New Mechanism by Which Human Cytomegalovirus MicroRNAs Negate the Proinflammatory Response to Infection

ABSTRACT Viruses have evolved many novel mechanisms to promote infection and to mitigate the host cell response to that infection. In the article by M. H. Hancock et al. (mBio 8:e00109-17, 2017, https://doi.org/10.1128/mBio.00109-17 ), the authors describe a new mechanism by which human cytomegalovi...

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Autor principal:	Andrew D. Yurochko
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2017
Materias:	HCMV IKK NF-κB cytokines human cytomegalovirus miRNA Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/e8a7e69c78b848978e80a3ac3187d5a5
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spelling	oai:doaj.org-article:e8a7e69c78b848978e80a3ac3187d5a52021-11-15T15:51:00ZNew Mechanism by Which Human Cytomegalovirus MicroRNAs Negate the Proinflammatory Response to Infection10.1128/mBio.00505-172150-7511https://doaj.org/article/e8a7e69c78b848978e80a3ac3187d5a52017-05-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00505-17https://doaj.org/toc/2150-7511ABSTRACT Viruses have evolved many novel mechanisms to promote infection and to mitigate the host cell response to that infection. In the article by M. H. Hancock et al. (mBio 8:e00109-17, 2017, https://doi.org/10.1128/mBio.00109-17 ), the authors describe a new mechanism by which human cytomegalovirus (HCMV) microRNAs (miRNAs; miR-US5-1 and miR-UL112-3p) negate the proinflammatory response to infection. The authors document that these two viral miRNAs downregulate the NF-κB response through direct targeting of the IKKα and IKKβ mRNAs, which in turn, through diminished IκB kinases (IKKs), block production of proinflammatory cytokines (interleukin-6 [IL-6], CCL5, and tumor necrosis factor alpha [TNF-α]). Because most signaling pathways that promote NF-κB activation and nuclear translocation ultimately converge on the activation of the IKK complex, this new study documents that HCMV can strongly dictate how infected cells respond to internal and/or external stimuli and thus positively influence the outcome of both lytic and latent infection.Andrew D. YurochkoAmerican Society for MicrobiologyarticleHCMVIKKNF-κBcytokineshuman cytomegalovirusmiRNAMicrobiologyQR1-502ENmBio, Vol 8, Iss 2 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	HCMV IKK NF-κB cytokines human cytomegalovirus miRNA Microbiology QR1-502
spellingShingle	HCMV IKK NF-κB cytokines human cytomegalovirus miRNA Microbiology QR1-502 Andrew D. Yurochko New Mechanism by Which Human Cytomegalovirus MicroRNAs Negate the Proinflammatory Response to Infection
description	ABSTRACT Viruses have evolved many novel mechanisms to promote infection and to mitigate the host cell response to that infection. In the article by M. H. Hancock et al. (mBio 8:e00109-17, 2017, https://doi.org/10.1128/mBio.00109-17 ), the authors describe a new mechanism by which human cytomegalovirus (HCMV) microRNAs (miRNAs; miR-US5-1 and miR-UL112-3p) negate the proinflammatory response to infection. The authors document that these two viral miRNAs downregulate the NF-κB response through direct targeting of the IKKα and IKKβ mRNAs, which in turn, through diminished IκB kinases (IKKs), block production of proinflammatory cytokines (interleukin-6 [IL-6], CCL5, and tumor necrosis factor alpha [TNF-α]). Because most signaling pathways that promote NF-κB activation and nuclear translocation ultimately converge on the activation of the IKK complex, this new study documents that HCMV can strongly dictate how infected cells respond to internal and/or external stimuli and thus positively influence the outcome of both lytic and latent infection.
format	article
author	Andrew D. Yurochko
author_facet	Andrew D. Yurochko
author_sort	Andrew D. Yurochko
title	New Mechanism by Which Human Cytomegalovirus MicroRNAs Negate the Proinflammatory Response to Infection
title_short	New Mechanism by Which Human Cytomegalovirus MicroRNAs Negate the Proinflammatory Response to Infection
title_full	New Mechanism by Which Human Cytomegalovirus MicroRNAs Negate the Proinflammatory Response to Infection
title_fullStr	New Mechanism by Which Human Cytomegalovirus MicroRNAs Negate the Proinflammatory Response to Infection
title_full_unstemmed	New Mechanism by Which Human Cytomegalovirus MicroRNAs Negate the Proinflammatory Response to Infection
title_sort	new mechanism by which human cytomegalovirus micrornas negate the proinflammatory response to infection
publisher	American Society for Microbiology
publishDate	2017
url	https://doaj.org/article/e8a7e69c78b848978e80a3ac3187d5a5
work_keys_str_mv	AT andrewdyurochko newmechanismbywhichhumancytomegalovirusmicrornasnegatetheproinflammatoryresponsetoinfection
_version_	1718427433126854656

New Mechanism by Which Human Cytomegalovirus MicroRNAs Negate the Proinflammatory Response to Infection

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