Mode of conception in relation to nausea and vomiting of pregnancy: a nested matched cohort study in Sweden

Abstract Nausea and vomiting of pregnancy (NVP) is a common condition reported however inconclusively among pregnancies after assisted conception. The study objective was thus to explore whether NVP is associated to mode of conception or other in vitro fertilization (IVF)-related variables. This nes...

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Autores principales:	Farnaz Bazargani, S. I. Iliadis, E. Elenis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e8ac7ed3605e43fb8f1fa34836f03eb6
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spelling	oai:doaj.org-article:e8ac7ed3605e43fb8f1fa34836f03eb62021-12-02T14:53:42ZMode of conception in relation to nausea and vomiting of pregnancy: a nested matched cohort study in Sweden10.1038/s41598-021-88575-z2045-2322https://doaj.org/article/e8ac7ed3605e43fb8f1fa34836f03eb62021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88575-zhttps://doaj.org/toc/2045-2322Abstract Nausea and vomiting of pregnancy (NVP) is a common condition reported however inconclusively among pregnancies after assisted conception. The study objective was thus to explore whether NVP is associated to mode of conception or other in vitro fertilization (IVF)-related variables. This nested matched cohort study, originating from the BASIC-project, was conducted at the Uppsala University Hospital in Sweden between 2010 and 2016. IVF pregnancies (n = 210) and age and parity-matched women with spontaneous pregnancies (n = 420) comprised the study sample. The study outcome was self-reported NVP at gestational week 17. IVF treatment and pregnancy data were obtained after scrutinization of the medical records. NVP with or without medications was not associated with mode of conception (chi-square test, p = 0.889), even after adjusting for potential confounders. In a subgroup analysis among IVF pregnancies, NVP without medication was more frequently seen in the group who received cleavage stage embryos vs blastocysts (chi-square test, p = 0.019), exhibiting a marginally significant but strongly increased effect even after adjustment [crude RRR 3.82 (95% CI 1.23–11.92) and adjusted RRR 3.42 (95% CI 0.96–12.11)]. No difference in the rate of NVP with or without medication between women that underwent fresh and frozen/thawed embryo transfers as well as IVF or ICSI was observed. Conception through IVF is not associated with NVP. Transfer of a blastocyst may decrease the risk of developing NVP and further, large-scale prospective studies are required to validate this finding.Farnaz BazarganiS. I. IliadisE. ElenisNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Farnaz Bazargani S. I. Iliadis E. Elenis Mode of conception in relation to nausea and vomiting of pregnancy: a nested matched cohort study in Sweden
description	Abstract Nausea and vomiting of pregnancy (NVP) is a common condition reported however inconclusively among pregnancies after assisted conception. The study objective was thus to explore whether NVP is associated to mode of conception or other in vitro fertilization (IVF)-related variables. This nested matched cohort study, originating from the BASIC-project, was conducted at the Uppsala University Hospital in Sweden between 2010 and 2016. IVF pregnancies (n = 210) and age and parity-matched women with spontaneous pregnancies (n = 420) comprised the study sample. The study outcome was self-reported NVP at gestational week 17. IVF treatment and pregnancy data were obtained after scrutinization of the medical records. NVP with or without medications was not associated with mode of conception (chi-square test, p = 0.889), even after adjusting for potential confounders. In a subgroup analysis among IVF pregnancies, NVP without medication was more frequently seen in the group who received cleavage stage embryos vs blastocysts (chi-square test, p = 0.019), exhibiting a marginally significant but strongly increased effect even after adjustment [crude RRR 3.82 (95% CI 1.23–11.92) and adjusted RRR 3.42 (95% CI 0.96–12.11)]. No difference in the rate of NVP with or without medication between women that underwent fresh and frozen/thawed embryo transfers as well as IVF or ICSI was observed. Conception through IVF is not associated with NVP. Transfer of a blastocyst may decrease the risk of developing NVP and further, large-scale prospective studies are required to validate this finding.
format	article
author	Farnaz Bazargani S. I. Iliadis E. Elenis
author_facet	Farnaz Bazargani S. I. Iliadis E. Elenis
author_sort	Farnaz Bazargani
title	Mode of conception in relation to nausea and vomiting of pregnancy: a nested matched cohort study in Sweden
title_short	Mode of conception in relation to nausea and vomiting of pregnancy: a nested matched cohort study in Sweden
title_full	Mode of conception in relation to nausea and vomiting of pregnancy: a nested matched cohort study in Sweden
title_fullStr	Mode of conception in relation to nausea and vomiting of pregnancy: a nested matched cohort study in Sweden
title_full_unstemmed	Mode of conception in relation to nausea and vomiting of pregnancy: a nested matched cohort study in Sweden
title_sort	mode of conception in relation to nausea and vomiting of pregnancy: a nested matched cohort study in sweden
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e8ac7ed3605e43fb8f1fa34836f03eb6
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Mode of conception in relation to nausea and vomiting of pregnancy: a nested matched cohort study in Sweden

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