispherical shape and radially aligned nanofibers which can guide the direction of the main collagen and cellular actin filament in the extracellular matrix.Jeong In KimJu Yeon KimChan Hee ParkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jeong In Kim Ju Yeon Kim Chan Hee Park Fabrication of transparent hemispherical 3D nanofibrous scaffolds with radially aligned patterns via a novel electrospinning method
description	Abstract Tissue engineering has significantly contributed to the development of optimal treatments for individual injury sites based on their unique functional and histologic properties. Human organs and tissue have three-dimensional (3D) morphologies; for example, the morphology of the eye is a spherical shape. However, most conventional electrospinning equipment is only capable of fabricating a two-dimensional (2D) structured fibrous scaffold and no report is available on a 3D electrospinning method to fabricate a hemispherical scaffold to mimic the native properties of the cornea, including microscopic to macroscopic morphology and transparency. We proposed a novel electrospinning method using a single nonconductive hemispherical device and a metal pin. A designed peg-top shaped collector, a hemispherical nonconductive device with a metal pin in the center and copper wire forming a circle around at the edge was attached to a conventional conductive collector. A 3D hemispherical transparent scaffold with radially aligned nanofibers was successfully fabricated with the designed peg-top collector. In summary, our fabricated 3D electrospun scaffold is expected to be suitable for the treatment of injuries of ocular tissues owing to the hemispherical shape and radially aligned nanofibers which can guide the direction of the main collagen and cellular actin filament in the extracellular matrix.
format	article
author	Jeong In Kim Ju Yeon Kim Chan Hee Park
author_facet	Jeong In Kim Ju Yeon Kim Chan Hee Park
author_sort	Jeong In Kim
title	Fabrication of transparent hemispherical 3D nanofibrous scaffolds with radially aligned patterns via a novel electrospinning method
title_short	Fabrication of transparent hemispherical 3D nanofibrous scaffolds with radially aligned patterns via a novel electrospinning method
title_full	Fabrication of transparent hemispherical 3D nanofibrous scaffolds with radially aligned patterns via a novel electrospinning method
title_fullStr	Fabrication of transparent hemispherical 3D nanofibrous scaffolds with radially aligned patterns via a novel electrospinning method
title_full_unstemmed	Fabrication of transparent hemispherical 3D nanofibrous scaffolds with radially aligned patterns via a novel electrospinning method
title_sort	fabrication of transparent hemispherical 3d nanofibrous scaffolds with radially aligned patterns via a novel electrospinning method
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e8a246cbf8634bacbad8de767b102dc9
work_keys_str_mv	AT jeonginkim fabricationoftransparenthemispherical3dnanofibrousscaffoldswithradiallyalignedpatternsviaanovelelectrospinningmethod AT juyeonkim fabricationoftransparenthemispherical3dnanofibrousscaffoldswithradiallyalignedpatternsviaanovelelectrospinningmethod AT chanheepark fabricationoftransparenthemispherical3dnanofibrousscaffoldswithradiallyalignedpatternsviaanovelelectrospinningmethod
_version_	1718395614416338944

Fabrication of transparent hemispherical 3D nanofibrous scaffolds with radially aligned patterns via a novel electrospinning method

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