A Stronger Association of Epicardial Fat Volume with Non-Valvular Atrial Fibrillation Than Measures of General Obesity in Chinese Patients Undergoing Computed Tomography Coronary Angiography
Jingqi Zhu,1,2,* Zhangwei Yang,2,* Xiaoli Chen,3,* Jie Liu,3 Liang Zheng,3 Lin Zhang,3 Jingjiang Pi,4 Gang Li,2 Tao Zhuang,3 Chang Liu,3 Yinglu Wang,3 Liping Liu,3 Lieying Fan,5 Paul Chan,6 Brian Tomlinson,7 Ying Li,4 Zhongmin Liu,3 Yuzhen Zhang3 1Department of Radiology, Shanghai Tenth People&r...
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Dove Medical Press
2021
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atrial fibrillation epicardial fat pericardial fat obesity body mass index computed tomography echocardiography Specialties of internal medicine RC581-951 |
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atrial fibrillation epicardial fat pericardial fat obesity body mass index computed tomography echocardiography Specialties of internal medicine RC581-951 Zhu J Yang Z Chen X Liu J Zheng L Zhang L Pi J Li G Zhuang T Liu C Wang Y Liu L Fan L Chan P Tomlinson B Li Y Liu Z Zhang Y A Stronger Association of Epicardial Fat Volume with Non-Valvular Atrial Fibrillation Than Measures of General Obesity in Chinese Patients Undergoing Computed Tomography Coronary Angiography |
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Jingqi Zhu,1,2,* Zhangwei Yang,2,* Xiaoli Chen,3,* Jie Liu,3 Liang Zheng,3 Lin Zhang,3 Jingjiang Pi,4 Gang Li,2 Tao Zhuang,3 Chang Liu,3 Yinglu Wang,3 Liping Liu,3 Lieying Fan,5 Paul Chan,6 Brian Tomlinson,7 Ying Li,4 Zhongmin Liu,3 Yuzhen Zhang3 1Department of Radiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China; 2Department of Radiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China; 3Key Laboratory of Arrhythmias of the Ministry of Education of China, Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China; 4Department of Cardiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China; 5Department of Clinical Laboratory, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China; 6Division of Cardiology, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; 7Faculty of Medicine, Macau University of Science and Technology, Macau, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yuzhen Zhang; Zhongmin LiuKey Laboratory of Arrhythmias of the Ministry of Education of China, Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, 150 Jimo Road, Pudong New District, Shanghai, 200120, People’s Republic of ChinaTel +86-21-61569673Email yzzhang-tj@tongji.edu.cn; liu.zhongmin@tongji.edu.cnObjective: An association of atrial fibrillation (AF) with epicardial fat volume (EFV) varied in different ethnic groups. We evaluated the AF-related risk factors and its association with pericardial fat in Chinese patients.Methods: Patients referred for coronary computed tomography angiography (CCTA) in Shanghai East Hospital during 2012 to 2014 (n=2042, 43.8% women, mean age 65.0 years) had AF and cardiovascular risk assessment. Pericardial fat depots were measured from CT and the association of EFV with non-valvular AF risk factors was evaluated by multivariate logistic regression models.Results: AF was present in 8.5% of patients with 11.6% of AF patients having rheumatic heart disease (RHD) and 8.7% having other valvular diseases. With increasing age, the proportion of RHD-related AF decreased and the risk factors for non-valvular AF increased. There was a significantly higher proportion of risk factors for non-valvular AF in men than in women (p=0.008), but RHD-related AF was more prevalent in women than men (p=0.013). The patients with non-valvular AF had significantly higher BMI and EFV with more pronounced elevation of EFV (p< 0.001). Multivariate logistic regression showed a significant association of EFV with AF after adjustment for BMI and clinical risk factors, and the highest EFV quartile was associated with AF independent of left atrial size and obstructive coronary artery disease.Conclusion: The association of EFV with non-valvular AF in Chinese patients was independent of generalized adiposity and clinical risk factors especially in highest EFV quartile. These findings support the growing appreciation of the association of EFV with AF.Keywords: atrial fibrillation, epicardial fat, pericardial fat, obesity, body mass index, computed tomography, echocardiography |
| format |
article |
| author |
Zhu J Yang Z Chen X Liu J Zheng L Zhang L Pi J Li G Zhuang T Liu C Wang Y Liu L Fan L Chan P Tomlinson B Li Y Liu Z Zhang Y |
| author_facet |
Zhu J Yang Z Chen X Liu J Zheng L Zhang L Pi J Li G Zhuang T Liu C Wang Y Liu L Fan L Chan P Tomlinson B Li Y Liu Z Zhang Y |
| author_sort |
Zhu J |
| title |
A Stronger Association of Epicardial Fat Volume with Non-Valvular Atrial Fibrillation Than Measures of General Obesity in Chinese Patients Undergoing Computed Tomography Coronary Angiography |
| title_short |
A Stronger Association of Epicardial Fat Volume with Non-Valvular Atrial Fibrillation Than Measures of General Obesity in Chinese Patients Undergoing Computed Tomography Coronary Angiography |
| title_full |
A Stronger Association of Epicardial Fat Volume with Non-Valvular Atrial Fibrillation Than Measures of General Obesity in Chinese Patients Undergoing Computed Tomography Coronary Angiography |
| title_fullStr |
A Stronger Association of Epicardial Fat Volume with Non-Valvular Atrial Fibrillation Than Measures of General Obesity in Chinese Patients Undergoing Computed Tomography Coronary Angiography |
| title_full_unstemmed |
A Stronger Association of Epicardial Fat Volume with Non-Valvular Atrial Fibrillation Than Measures of General Obesity in Chinese Patients Undergoing Computed Tomography Coronary Angiography |
| title_sort |
stronger association of epicardial fat volume with non-valvular atrial fibrillation than measures of general obesity in chinese patients undergoing computed tomography coronary angiography |
| publisher |
Dove Medical Press |
| publishDate |
2021 |
| url |
https://doaj.org/article/e8a7b222ec1b4b418582cf1e71d776ab |
| work_keys_str_mv |
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oai:doaj.org-article:e8a7b222ec1b4b418582cf1e71d776ab2021-12-02T11:39:16ZA Stronger Association of Epicardial Fat Volume with Non-Valvular Atrial Fibrillation Than Measures of General Obesity in Chinese Patients Undergoing Computed Tomography Coronary Angiography1178-7007https://doaj.org/article/e8a7b222ec1b4b418582cf1e71d776ab2021-03-01T00:00:00Zhttps://www.dovepress.com/a-stronger-association-of-epicardial-fat-volume-with-non-valvular-atri-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Jingqi Zhu,1,2,* Zhangwei Yang,2,* Xiaoli Chen,3,* Jie Liu,3 Liang Zheng,3 Lin Zhang,3 Jingjiang Pi,4 Gang Li,2 Tao Zhuang,3 Chang Liu,3 Yinglu Wang,3 Liping Liu,3 Lieying Fan,5 Paul Chan,6 Brian Tomlinson,7 Ying Li,4 Zhongmin Liu,3 Yuzhen Zhang3 1Department of Radiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China; 2Department of Radiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China; 3Key Laboratory of Arrhythmias of the Ministry of Education of China, Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China; 4Department of Cardiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China; 5Department of Clinical Laboratory, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China; 6Division of Cardiology, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; 7Faculty of Medicine, Macau University of Science and Technology, Macau, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yuzhen Zhang; Zhongmin LiuKey Laboratory of Arrhythmias of the Ministry of Education of China, Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, 150 Jimo Road, Pudong New District, Shanghai, 200120, People’s Republic of ChinaTel +86-21-61569673Email yzzhang-tj@tongji.edu.cn; liu.zhongmin@tongji.edu.cnObjective: An association of atrial fibrillation (AF) with epicardial fat volume (EFV) varied in different ethnic groups. We evaluated the AF-related risk factors and its association with pericardial fat in Chinese patients.Methods: Patients referred for coronary computed tomography angiography (CCTA) in Shanghai East Hospital during 2012 to 2014 (n=2042, 43.8% women, mean age 65.0 years) had AF and cardiovascular risk assessment. Pericardial fat depots were measured from CT and the association of EFV with non-valvular AF risk factors was evaluated by multivariate logistic regression models.Results: AF was present in 8.5% of patients with 11.6% of AF patients having rheumatic heart disease (RHD) and 8.7% having other valvular diseases. With increasing age, the proportion of RHD-related AF decreased and the risk factors for non-valvular AF increased. There was a significantly higher proportion of risk factors for non-valvular AF in men than in women (p=0.008), but RHD-related AF was more prevalent in women than men (p=0.013). The patients with non-valvular AF had significantly higher BMI and EFV with more pronounced elevation of EFV (p< 0.001). Multivariate logistic regression showed a significant association of EFV with AF after adjustment for BMI and clinical risk factors, and the highest EFV quartile was associated with AF independent of left atrial size and obstructive coronary artery disease.Conclusion: The association of EFV with non-valvular AF in Chinese patients was independent of generalized adiposity and clinical risk factors especially in highest EFV quartile. These findings support the growing appreciation of the association of EFV with AF.Keywords: atrial fibrillation, epicardial fat, pericardial fat, obesity, body mass index, computed tomography, echocardiographyZhu JYang ZChen XLiu JZheng LZhang LPi JLi GZhuang TLiu CWang YLiu LFan LChan PTomlinson BLi YLiu ZZhang YDove Medical Pressarticleatrial fibrillationepicardial fatpericardial fatobesitybody mass indexcomputed tomographyechocardiographySpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 1223-1232 (2021) |