Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import

Maintenance of a mitochondrial NAD+ pool is critical for cellular life, yet the existence and identity of the transporter responsible for mitochondrial NAD+ uptake was unknown until recently. Here, the authors use genomic, genetic, and metabolomic approaches to demonstrate that SLC25A51 controls NAD...

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Autores principales:	Enrico Girardi, Gennaro Agrimi, Ulrich Goldmann, Giuseppe Fiume, Sabrina Lindinger, Vitaly Sedlyarov, Ismet Srndic, Bettina Gürtl, Benedikt Agerer, Felix Kartnig, Pasquale Scarcia, Maria Antonietta Di Noia, Eva Liñeiro, Manuele Rebsamen, Tabea Wiedmer, Andreas Bergthaler, Luigi Palmieri, Giulio Superti-Furga
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e8ac6a683e1a429f8d643e2061a12835
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spelling	oai:doaj.org-article:e8ac6a683e1a429f8d643e2061a128352021-12-02T15:37:10ZEpistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import10.1038/s41467-020-19871-x2041-1723https://doaj.org/article/e8ac6a683e1a429f8d643e2061a128352020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19871-xhttps://doaj.org/toc/2041-1723Maintenance of a mitochondrial NAD+ pool is critical for cellular life, yet the existence and identity of the transporter responsible for mitochondrial NAD+ uptake was unknown until recently. Here, the authors use genomic, genetic, and metabolomic approaches to demonstrate that SLC25A51 controls NAD+ mitochondrial levels and is the functional homolog of the yeast mitochondrial NAD+ transporter.Enrico GirardiGennaro AgrimiUlrich GoldmannGiuseppe FiumeSabrina LindingerVitaly SedlyarovIsmet SrndicBettina GürtlBenedikt AgererFelix KartnigPasquale ScarciaMaria Antonietta Di NoiaEva LiñeiroManuele RebsamenTabea WiedmerAndreas BergthalerLuigi PalmieriGiulio Superti-FurgaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Enrico Girardi Gennaro Agrimi Ulrich Goldmann Giuseppe Fiume Sabrina Lindinger Vitaly Sedlyarov Ismet Srndic Bettina Gürtl Benedikt Agerer Felix Kartnig Pasquale Scarcia Maria Antonietta Di Noia Eva Liñeiro Manuele Rebsamen Tabea Wiedmer Andreas Bergthaler Luigi Palmieri Giulio Superti-Furga Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import
description	Maintenance of a mitochondrial NAD+ pool is critical for cellular life, yet the existence and identity of the transporter responsible for mitochondrial NAD+ uptake was unknown until recently. Here, the authors use genomic, genetic, and metabolomic approaches to demonstrate that SLC25A51 controls NAD+ mitochondrial levels and is the functional homolog of the yeast mitochondrial NAD+ transporter.
format	article
author	Enrico Girardi Gennaro Agrimi Ulrich Goldmann Giuseppe Fiume Sabrina Lindinger Vitaly Sedlyarov Ismet Srndic Bettina Gürtl Benedikt Agerer Felix Kartnig Pasquale Scarcia Maria Antonietta Di Noia Eva Liñeiro Manuele Rebsamen Tabea Wiedmer Andreas Bergthaler Luigi Palmieri Giulio Superti-Furga
author_facet	Enrico Girardi Gennaro Agrimi Ulrich Goldmann Giuseppe Fiume Sabrina Lindinger Vitaly Sedlyarov Ismet Srndic Bettina Gürtl Benedikt Agerer Felix Kartnig Pasquale Scarcia Maria Antonietta Di Noia Eva Liñeiro Manuele Rebsamen Tabea Wiedmer Andreas Bergthaler Luigi Palmieri Giulio Superti-Furga
author_sort	Enrico Girardi
title	Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import
title_short	Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import
title_full	Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import
title_fullStr	Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import
title_full_unstemmed	Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import
title_sort	epistasis-driven identification of slc25a51 as a regulator of human mitochondrial nad import
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e8ac6a683e1a429f8d643e2061a12835
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Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import

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