Bacterial Whack-a-Mole: Reconsidering the Public Health Relevance of Using Carbadox in Food Animals

ABSTRACT Carbadox is an antibiotic used to control dysentery and promote growth in swine in the United States; however, the drug also causes tumors and birth defects in laboratory animals. Despite this and because the drug has no analogs in human medicine, it is not considered “medically important”...

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Autor principal:	Lance B. Price
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2017
Materias:	agriculture antibiotic antibiotic resistance antimicrobial carbadox health policy Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/e8a4f2d9591c408381d0f2d2d44b4923
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spelling	oai:doaj.org-article:e8a4f2d9591c408381d0f2d2d44b49232021-11-15T15:51:52ZBacterial Whack-a-Mole: Reconsidering the Public Health Relevance of Using Carbadox in Food Animals10.1128/mBio.01490-172150-7511https://doaj.org/article/e8a4f2d9591c408381d0f2d2d44b49232017-11-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01490-17https://doaj.org/toc/2150-7511ABSTRACT Carbadox is an antibiotic used to control dysentery and promote growth in swine in the United States; however, the drug also causes tumors and birth defects in laboratory animals. Despite this and because the drug has no analogs in human medicine, it is not considered “medically important” and can be used in livestock without veterinarian oversight. In their recent study, T. A. Johnson et al. (mBio 8:e00709-17, 2017, https://doi.org/10.1128/mBio.00709-17 ) demonstrated that carbadox has profound effects on the swine gut microbiome, including the induction of transducing phage carrying tetracycline, aminoglycoside, and beta-lactam resistance genes. In swine production, carbadox can be used in conjunction with other antibiotics (e.g., oxytetracycline) that could fuel the emergence of strains carrying phage-encoded resistance determinants. Johnson et al.’s findings underscore the potential unforeseen consequences of using antibiotics in livestock production and call into question our current methods for classifying whether or not a veterinary drug has relevance to human health.Lance B. PriceAmerican Society for Microbiologyarticleagricultureantibioticantibiotic resistanceantimicrobialcarbadoxhealth policyMicrobiologyQR1-502ENmBio, Vol 8, Iss 5 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	agriculture antibiotic antibiotic resistance antimicrobial carbadox health policy Microbiology QR1-502
spellingShingle	agriculture antibiotic antibiotic resistance antimicrobial carbadox health policy Microbiology QR1-502 Lance B. Price Bacterial Whack-a-Mole: Reconsidering the Public Health Relevance of Using Carbadox in Food Animals
description	ABSTRACT Carbadox is an antibiotic used to control dysentery and promote growth in swine in the United States; however, the drug also causes tumors and birth defects in laboratory animals. Despite this and because the drug has no analogs in human medicine, it is not considered “medically important” and can be used in livestock without veterinarian oversight. In their recent study, T. A. Johnson et al. (mBio 8:e00709-17, 2017, https://doi.org/10.1128/mBio.00709-17 ) demonstrated that carbadox has profound effects on the swine gut microbiome, including the induction of transducing phage carrying tetracycline, aminoglycoside, and beta-lactam resistance genes. In swine production, carbadox can be used in conjunction with other antibiotics (e.g., oxytetracycline) that could fuel the emergence of strains carrying phage-encoded resistance determinants. Johnson et al.’s findings underscore the potential unforeseen consequences of using antibiotics in livestock production and call into question our current methods for classifying whether or not a veterinary drug has relevance to human health.
format	article
author	Lance B. Price
author_facet	Lance B. Price
author_sort	Lance B. Price
title	Bacterial Whack-a-Mole: Reconsidering the Public Health Relevance of Using Carbadox in Food Animals
title_short	Bacterial Whack-a-Mole: Reconsidering the Public Health Relevance of Using Carbadox in Food Animals
title_full	Bacterial Whack-a-Mole: Reconsidering the Public Health Relevance of Using Carbadox in Food Animals
title_fullStr	Bacterial Whack-a-Mole: Reconsidering the Public Health Relevance of Using Carbadox in Food Animals
title_full_unstemmed	Bacterial Whack-a-Mole: Reconsidering the Public Health Relevance of Using Carbadox in Food Animals
title_sort	bacterial whack-a-mole: reconsidering the public health relevance of using carbadox in food animals
publisher	American Society for Microbiology
publishDate	2017
url	https://doaj.org/article/e8a4f2d9591c408381d0f2d2d44b4923
work_keys_str_mv	AT lancebprice bacterialwhackamolereconsideringthepublichealthrelevanceofusingcarbadoxinfoodanimals
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Bacterial Whack-a-Mole: Reconsidering the Public Health Relevance of Using Carbadox in Food Animals

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